July 21st marks our next Dr. CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA.

Mark your calendars for these important events: September 22: Save the date for the Dr. You can submit your poster abstracts using this form and short talks will be selected from abstracts. reticulum-mitochondrial coupling in diabetic retinopathy GPCR Binders, Drugs, and more The Leu/Val6.51 Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ9-Tetrahydrocannabinol GPCRs Drug Targets: Allosteric Function and Biased Signaling" at the DOT NEW October 3, 2023 | FREE Seminar: Changing

Mark your calendars for September and October 2024! We are excited to announce that Dr. GPCR Matchmaking Meet Mark Schmeizl, our Chief Matchmaker. Whether you’re hiring top talent or seeking a new career opportunity, Mark’s expertise ensures successful Mark discussed this position with Beth Fleck, Director of In Vitro Pharmacology at Crinetics Pharmaceuticals Mark your calendar for the GPCRs as Therapeutic Targets symposium on October 11th, 2024.

Mark your calendar for September and October 2024. Dr. GPCR Matchmaking Mark Schmeizl, our Chief Matchmaker, can help you find your perfect match if you want Mark has experience connecting candidates with employers and will work with you to understand your needs Contact Mark today to get started. Dr. Mark your calendar for October 23 - 25, 2024, as we kick off the 11th Adhesion GPCR Workshop in Mexico

Our Chief Matchmaker, Mark Schmeizl, had a great conversation about this position with Beth Fleck, Director Also, if you are looking to hire or be hired, Mark Schmeizl can help you find your perfect match. Mark has experience connecting candidates with employers and will work with you to understand your needs Contact Mark today to get started. and Signaling Beneath the surface: endosomal GPCR signaling The M3 muscarinic acetylcholine receptor can

GPCR News video edition, we chatted with Dr. Oliver Hartley. GPCR Activation and Signaling Targeting biased signaling by PAR1: Function and molecular mechanism of Structural and Molecular Insights into GPCR Function Physiological changes in bilayer thickness induced Ultrafast structural changes direct the first molecular events of vision. Sosei Heptares Confirms Changes to its Board and Executive Management Team at Annual Shareholders’ Meeting

Mark your calendar for October 10th and 16th.

GPCR University Today marks the final day of the Dr. GPCR Matchmaking Read Mark's job spotlight article for a Principal Scientist in In Vitro Pharmacology Mark recently discussed this exciting opportunity with Beth Fleck, Director of In Vitro Pharmacology

extracellular loops and transmembrane domains of the receptor (CRS2), which will trigger conformational changes This effect could be driven by a specific carrier or it can potentially be related with the increase GSnP-6 displays nanomolar affinity and promising potential for blocking PSGL-1/P-selectin interaction (Wong Moreover, sulfated mCCR2 peptides can outcompete available chemokines, decreasing retinal degradation in mice (Jung SA et al. 2021).

GPCR Symposia Mark your calendars! GPCR University Today marks the conclusion of the Dr.GPCR University course, ‘Applying Pharmacology to You can still sign up for our waitlist. We will be offering this live course again later this year. our events, and get a complimentary Premium Membership with only 4 hours/monthly commitment on your part Whole Brain Mapping of Orexin Receptor mRNA Expression Visualized by Branched In Situ Hybridization Chain

We are closely monitoring any regulation changes from both Boston and Massachusetts with regard to in-person If there are any changes made that will impact our ability to hold the event in-person, we will notify Please refer to our Safe Meeting guidelines for information about how you can participate in the event Don't miss the chance to present your innovative research at this year's conference.

GPCR Ecosystem group, where you can find Dr. GPCR Ecosystem perks, including our forums, private groups, and all Ecosystem members Extended early GPCR Symposia With a premium membership, you can watch on-demand the Dr. bioinformatics analysis Unveiling the therapeutic prospects of EGFR inhibition in rotenone-mediated parkinsonism Domain Therapeutics to Present Latest Data on DT-9045, a First-in-class Negative Allosteric Modulator of PAR2

Mark your calendars! The Dr. GPCR Podcast is back this week with a brand new episode. Our guest is none other than Dr. Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.

Mark your calendars and get your ticket today! The Dr. GPCR Virtual Cafe is back! Our first guest speaker is none other than Dr. Ben Myers!

Take the chance to contribute to this exciting event! For Dr. FSLLRY-NH2, a protease-activated receptor 2 (PAR2) antagonist, activates mas-related G protein-coupled

Be sure to mark your calendars and secure your spot for this extraordinary learning opportunity! Take advantage of the chance to showcase your creativity by participating in the Logo Contest . Submit your design by August 15, 2024, and stand a chance to have your creation represent this prestigious

severe pain by activating the μ-opioid receptor (MOR), whereas naloxone, with only slight structural changes The endogenous peptide ligand endomorphin-1 (EM-1) underwent almost no significant conformational changes Reducing the side chain size of I322 (MORI322A) transformed naloxone from an inhibitor directly into

excellent study on GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery 🚨 LAST CHANCE This is your chance to get the whole experience of our comprehensive pharmacology courses for less! No worries – you can sign up for a 5-day FREE trial! Mark your calendars and make sure to enroll before the deadline!

Find speaker details on the Live Talks page and mark your calendar HERE. Sosei Heptares to Host R&D Day Highlighting its Innovative R&D and Late-Stage Development Progress Parker

Don't miss out, and mark your calendar! Dr. from March 4th to 10th, 2024 GPCR Activation and Signaling Glu1022.53-Mediated Early Conformational Changes

into this week’s news, we’d like to draw your attention to some of our events and resources: Please mark Autocrine Proteinase-Activated Receptor (PAR) signaling in PC3 prostate cancer cells. Insights into GPCR Function Structural insights into ligand recognition and activation of the medium-chain

payment of $100 million with the potential of $5.2 billion in total milestones plus tiered royalties PARIS

endocytosis in HEK293 and Huh-7-Lunet cells after activation by glucagon within 5 min and transit via EEA1-marked

CKRs can be classified into typical CKRs, atypical CKRs (ACKRs) which lack G-protein signaling, and viral The chemokine system exhibits great versatility, with more than 50 chemokines interacting with over 20 interaction follows a common pattern which is generally described by the classic “two-site” model (Crump, Gong et al. 2017, Isaikina, Tsai et al. 2021, Zhang, Chen et al. 2021). non-canonical toggle switch results in the separation of TM3 and TM6 following chemokine binding to the upper part

It’s time to mark your calendars and save the dates—let’s make some stellar memories together! Congrats to: Ya-Tzu Li , our notable contributor, for her superb undergrad paper along with Hao-Jen Hsu , Chun-Chun Chang , et al.   Drugs like Ozempic will change the world GPCR Events, Meetings, and Webinars November 5 - 7, 2024 | 16th

GPCR Symposia Mark your calendars! Mark your calendar; we’re planning a workshop for May 2024 with Dr. Sam Hoare as our instructor.

Mark your calendars for the following events: September 22- TOMORROW: Attend this Friday's Dr. Registrations are closed but you can send an email to gpcrretreat@uottawa.ca to be added to the waitlist Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic cells in mice and humans Mark cardiometabolic disease GPCRs in Neuroscience Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson's