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59 items found for "Mou-Wang Zhou"
- Cancer Research UK and Sosei Heptares sign agreement to advance cancer immunotherapy candidate ...
candidate into clinical trials "HTL0039732 is a novel EP4 antagonist with potential to treat a wide range
- G protein-coupled receptor signaling: transducers and effectors
"G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range
- G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions...
GRK2/β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including
- AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors
August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide range
- Hear the sounds: the role of G protein-coupled receptors in the cochlea
G protein-coupled receptors (GPCRs) are crucial receptors that regulate a wide range of physiological
- Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range
- Immunomodulatory Role of Neuropeptides in the Cornea
Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells.
- β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
GPCRs respond to a wide variety of signals that range in size from photons to proteins (Foord et al.,
- In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
Hence, it has wide applicability across a spectrum of neuroscience research, ranging from the study of
- Cholesterol-Dependent Dynamics of the Serotonin 1A Receptor Utilizing Single Particle Tracking....
2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range
- Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: ...
Modes "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range
- Newly launched antibody libraries put hard-to-drug targets within reach
The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.
- Targeted Therapies to Reduce Side Effects in Modern Drug Development
Modern drug development approaches include a range of techniques leveraging structural biology, immunology
- Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...
fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
fragment- and seven lead-like compounds were confirmed to bind to the allosteric site with affinities ranging
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
diseases, (d) showed spontaneously fluctuating Ca levels from approximately normal to near fatally high ranges
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
fragment- and seven lead-like compounds were confirmed to bind to the allosteric site with affinities ranging
- Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface
We show that besides classical hydrogen bonds, weak polar interactions such as O-HC, O-Br, and long-range
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
Nevertheless, the GloSensor™ cAMP assay can be applied to analyze signaling by a wide range of GPCRs
- A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr
Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled
- The development of modulators for lysophosphatidic acid receptors: A comprehensive review
Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities
- GPCRS: AN ODYSSEY FROM STRUCTURE, SIGNALING AND REGULATION TO THERAPEUTICS
Coupled with their ability to respond to a highly diverse range of chemical stimuli, they represent the
- Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans
Chemical communication controls a wide range of behaviors via conserved signaling networks.
- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
Consequently, the dynamic range for IL-6 detection as an assay for β-alanine-mediated activation of MRGPRD
- Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the ...
Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the range of
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
could unveil new dimensions of GPCR functionality and offer innovative approaches to treating a wide range
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
However, the receptors that these medicines target have been described as the ‘low-hanging’ fruit, and There are approximately 800 human GPCRs in the superfamily, controlling a broad range of physiological Orion’s receptor antagonist analogs have demonstrated powerful efficacies across a range of animal models
