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43 items found for "Junwei Tang"
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
Nevertheless, the GloSensor™ cAMP assay can be applied to analyze signaling by a wide range of GPCRs
- A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr
Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled
- The development of modulators for lysophosphatidic acid receptors: A comprehensive review
Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
GPCRs are present in a range of conformations, and the binding of a ligand, as well as interactions with desensitization), the same drug acting on the same receptor in the same cellular context can produce a range
- GPCRS: AN ODYSSEY FROM STRUCTURE, SIGNALING AND REGULATION TO THERAPEUTICS
Coupled with their ability to respond to a highly diverse range of chemical stimuli, they represent the
- Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans
Chemical communication controls a wide range of behaviors via conserved signaling networks.
- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
Consequently, the dynamic range for IL-6 detection as an assay for β-alanine-mediated activation of MRGPRD
- Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the ...
Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the range of
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
could unveil new dimensions of GPCR functionality and offer innovative approaches to treating a wide range
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
However, the receptors that these medicines target have been described as the ‘low-hanging’ fruit, and There are approximately 800 human GPCRs in the superfamily, controlling a broad range of physiological Orion’s receptor antagonist analogs have demonstrated powerful efficacies across a range of animal models
- Therapeutic validation of an orphan G protein‐coupled receptor
Regarding the first question, GPR84 overexpression in immune cells in a range of pro‐inflammatory disorders indole‐3‐carbinol, which is present at high levels in some vegetables including broccoli and kale (Wang
- From DNA day to GPCR genomics
The completion of the Human Genome Project revealed that GPCR genes in the human genome range from approximately
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
“ A substitution of one amino acid by another in a protein can have effects ranging from negligible to
- Chemokine receptor-targeted drug discovery: progress and challenges
The chemokine receptor system is implicated in a wide range of inflammatory, autoimmune and infectious binding, as well as G-protein coupling or interaction with other signaling molecules (Sohy et al. 2009; Wang protein-protein interactions which are difficult to modulate using small molecules (Sohy et al. 2009; Wang
- Structural landscape of the Chemokine Receptor system
([6P4]CCL5), a chemokine antagonist ([5P7]CCL5), and a small-molecule inverse agonist (maraviroc) (Tan activation will pave the way for significant advancements in the development of therapeutics for a wide range