TkR99D in fruit flies, as a potential therapeutic target for alleviating renal tubular dysfunction in mice

Michael Lemieux ''My name is Michael (Mike) Lemieux and I am a Connecticut native.

GPR50 expression was observed to be significantly increased in the adipose tissue of obese T2DM mice,

In in vivo set-up, weekly intraperitoneal administration of Peptidase M84 in syngeneic mice significantly

Antigen exposure in mixed-chimeric Ccl5-, Ccr2-, Ccr5-, Ccr7-, and Batf3-deficient mice demonstrated

tyrDC-deficient Enterococcus faecalis strain and intestinal epithelial cell-specific Adra2a knockout mice

established the applicability of our zebrafish findings to mammals by showing that macrophages of Ltb4r2-/- mice

Through gain- and loss-of-function studies in mice, we show that GPR143 promotes metastasis by secreting

We also developed transgenic mice expressing a chemogenetic CD8-restricted Gαs-DREADD to activate CD8

Here, we identify C5aR1 and CXCR4 as direct Norbin interactors and used mice with myeloid-Norbin deficiency

lanthionine-constrained agonist of angiotensin II type 2 (AT2) receptor inhibited PDX of colorectal cancer in mice

Metabolism 2023), recognition of amine containing hormones by GPCRs (Cell 2021, 2023, Nature 2023b), bile

germline Tp53 deletion) with a second floxed allele under the control of Nestin-Cre was crossed to Bai3-/- mice Immunoblots on wild-type and Adgrb1 exon 2-deleted mice, reverse transcription PCR and promoter-luciferase We performed single-nucleus RNA sequencing on male and female kidneys. snRNAseq revealed abundant, cell-specific Restoration of ADGRB1 expression slowed tumor growth and improved survival in mice bearing MB xenografts

Attendees will be provided with Prism files, Excel templates and simulators, and the PowerPoints of the

Methods: RGS5 knockout (Rgs5-KO) mice and RGS5 overexpression or knockdown in VSMCs in vivo by adeno-associated

formation by PDAC cells and suppressed the growth of Mia PaCa-2 cells xenografted into the flank of nude mice

intratumoral administration of the ADC in patient-derived GBM xenografts in the brain of immunodeficient mice resulted in significant reduction of tumor growth and prolongation of survival of host mice.

inhibitory function of Pc(4-4) is demonstrated via inhibition of ovarian cancer peritoneal spread in mice

the optimization of longitudinal intravenous self-administration paradigms for genetically modified mice

prostatic hyperplasia (BPH) are inflammations of the prostate gland, which surrounds the urethra in males Database-driven data mining and networking were utilized to establish a general correlation between Jinqiancao

less primary human T lymphocyte chemotaxis in vitro and peritoneal ingress of CXCR3+ T lymphocytes in mice

the optimization of longitudinal intravenous self-administration paradigms for genetically modified mice

Administration , VIP , Vasoactive intestinal peptide , Voltage-gated sodium channel , gamma chain , mAb , mIgE