research laboratory of around 15 staff supported by basic research grants investigating aspects of disease biology and the action of drugs in the context of disease.

and pharmacology aiming to understand the role of WNT/Frizzled signaling in biology, physiology, and disease find, create and optimize Frizzled-targeting small molecule drugs to improve future therapies of human disease

, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular disease They highlighted the importance of fine-tuning the approach to suit different diseases and interdisciplinary The discussion also emphasized the need for a disease-specific approach, considering the clinical context Arthur and Yamina discussed the potential of autoantibodies and allosteric modulation in the context of disease

His clinical focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center

the investigation of the regulation of G protein-coupled receptors signaling mechanisms in health and disease investigating the role of metabotropic glutamate receptor signaling in Huntington’s and Alzheimer’s disease

and obtained a PhD in Molecular Medicine and a Clinical Specialisation in Endocrinology and Metabolic Disease protein-coupled receptor (GPCR) signalling and their alterations in endocrine, metabolic and cardiovascular diseases

laboratory has gained valuable insights into the genetic basis and pathophysiology of lymphatic vascular disease , preeclampsia and sex-dependent cardiovascular disease.

during prolonged cold exposure Anastasia Georgiadi ADGRF5-mediated regulation of cardiac health and disease Netherlands; 2Department of Experimental Immunology, Amsterdam institute for Immunology and Infectious diseases Georgiadi on the web Endocrine Pharmacology Google Scholar ADGRF5-mediated regulation of cardiac health and disease

gained experience in the identification and characterization of llama-derived antibodies in inflammatory diseases conformations, while also focusing on their therapeutic potential in oncology and transplant infectious disease

In particular, the association of the disease with several types of anti-G protein-coupled receptor ( To date, POTS is recognized as one of the sequelae of coronavirus disease 2019 (COVID-19) and its frequency

the investigation of the regulation of G protein-coupled receptors signaling mechanisms in health and disease investigating the role of metabotropic glutamate receptor signaling in Huntington’s and Alzheimer’s disease

intestinal stem cells to exacerbate colitis Published date May 21, 2024 Abstract "Inflammatory bowel disease Wang , Xinyang Song , Shu Zhu , Wen Pan Tags Enterococcus , IBD , ISCs , colitis , inflammatory bowel disease

laboratory has gained valuable insights into the genetic basis and pathophysiology of lymphatic vascular disease , preeclampsia and sex-dependent cardiovascular disease.

However, the underlying mechanism of virus-cancer immunological interaction during disease pathogenesis comprehensive proteogenomic characterization of natural killer/T-cell lymphoma (NKTCL), a representative disease

inflammation Published date December 12, 2023 Abstract "Chronic inflammation is the underlying cause of many diseases , including type 1 diabetes, obesity, and non-alcoholic fatty liver disease.

elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors exhibited decreased disease-specific survival (DSS) and disease-free survival (DFS) compared to those with low RGS16 expression.

This axis is linked to diseases like HIV/SIV, cancer, and COVID-19. CXCR6 in chickens may have altered CD8 TRM cell abundance, with implications for immunity against viral diseases

directed migration (also referred to as chemotaxis) is a common pathogenic mechanism of inflammatory diseases have implications for therapeutically targeting TIPE proteins in human inflammatory and autoimmune diseases

Much of his work is based on GPCR signaling in the context to cardiovascular diseases.

More Friday, November 3rd / 9:20 AM Cannabinoid compounds to augment L-DOPA treatment in Parkinson's Disease and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Friday, November 3rd / 11:05 AM Biased agonism at the GLP-1 receptor: from structure to animal models of disease Columbia Read More Friday, November 3rd / 2:10 PM Genetic Deletion of Atypical VGLUT3 Rescues Huntington’s Disease

the identification of drugs targeting the unique aGPCR receptor family and customize the method for disease-relevant recruited by Vertex Pharmaceuticals (Canada) where he worked on biomarker discovery for inflammatory bowel disease and small molecules drug discovery for polycystic kidney disease. novel pharmacological targets and contribute to the development of innovative treatments for a range of diseases

September 14, 2021 at 2:00:00 PM Learn More >> GPCRomics: Identifying novel GPCR targets in health and disease human GPCR to create self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease More >> Phosphorylation of the M1 muscarinic acetylcholine receptor protects from neurodegenerative disease

in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases She is currently working to understand the signaling and degradation of GPCRs in disease states to help

My group studies the spatiotemporal dynamics of atypical inflammation and the control of disease progression

and clinical pharmacology as scientist or PI in neonatal lupus, Cardiomyopathy, hypertension, chagas disease

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Diseases

findings propose a therapeutic potential in combined CXCR4 and LPA1 inhibitors for cancer and inflammatory diseases receptor 4 , Chemotaxis , G protein-coupled receptor , GPCR heteromer , GPCR signaling , Inflammatory disease

In 1983, he joined the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the