Alexander Hauser, Caroline Gorvin et al. for their research on GPCR gene variants and human genetic disease of glycosaminoglycans in GPCR signaling G protein-coupled receptor-mediated autophagy in health and disease organelles Reviews, GPCRs, and more G protein-coupled receptor (GPCR) gene variants and human genetic disease Heptares Doses First Subject in Phase 1 Trial with HTL0033744, an EP4 Agonist for Inflammatory Bowel Disease Ownership from GSK of HTL0027477, a Clinic-ready, First-in-Class Oral GPR35 Agonist for Inflammatory Bowel Disease

insights are made into the role of neuropeptides and their immunomodulatory functions in the healthy and diseased neuropeptides, receptor isoform-specific signaling events, and the inflammatory microenvironment in disease an increase in studies that have begun modulating neuropeptide activity for the treatment of corneal diseases focuses on the role of neuropeptides in maintaining the homeostasis of the ocular surface, alterations in disease

GRK2/β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including heart failure, cancer, and inflammatory diseases. cell function and focuses on the pathological implications of GRK2/β-arrestin2 in various inflammatory diseases

Aberrant EBI2 signaling is implicated in inflammatory bowel disease, sclerosis, and infectious disease oxysterol ligand and will facilitate the development of therapeutic approaches that target EBI2-linked diseases

Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease GPCRs arguably represent the most effective current therapeutic targets for a plethora of diseases The molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated complexity and compartmentalization, thus enabling a nuanced GPCR-based capacity to interdict multiple disease cellular activities implicates them as key controllers of the functional balance between health and disease

modulate inflammatory responses, offering potential therapeutic avenues for conditions such as autoimmune diseases exploring the roles of these receptors in various pathological states, including cancer and infectious diseases

The activation of mTOR complex 1 (mTORC1) is typically observed in human disease and continues to be Understanding the upstream regulators of mTORC1 will provide a crucial link to targeting mTORC1 hyperactivated diseases Statement mTORC1 is a master regulator of many cellular processes and is often hyperactivated in human disease molecular underpinnings of these pathways will undoubtedly be promising to the mTORC1 field and human disease

Implications of RGS protein dysregulation in disease: The Dysregulation of RGS proteins has been implicated in a range of diseases, including cardiovascular disease, pain, hypertension, and cancer. In cardiovascular disease, RGS proteins play a critical role in regulating blood pressure and vascular hypertension, dysregulation of RGS proteins has been shown to contribute to the pathogenesis of the disease The dysregulation of these proteins has been implicated in a range of diseases, and understanding the

Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine Receptor CXCR3 for Autoimmune Diseases seven-transmembrane G-protein-coupled receptor (GPCR) involved in various pathologies, in particular autoimmune diseases

Nichola J Smith's investigation: Gene expression of TAS1R taste receptors for cardiometabolic disease Taste Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease GPCRs in Neuroscience Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson's disease development GPCRs in Oncology and Immunology GPCRs and fibroblast heterogeneity in fibroblast-associated diseases

s Phase 1 study of CRN04894, the company’s investigational candidate for the treatment of Cushing’s disease both serum cortisol levels and 24-hour urine free cortisol excretion in the presence of sustained, disease-like

coupled receptors (GPCRs) for galanin have been discovered, which is the focus of efforts to treat diseases including Alzheimer’s disease, anxiety, and addiction.

technology with potential applications in chemical biology: a mini-review YAP/TAZ: Molecular pathway and disease therapy Primary cilia in skeletal development and disease Industry News Addex Reports 2023 Half Year Pharma to develop new therapies for people living with obesity, diabetes and other serious metabolic diseases

September 2022 "Systemic sclerosis (SSc) is a systemic autoimmune disease with the key features of inflammation Extracellular vesicles are another novel player to possess disease processes.

mechanistic computational approach that couples drug pharmacokinetics/pharmacodynamics and the course of disease It has begun to play important roles in drug development for complex diseases such as cancer, including

Matthew Eddy , et al. for their investigation on Interaction Networks within Disease-Associated GαS receptor endocytosis generates spatiotemporal bias in β-arrestin signaling Interaction Networks within Disease-Associated Industry News Nxera Pharma Receives US$10 Million from AbbVie as Collaboration Targeting Neurological Diseases

international leaders in GPCRs pharmacology, immunology, drug discovery and development for auto-immune diseases

as sensory perception, reproduction, development, growth, metabolism, and are also linked to major diseases , such as neuroinflammatory, metabolic and autoimmune diseases. GPR84 has been additionally proposed to be a potential biomarker in different inflammatory diseases ( GPR84 is a promising target to exploit and the investment in better tools to study its function in both disease

The sheer complexity of the cell and the astonishing diversity of diseases are just two reasons why researchers typically require years to uncover the mechanisms of disease before they can even dare to contemplate

signaling pathway has captured an increasing amount of attention because of its involvement in various diseases , such as idiopathic pulmonary fibrosis, cancers, cardiovascular diseases and neuropathic pain, making development targeting LPA receptors to modulate LPA signaling and their therapeutic potential in various diseases

This high-resolution mapping can confirm the protein’s role in disease pathology and highlight allosteric Resistance A significant challenge in drug development, particularly in the treatment of infectious diseases systems, including multicellular organisms and human cells, to better mimic physiological conditions and disease

Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease The prevalence of non-alcoholic fatty liver disease (NAFLD) is globally increasing. Gaining control over disease-related events in non-alcoholic steatohepatitis (NASH), an advanced form

Repurposing Vaptans "Men with advanced prostate cancer are treated by androgen deprivation therapy but the disease cancer patient sample data revealed that coexpression of AVPR1A and AVPR2 is highly correlated with disease

August 2022 "Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (

tyrosine kinase IGF1R and its associated GPCRs are co-regulated by the noncoding RNA NEAT1 in Alzheimer's disease characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer's disease assays Generation of a deep mouse brain spectral library for transmembrane proteome profiling in mental disease

multiple sclerosis patients Multiple sclerosis (MS) is a specific type of chronic immune-mediated disease Despite intensive research, a known treatment for MS disease yet to be introduced. Thus, the development of novel and safe medications needs to be considered for the disease management

global biopharmaceutical company developing novel oral therapeutics to treat a wide range of chronic diseases

receptor (GPCR) GPR35 is involved in oncogenic signaling, bacterial infections, and inflammatory bowel disease transducer interactions and allow for mechanism-based therapies against, for example, inflammatory bowel disease