Search Results
40 items found for "Megan Othus"
- The sixth transmembrane region of a pheromone G-protein coupled receptor, Map3, is implicated in ...
Thus, the differences in these two GPCRs might reflect the significantly distinct stringency/flexibility
- Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion ...
Thus, the development of novel and safe medications needs to be considered for the disease management
- Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans
Thus, ascaroside signaling promotes axon regeneration by activating the GPCR-Gqα pathway.
- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
HH binding leads to the dislocation of PTC1 from the cilia, thus making way for SMO to localize in the
- G protein-coupled receptor kinase 2 is essential to enable vasoconstrictor-mediated arterial ...
vasoconstrictor-driven VSMC proliferation through its ability to promote efficient prolonged PI3K-Akt signalling, and thus
- Self-docking and cross-docking simulations of G protein-coupled receptor-ligand complexes
However, blind assessments of ligand pose quality and affinity prediction have thus far not provided
- Synaptic integration of subquantal neurotransmission by co-localized G protein coupled receptors in
Thus, stimulus trains in 5-HT1B receptor agonist unveil dynamic synaptic modulation and a sophisticated
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
Thus, this finding raises the possibility that GPCR priming might result not only from intricate receptor-G
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial ...
Besides, β-arrestin-2 can stimulate PP2A to dephosphorylation Smad3 (inhibition) and GSK3β (activation), thus
- Chemokine receptor-targeted drug discovery: progress and challenges
development of biased ligands, which promote the engagement of the receptor with a certain effector, thus
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
they are present at saturating concentrations; 3) neutral antagonists have null intrinsic efficacy, thus
- Decoding β-Arrestins: from Structure to function
Thus, exploring large-scale protein-protein interaction datasets could shed light on connections between