Bryan Roth, Peter Gmeiner, and Thomas P. Sakmar this week. For Dr. Subthreshold GPCR Signals Combined by the G-Proteins Gαq and Gαs Activate the Caenorhabditis elegans Egg-Laying

bioinformatics tools offer the potential to explore larger portions of the β-arrestin interactome (Crépieux, P. with overlapping sites may experience mutually exclusive binding due to steric hindrance (Crépieux, P.

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and TM7 on the other hand, form possible dimerization interfaces (Ploier, B. et al. 2016; Dijkman, P.

Thomas P. Sakmar, Debbie L. Hay, Lukas Grätz, and more.

challenge in the Dahl SS rat GPCRs in Neuroscience Neurokinin-2 receptor negatively modulates substance P

receptors, data mapper, structure similarity search and models of physiological ligand complexes Luis P

-P., Macdonald, C. B., Mehrotra, E., Patrick Rockefeller Grimes, Zahm, A. M., Trinidad, D.

They also showed higher protein levels of phospho-glycogen synthase kinase-3β (p-GSK3β), as well as total

Toxicol. 52, 179–197. https://doi.org/10. 1146/annurev.pharmtox.010909.105800 Tsao, P.

The right environment, paired with a supportive supervisor, laid the foundation for a fulfilling and

Structural explanation of the receptor binding mechanism of a highly potent antagonist analog Isaikina, P.