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46 items found for "Meghana S Pagadala"
- Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors
Authors Felix S Seibert , Ulrik Stervbo , Lea Wiemers , Sarah Skrzypczyk , Maximillian Hogeweg , Sebastian
- Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation
Authors Magdalena B Flak , Duco S Koenis , Maria Gonzalez-Nunez , Ana Chopo-Pizarro , Jesmond Dalli Tags
- Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia
Aguilar, Lauren Hagen, Jeannine McCune, Richard Gelinas, Raymond J Monnat Jr, Ilya Shmulevich, Pamela S
- LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice
and, together with its excellent specificity, safety and stability, warrant further evaluation of LP2's
- CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation
This work focussed on exploring the functions and mechanism of circFKBP5 in DPSC dysfunction evoked by differentiation of hDPSCs was investigated by performing alkaline phosphatase (ALP) staining and alizarin red S
- Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney fibroblasts
L Advani , Phelopater Sedrak , Laurette Geldenhuys , Karthik K Tennankore , Penelope Poyah , Ferhan S
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
The results provide rationale for considering a combination(s) of FDA-approved SFK (dasatinib) and MEK
- High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases
GPCRs in Oncology and Immunology High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism
- Ep 66 with Dr. Antony A. Boucard Jr
Boucard´s lab focuses on molecular and cellular mechanisms underlying the function of adhesion GPCRs
- Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells
Authors Trang T T Nguyen , Wen Lu , Wandi S Zhu , K Mark Ansel , Hong-Erh Liang , Arthur Weiss .
- Session IV | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Assistant Professor in the Department of Neuroscience at Baylor College of Medicine, where he studies BAI1's
- GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
To determine GPR68 inhibition's mechanism of cell death we use DAVID pathway analysis of RNAseq. Authors Charles H Williams , Leif R Neitzel , Jessica Cornell , Samantha Rea , Ian Mills , Maya S Silver
- Student Flash Presentations | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Metabolism, Nervous System, Proteomics and Transcriptomics, Receptor Structure, Signaling and Activation Mechanism Louis, 660 S. Euclid Ave, St. Louis, MO 63108, USA. Park B, Mohamed M, Li H, Elkholy A, Torrelli-Diljohn A, Kim JH, Jeong K, Murphy JM, Harvey CA, Dunlap S, James Bridges at National Jewish Health in Denver, CO researching molecular mechanisms of lung injury The current methods for testing KCC-07’s ability to reactivate ADGRB1 expression involve western blotting
- [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts]
gingival fibroblasts] Published date March 27, 2024 Abstract "Objective: To clarify the effect and the mechanism Authors Y H Hu , L L Shang , S H Ge Source Contribute to the GPCR News Coming soon Become a Contributor
- Dr. GPCR Summit 2021 Live Talks
Ben Myers September 13, 2021 at 6:00:00 PM Learn More >> The Phosphorylation Barcode as a Mechanism of Biased β-arrestin 2 Recruitment and Conformation at CXCR3 Dylan S. Eiger September 13, 2021 at 7:00:00 PM Learn More >> A distinct activation mechanism in GPCR dimers: Meriem Semache September 15, 2021 at 2:00:00 PM Learn More >> GPCR activation mechanisms across classes
- Ep 151 with Dr GPCR Board
My experience in basic research at several universities worldwide and early R&D at Novo Nordisk A/S allowed PARs are GPCRs that are activated through an atypical irreversible proteolytic mechanism. She has made numerous important discoveries related to the mechanisms that control PAR1 signaling and
- Session V | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Session V Structural mechanisms The autoproteolytic mechanism has been previously proposed, but remains to be validated. protein regions, whose dynamics mediate solvent-accessibility of the catalytically active GPS triad HL|S/ Using a multiscale QM/MM approach - combining computational quantum mechanics with classical molecular dynamics - to study the GAIN domain cleavage mechanism of ADGRL1 reveals the sequence of events at the
- Session I | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
in AGPCRs Signaling Properties of ADGRL3 Signe Mathiasen An ECR-Mediated and TA-independent Mechanism Because the TA-mediated mechanism is a “one and done” mechanism that is irreversible and prevents the ECR-mediated mechanism opens new possibilities for drugging aGPCRs. Jose Rizo-Rey as a graduate student to elucidate the mechanisms of neurotransmitter release. Jones (Harvard Medical School); Jeffrey S.