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81 items found for "Kallikrein-related peptidases"
- Ep 38 with Dr. Alexander S. Hauser
worked on novel analytical methods to identify human signaling systems and thereby discovered endogenous peptides
- Session IX / Technology capsule: Light on aGPCR signaling and function | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
This approach contrasts with other antigen forms like peptides or DNA, which face limitations in structural
- Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity
The production of CXCL10(1-73) was optimized through Fmoc-based solid phase peptide synthesis (SPPS) Angiogenesis , CXCL10 , Chemokine , Lymphocytes , Posttranslational modifications , Proteolysis , Solid phase peptide
- Ep 85 with Nicholas Holliday
It was these studies and subsequent postdoctoral work that led to Nick's interest in peptide messengers
- Ep 20 with Dr. Jennifer Pluznick
renal and cardiovascular function, and identifying renal/cardiovascular olfactory receptor ligands, and relating
- Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
Methods: Congruously regulated G protein-coupled receptor (GPCR)-related genes and differentially expressed genes (61 congruously upregulated and 49 congruously downregulated genes) were identified among GPCR-related
- Session I | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
the characterization of a non-cleavable point mutant knock-in mouse, H381S Frank Kwarcinski Tethered Peptide Tethered Agonist (TA)-mediated model of aGPCR activation, the ECR acts as a protective cap for the TA peptide The TA peptide remains at its original position and is not involved in signaling. Frank Kwarcinski on the web LinkedIn Tethered Peptide Activation Mechanism of Adhesion GPCRs Peng Xiao
- Ep 103 with Dr Kathleen Caron
Oliver Smithies at UNC-CH, where she was the first to discover the essential role of adrenomedullin peptide
- Ep 126 with Dr. Françoise Bachelerie
Françoise Bachelerie " FB leads a team at Paris-Saclay University with expertise in immunology and virology related
- Ep 56 with Dr. Adriano Marchese
knowledge to reveal the spatial and temporal requirements for GPCR activation of signaling pathways related
- From odor to oncology: non-canonical odorant receptors in cancer
dysregulation of non-canonical odorant receptors such as trace amine-associated receptors (TAARs), formyl peptide
- Affiliate Policy | Dr. GPCR Ecosystem
GPCR Ecosystem; - Sites with content related to sexual, religious, political, or other sensitive matters disclaims all liability for your site, social media, and other content and any of your users’ claims relating GPCR harmless from and against all claims relating to your site. 4. Modification Dr.
- GPCR Retreat 2023 - Part I
With respect to GPCRs, I'm particularly interested in peptide/small protein receptors and the mechanisms Oliver Smithies at UNC-CH, where she was the first to discover the essential role of adrenomedullin peptide
- Noval insights and therapeutic strategies for tumor-induced kidney pathologies
insights could contribute to the advancement of diagnostic and therapeutic strategies for treating tumor-related
- Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
Intermediate-state-trapped mutants will also provide useful information in relation to receptor-G protein
- "Have a nice weekend, and I'll see you tomorrow!": RAMP-interacting GPCR Pathways
Oliver Smithies at UNC-CH, where she was the first to discover the essential role of adrenomedullin peptide
- NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
signaling Published date September 1, 2023 Abstract "Neuropeptide FF (NPFF) belongs to the RFamide peptide
- High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro
relative and absolute quantification (iTRAQ) analysis, and we found that GPR50 promoted HCC was closely related
- Ep 87 with Dr. Bianca Plouffe
used Bioluminescence Resonance Energy Transfer (BRET)-based technology to tackle important questions related
- A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages
that A2aR is specifically expressed on tumor cells from lung adenocarcinoma (LUAD) patients, closely related
- Interaction with the cell adhesion molecule NEGR1 affects mGluR5 cell signalling
death observed in a mouse model of Huntington’s disease (HD), decreasing synaptic loss and enhancing HD related
- Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes
recruits GPCR kinases (GRKs) and β-arrestins and promiscuously responds to CXCL12, CXCL12 variants, other peptides
- Gallein, G protein βγ subunits inhibitor, suppresses the TGF-α-induced migration of hepatocellular carcinoma cells via inhibition of the c-Jun N-terminal kinase
In contrast, fluorescein, a gallein-related compound that has no effect on Gβγ subunits, failed to affect
- GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced lymphomagenesis
Our multi-omics analysis of NKTCL revealed that EBV gene pattern correlated with immune-related oncogenic
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
Published date June 21, 2024 Abstract "Colorectal cancer (CRC) remains a major global cause of cancer-related
- Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans
The inhibition in JNK MAPK and ERK MAPKs signals in CPPDQ exposed nematodes was further related to alteration
- From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction
There are multiple examples of the induction of CCN proteins by LPA, and by the related lipid mediator
- Ep 151 with Dr GPCR Board
She has made numerous important discoveries related to the mechanisms that control PAR1 signaling and closely related family members and published extensively on this topic.
