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90 items found for "Isabella C Russell"
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
hormone receptor (TSHR) has been shown to regulate distinct cellular processes, including phospholipase C B., & Diniz, C. (2021). B., Gonçalves, J., & Diniz, C. (2019). C., Götz, K., Sungkaworn, T., Lohse, M. J., & Calebiro, D. (2016).
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The head mesodermal cell couples FMRFamide neuropeptide signaling with rhythmic muscle contraction in C. Board of Directors Crinetics Pharmaceuticals Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)
- Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans
signaling molecule that regulates the regenerative pathway in the nervous system.SIGNIFICANCE STATEMENTIn C. C. elegans secretes a family of small-molecule pheromones called ascarosides, which serve various functions
- Chemerin Forms: Their Generation and Activity
from the coagulation and fibrinolytic cascades, as well as from inflammatory reactions, process the C-terminus
- Class B1 GPCR Dimerization: Unveiling Its Role in Receptor Function and Signaling
While GPCRs can exist as monomers, some types, like class C GPCRs, are obligate dimers, either as homodimers Graaf, C., et al., Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March
- GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
we show that GRKs generate distinct phosphorylation barcodes in intracellular loop 2 (ICL2) and the C
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Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class C G Protein-Coupled Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and
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consequences of spatial, temporal and ligand bias of G protein-coupled receptors Inverse Regulation of C-C
- β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
Moreover, we assess β-arrestin conformational changes that are induced specifically by proximal and distal C-terminal
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
activated, ERKs translocate to the nucleus, phosphorylating various transcription factors, including ETS, c-Jun Lu, N., & Malemud, C. J. (2019).
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
divided into six classes based on amino acid sequence similarities, but only four of the classes (A, B, C,
- Discover the Hottest GPCR News of the Week: Oct 7-13, 2024!
Launched Crinetics Pharmaceuticals Announces October 2024 Inducement Grants Under Nasdaq Listing Rule 5635(c) weight gain in female rats Neuropeptide and serotonin co-transmission sets the activity pattern in the C.
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
., & Humblet, C. (1998). G-protein coupled receptors: models, mutagenesis, and drug design. C., Sykes, D. A., Viray, A. E., Vitale, R. M., Tomašević, N., ... & Carreira, E. M. (2024).
- Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of...
Although it has been established that the palmitoylation of the C-terminal Go protein is essential for
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Receptor Expression Pharmacokinetics and Pharmacodynamics of Burixafor Hydrobromide (GPC-100), a Novel C-X-C
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
CCR2 canonical signaling requires the activation of Gαiβγ, followed by phosphorylation of the receptor C constitutively interacts with β-arrestin2, and constitutively internalizes in a β-arrestin2–dependent manner (C. Volpe et al. 2012); it dampens the inflammatory response when needed (C. A. H.
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
October 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
with the 2 cases we previously reported as follows: (a) elderly (74-87 years at diagnosis), (b) male, (c)
- Glyco-sulfo hotspots in the chemokine receptor system
In silico analyses done in this study with the NetOGlyc 4.0 prediction algorithm (Steentoft C et al. phosphosulfate (PAPS) donor to the hydroxyl group of a tyrosine residue of the protein chain (Seibert C glycosaminoglycans which have an established role in chemokine gradients and oligomerization (Deshauer C
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
generating highly refined model structures of C5aR2, respectively in free (inactive), complexed to C-terminal
- Delineation of GPR15 receptor-mediated Gα protein signaling profile in recombinant mammalian cell
G protein-coupled receptor (GPCR), which is activated by an endogenous peptide GPR15L(25-81) and a C-terminal
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
November 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed
- Transformative GPCR Insights: Unleash New Horizons in Science | Sep 9 - 15, 2024
C. Burger , Arthur Christopoulos , David M. Crinetics Pharmaceuticals Announces September 2024 Inducement Grants Under Nasdaq Listing Rule 5635(c)
- Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890
binding to βγ and decreased binding to regulator RGS2, and effectors p63RhoGEF-DH/PH and phospholipase C-β
- PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
Point mutations are in the C-tail of PAR4 PH-binding domain; F347 L and D349A, but not E346A, abrogate
- Unlock the Future of GPCR Science: Breakthroughs and Courses Await | Sep 2 - Sep 8, 2024
(trans) function of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C. (trans) function of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C.
- Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs)...
some important clinical parameters such as alpha-fetoprotein and tumor grade in the HCC patients; (c)
- Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water ...
water flea Diaphanosoma celebensis genome, which were classified into five distinct classes (A, B, C,