treatment of obesity and Type 2 Diabetes (T2D) by exploring metabolically important signaling pathways in immune knock-out and transgenic mouse models, along with different cell culture systems, to understand the role of immune

He currently is focusing on the development of nanobody-based immuno tracers as part of the IMI/EFPIA project entitled "Immune Image".

The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy .

Rottapel’s research interests lies in the elucidation of signal transduction pathways in cancer, immune The Rottapel lab has shown that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell

Stimulation of GAL2 receptor may modulate immune surveillance and inhibits PDAC via cell cycle inhibition Pathways linked to these tumor suppressor proteins may enhance immune surveillance, prevent carcinogenesis

Together, these highlight that the CXCL16-CXCR6 axis is pivotal in host immunity. ITGAE, CXCL16, and CXCR6 in chickens may have altered CD8 TRM cell abundance, with implications for immunity

We studied injury-induced immune dysfunction seeking novel means to reverse such predisposition. Conclusions: Tissue injury-derived DAMPs suppress antimicrobial immunity via canonical GRK2 activation

In this issue of Immunity, Gour et al. demonstrate that the GPCR Mrgpra1 and the neuropeptide NPFF, molecules

Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 3. receptors impact cardiac structure and function, and has evolved to encompass their roles in regulating immune

postdoctoral work that led to Nick's interest in peptide messengers regulating appetite, metabolism, and the immune

activation/function of CXCR4-ACKR3 (CXCR7) receptors of the CXCL12 chemokine, key effectors of the immune

platelet aggregation and adhesion to cancer cells, promote tumor angiogenesis, and affect the tumor immune

receptor-ligand interactions are highly relevant for its different physiological effects, e. g. the migration of immune

sink for CCL19 to coordinate collective leukocyte migration Published date September 1, 2023 Abstract "Immune

monocytes use CCR5 to follow CCL5-secreting migratory cDCs into the LN, where they regulate DC-mediated immunity

surface levels of the GPCRs C5aR1 and CXCR4 in neutrophils, and suppresses neutrophil-mediated innate immunity

pathogenesis of Long-COVID is currently under heavy scrutiny and existing data on the role of auto-immune

is a classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that tailors immune

druggable extracellular proteins, this axis plays essential roles in fibrosis, inflammation response and immune

CCRs were significantly induced in spleen of largemouth bass, indicating their important roles in the immune

November 1, 2022 Abstract The rheumatoid arthritis (RA) inflammatory process occurs in the joints where immune

Disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by disrupted immune

In this setting, OGR1 KO mice displayed an increased activation of the immune system and a higher production

Hence, this study was conducted to identify the interaction sites and binding affinity between several immune-related

remodeling regulation of actin cytoskeleton organization by the kinase effectors of Rho GTPases" and "Immune

These findings provide a better understanding of the role of IL-8 in PEDV-induced immune responses, which

Earlier study demonstrated that pharmacological activation of GPR110 in both central and peripheral immune

Here, we use validated and certified immune assays presenting native receptors as binding targets.