Search Results
64 items found for "Lina Yang"
- CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases
Abstract " The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range
- Chemoattractant receptor signaling in humoral immunity
sites on the receptor C termini, which dictates functional outcomes of β-arrestin-mediated signaling, ranging
- High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases
Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein
- Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
provide useful information in relation to receptor-G protein signal transduction. " Authors Xudong Wang
- GprC of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells for nematode hunting
Authors Xiaodi Hu, David S Hoffmann, Mai Wang, Lars Schuhmacher, Maria C Stroe, Birgit Schreckenberger
- GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment
Migration of GPR4 overexpressing SK-Mel-28 cells was enhanced in a range of pH 6.5 - pH 7.5 as compared Authors Judith Anthea Stolwijk , Susanne Wallner , Judith Heider , Bernadett Kurz , Lisa Pütz , Stefanie Michaelis , Barbara Goricnik , Julia Erl , Linda Frank , Mark Berneburg , Frank Haubner , Joachim Wegener
- High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro
analyzed in HCC patients (gene expression omnibus database (GEO) (GSE45436)) and detected in HCC cell line and the results showed that GPR50 was significantly up-regulated in HCC patients and CBRH-7919 cell line Gpr50 cDNA was transfected into HCC cell line CBRH-7919, and we found that Gpr50 promoted the proliferation Authors Weiming Zhao , Lingling Xi , Guoying Yu , Gaiping Wang , Cuifang Chang Source Contribute to the
- CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration
We further show that these self-generated gradients can sustain the long-range guidance of DCs, adapt
- miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population
Authors Jijun Chen , Liang Wang , Danhua Ma , He Zhang , Jiayan Fan , Hongyan Gao , Xinyu Xia , Wei Wu
- A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages
Authors Ying Bai , Xin Zhang , Jiawei Zhou , Jianqiang Guo , Yafeng Liu , Chao Liang , Wenyang Wang ,
- Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
A 12-point immunoreactive scoring (IRS) range was used for interpretation of the staining results.
- Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors
targets such as the LPA and mGlu receptor families, but also discovered novel GPCRs which had not been linked Authors Bongers B J , Gorostiola González M , Wang X , van Vlijmen HWT , Jespers W , Gutiérrez-de-Terán
- Principles of Pharmacology in Drug Discovery I
of how pharmacology can greatly extend the ability to predict a candidate's therapeutic value in a range
- GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological processes ranging
- NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
Authors Ze Wu , Qiongqiong Jia , Boqun Liu , Lanlan Fang , Peter C K Leung , Jung-Chien Cheng Tags Invasion
- Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans
Authors Xin Wan, Geyu Liang, Dayong Wang Tags Accumulation , C. elegans , CPPDQ , Neurotoxicity Source
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
Authors Victoria H Wu , Bryan S Yung , Farhoud Faraji , Robert Saddawi-Konefka , Zhiyong Wang , Alexander
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
its potential for therapeutic targeting. " Authors Elena Tomas Bort , Megan Daisy Joseph , Qiaoying Wang
- Characterization, expressional and evolutionary analysis of five fish-specific CCRs (CCR4La, CCR4Lc, CCR12a1, CCR12a2, and CCR12b) in largemouth bass (Micropterus salmoides)
Authors Xiangyu Pi, Xuan Wei, Mingzhu Pan, Eakapol Wangkahart, Qihuan Zhang, Zisheng Wang, Zhitao Qi
- The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor
Authors Chenlin Feng, Rongfang Liu, Reno Brooks, Xuesong Wang, Willem Jespers, Marina Gorostiola González
- RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment
Authors Peng Kong , Xu Wang , Ya-Kun Gao , Dan-Dan Zhang , Xiao-Fu Huang , Yu Song , Wen-Di Zhang , Rui-Juan
- Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer
Rangasudhagar Radhakrishnan , Revathy Nadhan , Rohini Gomathinayagam , Muralidharan Jayaraman , Mingda Yan Srishti Kashyap , Kar-Ming Fung , Chao Xu , Resham Bhattacharya , Priyabrata Mukherjee , Ciro Isidoro , Yong Sang Song , Danny N Dhanasekaran Tags GPCR , High Grade Serous Ovarian Carcinoma , Let-7 miRNAs , Oncogenic
- Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia
Authors Peter J P Croucher , Maya Ridinger , Pamela S Becker , Tara L Lin , Sandra L Silberman , Eunice S Wang , Amer M Zeidan Tags AML , Biomarker , Hypomethylating agents , Onvansertib , PLK1 , Splicing
- Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone
Authors Hsuan Lung, Kelly L Wentworth, Tania Moody, Ariane Zamarioli, Apsara Ram, Gauri Ganesh, Misun Kang
- Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways
Authors Xin Miao , Gilbert Koch , Shichen Shen , Xue Wang , Jun Li , Xiaomeng Shen , Jun Qu , Robert
- Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning
Authors Chenshen Huang , Fengshuo Zhu , Hao Zhang , Ning Wang , Qi Huang Tags Cancer , Machine learning
- Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer
We detected the expression of GPR37 in NSCLC tissues and cell lines. Authors Han Liu , Yingjie Zhu , Huikun Niu , Jing Jie , Shucheng Hua , Xiaoxue Bai , Shuai Wang , Lei
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis
Authors Sun-Hee Hwang , Kevin Andrew White , Bandarigoda Nipunika Somatilaka , Baolin Wang , Saikat Mukhopadhyay