K ´ onigstorfer, M. Mozhayeva, Y. Sara, T.C. Südhof, and ¨ E.T. Kavalali. 2001.

Anson, M., et al., Incidence of new onset type 2 diabetes in adults living with obesity treated with

Magdalena M Scharf, Antonella Di Pizio, Ines Liebscher, Hannes Schihada, and Gunnar Schulte et al. on

Nayara Braga Emidio, Ross Cheloha, Laura M Wingler, et al. for their work on Nanobody-Mediated Dualsteric

Maziarz, M., et al., Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor

insights into G protein coupling specificity at a class A GPCR Jianjun Cao, Arthur Christopoulos, Patrick M.

a GPCR Paper with his team: Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR China M

Burger , Arthur Christopoulos , David M.

genito-urinary system, the activation of ORs was shown to influence the motility of spermatozoa (Spehr M.

More specifically, this review covers assays to monitor the canonical G protein signaling pathway (e.g recruitment/activation, inositol phosphate accumulation, or Ca2+ mobilization), assays to monitor non-canonical

GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024) GPCR Jobs NEW Postdoctoral Fellow, Caron

Senior Scientist- Membrane Technologies NEW Computational Protein Design (GPCR) Postdoctoral Fellow, Caron

December 2021 " Dame Carol Robinson DBE, FRS, FRSC, FMedSci, Oxford University’s first female Professor

highlighted a new hydrophobic conserved motif composed of phenylalanine (F)/leucine (L) and methionine (M)

October 2022 "G protein-coupled receptors (GPCRs) are important drug targets characterized by a canonical

Surgery Senior Scientist- Membrane Technologies Computational Protein Design (GPCR) Postdoctoral Fellow, Caron

October 2022 "The canonical model for G protein-coupled receptors (GPCRs) activation assumes that stimulation

Here, we determine that GRKs phosphorylate a non-canonical substrate, anterior pharynx-defective 1A (

various cellular processes such as cell proliferation, migration, apoptosis, and transcription via canonical

various cellular processes such as cell proliferation, migration, apoptosis, and transcription via canonical

Aaron Sato , Chief Scientific Officer at Twist Bioscience , elaborates.

Shampo, M. A. & Kyle, R. A. Sir Bernard Katz--winner of Nobel Prize in physiology or medicine. Ekaterini Tiligada, C., Tiligada, E. & Ennis, M.

7TM-independent functions of Latrophilins are essential for neuronal physiology, possibly complementing canonical

All CKRs studied show the canonical active conformation, except CX3CR1 which displays a significantly As a result of the unique active conformation, the residues in the microswitch network show non-canonical The Non-canonical Toggle Switch 6.48 - CCR6 as a model CKR The structure of CCR6 bound to CCL20 reveals the "toggle switch" position 6.48 and the disruption of a hydrogen-bond network surrounding this non-canonical

highly-conserved GPCR-autoproteolysis-inducing (GAIN) domain, the latter of which is located immediately before a canonical

Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives Non-canonical

effectors along the Gαq/Phospholipase C (PLC) pathway, which results in an IkB kinases (IKK)-mediated canonical

non-cognate G proteins can enhance the coupling efficiency of cognate G proteins to GPCRs, thereby amplifying canonical