He is an acknowledged expert in drug discovery, particularly in the field of psychiatry, where he has led multiple projects into late stage preclinical development, many of which have progressed into clinical He has a degree and PhD in pharmacology from Queens' College, Cambridge and University College London He has published over 70 research articles, reviews and book chapters on drug discovery, which have been

He has held four Canada Research Chairs since 2001 and was previously a Heart and Stroke Foundation of He has also received both Junior (2001) and Senior (2005) investigator awards from the Pharmacological His research career has focused on the investigation of the regulation of G protein-coupled receptors

He has 20+ years of experience in in vitro and in vivo GPCR pharmacology and has published seminal papers

David has over 20+ years of experience working in a drug discovery environment mainly in a specialist During this period David has made a significant contribution to the understanding of agonist/ antagonist

From that point on, Paul was hooked and has since studied receptor function in human physiology, receptor molecular pharmacology in cells, and animal models, and as he puts it has now he’s "gone full circle

Habilitus, he was appointed at the University of Bonn as a Professor of Pharmaceutical Chemistry declining Peter has been chaired Full Professor of Pharmaceutical / Medicinal Chemistry at the Friedrich-Alexander Peter Gmeiner has been spokesman of the Research Training Group "Medicinal Chemistry of Selective GPCR

About Heidi Hamm "Heidi E. Hamm, Ph.D. is the Aileen M. The Department’s strengths lie in GPCR signal transduction and neuroscience, and she has expanded it Her laboratory has been involved in studying G protein coupled signal transduction for many years and has made key discoveries in G protein structure and mechanisms of activation by GPCRs and activation She has received numerous awards, including the Glaxo Cardiovascular Discovery Award, the Distinguished

modeling, pharmacology) to study G protein-coupled receptors (GPCRs) and purinergic signaling and now has He has published more than 800 scientific publications, with an H-index of 115. His numerous awards include: 2008 Sato Award; 2009 Medicinal Chemistry Hall of Fame (American Chemical

Milligan has published more than 550 peer-reviewed articles and his research has been cited more than

PARs have an N-terminal leader sequence that is clipped by exogenous proteases to reveal a new N-terminus Our current goals are to explore this mechanism in detail and to understand how it may happen for the Tall has been continuously funded by the NIH since receiving an early RO1 award at Rochester. He has continued funding at Michigan through the MIRA R35 program. Dr. Tall has presented his work at 59 invited seminars including national and international meetings and

Future Leader Fellow and runs a laboratory of 7 Ph.D. and Honours students at UNSW Sydney, where she has Smith’s team has made advances in the understanding of how an orphan GPCR exerts its effects both in

Sri Kosuri Sri is a biologist that has helped build technologies, labs, and companies in synthetic biology His lab has worked on building large-scale ways of empirically exploring questions in protein biochemistry Sri previously worked at the Wyss Institute and Harvard, where he built numerous technologies in gene

Professor Pfleger has developed extensive expertise in profiling receptor binding and function at the He also has globally-recognized expertise in bioluminescence resonance energy transfer (BRET) technology He is Head of Molecular Endocrinology and Pharmacology at the UWA Centre for Medical Research and Harry Kevin Pfleger on the web LinkedIn ResearchGate Pubmed Google Scholar University of Western Australia Harry

His work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular He has received substantial, long-term support from international and national competitive, charitable Professor Christopoulos has over 360 publications, including in leading international journals such as Nature,Science and Cell, and has delivered over 180 invited presentations. He has also been the recipient of multiple awards, including the John J.

nanoparticles can precisely initiate sustained endosomal signal transduction, while nanotechnology has Therefore, emerging evidence has revealed the interplay between GPCRs and nanoparticles, although investigations into their relationship have been inadequate. Nanotechnology has also been applied to construct synthetic nano-GPCRs or detect GPCRs, while endosomal

Since 2013, he has been elected Chair of the subcommittee for the Dopamine receptors of the International As of August 2022, he has over 270 publications in scientific journals (including Science, Nature, Cell

Its high expression on the surface of multiple myeloma cells has rendered it an attractive target for insufficient understanding regarding of the receptor's structure and antibody recognition mechanism has

Davide’s work has been published in prestigious scientific journals such as Nature, Cell, New England He has served on multiple panels and committees, including the ENDO Annual Meeting Steering Committee

Over the years, the meeting has grown into one of the most recognized international events in the field That reputation has led to broad participation from the Great Lakes region and beyond. The past few GPCR retreats have been held in : Niagara-on-the-lake (2022) Bromont, Québec (2019) Detroit

coupled receptors and receptor activity modifying proteins in vascular biology, the Caron laboratory has Caron has received numerous awards including a Burroughs Wellcome Fund Career Award in the Biomedical

His work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular He has received substantial, long-term support from international and national competitive, charitable Professor Christopoulos has over 360 publications, including in leading international journals such as Nature,Science and Cell, and has delivered over 180 invited presentations. He has also been the recipient of multiple awards, including the John J.

His work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular He has received substantial, long-term support from international and national competitive, charitable Professor Christopoulos has over 360 publications, including in leading international journals such as Nature,Science and Cell, and has delivered over 180 invited presentations. He has also been the recipient of multiple awards, including the John J.

However, it has become evident that heterotrimeric G-proteins can also be activated via GPCR-independent GIV/Girdin has emerged as a prototypical non-GPCR activator of G proteins that promotes cancer metastasis

this work, a structural investigation on the two position of the [1,2,4]triazolo[1,5-c]pyrimidines has Compound 20 has been tested on both A3 adenosine receptor positive cancer cell lines (CHO-A3AR transfected

Ribeiro has supervised eleven M.Sc. and six Ph.D. students, as well as five post-doctorate fellows. Ribeiro has 86 per reviewed scientific papers published in highly respected scientific journals, including She was able to have several grants approved in Brazil and abroad, which have granted her research group

Class B1 GPCR peptides such, as growth hormone-releasing hormone (GHRH), have been proposed to bind in The GHRHR has recently been highlighted as a promising drug target toward several types of cancer and has been shown to be overexpressed in prostate, breast, pancreatic, and ovarian cancer. Indeed, peptide GHRHR antagonists have displayed promising results in many cancer models. However, no nonpeptide GHRHR-targeting compounds have yet been identified.

The functional relevance of C5aR2 appears to be context-dependent compared to the C5aR1, which has received The current study has attempted to close the gap by generating highly refined model structures of C5aR2

His training has provided a strong foundation and appreciation for the applications of pharmacology, The structural work on the GPCR-G protein complexes have also revealed some unprecedented conformational More recently we have have been heavily engaged in studies to address the functional role of these dramatic The Sunahara lab has also been developing protein-based therapeutics using structure-guided design and computational approaches the Sunahara lab and collaborators developed a thermostable form of the enzyme that has