created or plan on creating to showcase your company products and help your customers use the technology effectively Listings Get your products in front of your GPCR customers, answer any questions they may have and get direct

Neutralization and knockdown of prosaposin or blocking GRP37 abrogates the pro-resolution effects of

In cancer, chemokines play paradoxical roles in both the directed emigration of metastatic, receptor-expressing In the age of precision oncology strategies to effectively harness the power of immunotherapy requires

small-molecule CXCR2 antagonists have entered clinical trials, showing favorable safety and therapeutic effects

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Our mechanistic studies reveal that the therapeutic effects of CB2 are mediated through activation of

His clinical expertise is in monogenic autoinflammatory disorders and the autoimmune adverse effect resulting

my lab will strive to develop novel GPCR pharmacotherapies that improve efficacy and minimize side effects

hydroxytryptamine, and chemokine receptors, are the targets of multiple drugs displaying anti-growth effects

This effect is reduced by pertussis toxin (PTX) and GUE1654, a biased antagonist for the Gβγ pathway Subsequent signaling analysis reveals a strict requirement of phospholipase C β3 (PLCβ3) and its downstream effector structures, we identified the PI3K-regulated guanine nucleotide exchange factor (GEF) FARP1 as a GPCR effector

Abstract "Colorectal cancer (CRC) remains a major global cause of cancer-related mortality, lacking effective

functions of kinin receptors and KLKs, this review highlights their roles, even considering the SARS-CoV-2 effects

Unraveling the complexities of extracellular ATP (e-ATP) and ADO effects on the TME poses challenges

27599" About Monserrat Avila Zozaya "My doctoral research was focused on investigating the cellular effects However, it is unclear which domains of ADGRG6 are N-glycosylated and how this might affect the overall

analysis of drug action and is known for applying binding and signaling kinetics to the development of effective

Invasive procedures alone are not effective at completely removing such tumors. pathways included "Cytoskeleton remodeling regulation of actin cytoskeleton organization by the kinase effectors

The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs

Functional enrichment analysis revealed the promising therapeutic effects of these targets on GPCRs-related

landmarks into a postdoc, such as applying for funding opportunities, and getting diverse feedback to effectively Both agreed on the importance of adaptability, as unexpected situations like the Covid-19 pandemic can affect

GBM is the most aggressive primary brain neoplasm that affects adults, with a median survival of 12-15 These flaps could theoretically enable partial decryption of the Stachel through lateral movement and affect To investigate whether flexibility of GAIN flaps affects aGPCR function under native conditions, we strategically This regimen has long lasting side-effects, including neuroendocrine and cognitive problems, and ~ 30%

and Immunology Respiratory infections predominate after day 100 following B-cell maturation antigen-directed 26, 2023 Abstract "Infections are an important complication after B-cell maturation antigen (BCMA)-directed We evaluated infections in 99 adults who received a first BCMA-directed CAR T-cell therapy (commercial Thirty-seven patients (37%) experienced 64 infectious events over the first year after BCMA-directed

compounds in Jinqiancao granules that have synergistic mechanisms, contributing to anti-inflammatory effects

In an in vivo study, the effects of RGS6 knockout were studied in a mouse model of ALI induced by lipopolysaccharide

Using complimentary cellular and biochemical approaches, proteins were tested for effects on GPCR-G α

We also touched on how COVID-19 affected her Ph.D. work.

in baseline. 24hr water deprivation experiment showed that GPR56CD-KO mice can concentrate urine as effectively We will present the effects of BAI3 re-expression on WNT-MB cells oncogenic properties and signaling. This study aimed to understand the effects of GPR110 on mouse behaviors in relation to neurodevelopmental

During that time, I investigated the effect of lung cancer-related mutations in the GAIN domain of the

the need for a disease-specific approach, considering the clinical context and dialing in the desired effect