Search Results
70 items found for "Multiple myeloma"
- Allosteric modulation of GPCRs: From structural insights to in silico drug discovery
determination of GPCRs bound to different types of allosteric modulators have led to the identification of multiple
- Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms
Multiple 14-3-3 isoforms exist, and a GPCR can differentially interact with different 14-3-3 isoforms
- Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal GPCR
Collaboration is part of Sosei Heptares ’ Target Identification and Validation (TIV) strategy to leverage multiple
- Targeted Therapies to Reduce Side Effects in Modern Drug Development
As this article shows, progress is being made on multiple fronts."
- To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
In this study, a DOR agonist ADL5859 was docked to the inactive DOR and multiple microsecond molecular
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
emphasizes the importance of the Gi/o (pertussis toxin-sensitive G proteins, whose βγ subunits activate multiple
- G protein-coupled receptors that influence lifespan of human and animal models
Humanity has always sought to live longer and for this, multiple strategies have been tried with varying
- Combined docking and machine learning identify key molecular determinants of ligand pharmacological
We computationally docked ~2700 known β2AR ligands to multiple β2AR structures, generating ca 75 000
- Crinetics Pharmaceuticals announced the formation of an independently operated new company...
Drug Candidates and Leads Against 10 Oncology Targets – Radionetics and Crinetics to Collaborate on Multiple
- Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS-7 cells...
activated by GnIH peptides in teleosts, and represent a starting point for the study of interactions with multiple
- Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
The multiple downstream signaling pathways are still poorly understood.
- A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr
This model suggests that Fgr interacts with arrestin-3 at multiple sites and is consistent with the locations
- β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
signaling complexes, which not only serve to desensitize GPCRs by internalization, but also mediate multiple
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
The only other farnesylated G-protein γ-subunit, Gγ11 ( Gng11 ), is expressed in multiple tissues but
- GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral...
Knockdown of GPR125 as well as that of Dlg1 results in formation of aberrant cysts with multiple lumens
- Coordinated transcriptomics and peptidomics of central nervous system identify neuropeptides and ...
Neuropeptides and their specific receptors (primarily G protein-coupled receptors, GPCRs) regulate multiple
- GPCRS: AN ODYSSEY FROM STRUCTURE, SIGNALING AND REGULATION TO THERAPEUTICS
this complexity raises further fundamental questions and challenges in the study of GPCR action in multiple
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
DL algorithms employ artificial neural networks with multiple layers of interconnected nodes which learn AI is providing a dramatic acceleration of the drug discovery process at multiple stages: 1. Multi-target drug design: GPCRs are often involved in complex signaling networks. AI algorithms can integrate data from multiple sources, including genomics, proteomics, and pharmacological databases from experimental labs and new AI techniques will allow more associations and will promote multi-task
- GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between ...
tissue complexity and compartmentalization, thus enabling a nuanced GPCR-based capacity to interdict multiple
- Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic ...
In this review, we describe the functions of multiple GPCRs expressed in HSCs, their roles in liver fibrogenesis
- G protein-coupled receptor interactions and modification of signalling involving the ghrelin ...
In vitro and in vivo data suggest that GHSR1a heterodimerises with multiple G protein-coupled receptors
- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
interactions of cholesterol with lower TM cholesterol-binding domains are governed by the presence of multiple
- Exploring the Breakthroughs in GPCR Research
of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid for secondary metabolite production in yeast Reviews, GPCRs, and more Class B1 GPCRs: Insights into Multi-Receptor
- Self-docking and cross-docking simulations of G protein-coupled receptor-ligand complexes
Simulations were performed using 37 experimental structures of 11 Class A GPCR crystallized in multiple
- Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the ...
Therefore, neuronal Gα proteins of GOA-1, GSA-1, and GPA-10 functioned to transduce signals of multiple
- 📰 GPCR Weekly News, May 22 to 28, 2023
Multiple Subthreshold GPCR Signals Combined by the G-Proteins Gαq and Gαs Activate the Caenorhabditis
- 📰 GPCR Weekly News, January 15 to 21, 2024
transdifferentiation GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid
- 📰 GPCR Weekly News, October 30 to November 4, 2023
study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid vertebrate photoreceptor outer segments Industry News Sosei Heptares Will Receive US$3.75 Million Payment in Multi-Target