research laboratory of around 15 staff supported by basic research grants investigating aspects of disease biology and the action of drugs in the context of disease.

and pharmacology aiming to understand the role of WNT/Frizzled signaling in biology, physiology, and disease find, create and optimize Frizzled-targeting small molecule drugs to improve future therapies of human disease

, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular disease They highlighted the importance of fine-tuning the approach to suit different diseases and interdisciplinary The discussion also emphasized the need for a disease-specific approach, considering the clinical context Arthur and Yamina discussed the potential of autoantibodies and allosteric modulation in the context of disease

the investigation of the regulation of G protein-coupled receptors signaling mechanisms in health and disease investigating the role of metabotropic glutamate receptor signaling in Huntington’s and Alzheimer’s disease

laboratory has gained valuable insights into the genetic basis and pathophysiology of lymphatic vascular disease , preeclampsia and sex-dependent cardiovascular disease.

elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors exhibited decreased disease-specific survival (DSS) and disease-free survival (DFS) compared to those with low RGS16 expression.

More Friday, November 3rd / 9:20 AM Cannabinoid compounds to augment L-DOPA treatment in Parkinson's Disease and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Friday, November 3rd / 11:05 AM Biased agonism at the GLP-1 receptor: from structure to animal models of disease Columbia Read More Friday, November 3rd / 2:10 PM Genetic Deletion of Atypical VGLUT3 Rescues Huntington’s Disease

in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases She is currently working to understand the signaling and degradation of GPCRs in disease states to help

My group studies the spatiotemporal dynamics of atypical inflammation and the control of disease progression

and clinical pharmacology as scientist or PI in neonatal lupus, Cardiomyopathy, hypertension, chagas disease

tiny antenna-shaped structure at the cell surface with critical links to development, physiology, and disease

She is currently working to understand the signaling and degradation of GPCRs in disease states to help

in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases

studies to address the functional role of these dramatic conformational changes and the relationship to disease continues to engineer the enzyme to optimize its potential as a treatment for cocaine abuse, a debilitating disease

physiological and pharmacological principles that underlie the workings of adhesion GPCRs in health and disease

development of new therapeutic interventions for the alleviation of L-DOPA-induced dyskinesia in Parkinson’s Disease

neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's disease

of growth factors and their signaling mechanisms in development, adult tissue homeostasis, and human diseases

in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases

and pharmacology can provide new opportunities to improve our understanding of human physiology and disease

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Diseases he aims to apply this knowledge to develop novel chemical treatments for neuronal and cardiovascular diseases

neurotransmitters and how they might underlie brain and behavior disorders such as schizophrenia, Parkinson's disease

, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular disease Lastly, they discussed the progress of new drugs targeting specific receptors for various diseases, with

Our laboratory is working to help patients by developing genetically-modified mice that have disease-causing

second area of interest has been the elucidation of the molecular basis for a rare autosomal human disease

small molecules can selectively disable noncanonical mechanisms of G-protein activation dysregulated in disease

Despite advances in the treatment, many patients experience disease relapse or become refractory to treatment

were shown to be very effective to rescue the cell death observed in a mouse model of Huntington’s disease