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54 items found for "Neel Freedman"
- Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion ...
Thus, the development of novel and safe medications needs to be considered for the disease management
- 📰 GPCR Weekly News, October 2 to 8, 2023
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- 📰 GPCR Weekly News, June 12 to 18, 2023
Confo Therapeutics and AbCellera partner on GPCR-targeting antibodies GPCR Inhibition With ICB May Be Needed
- 📰 GPCR Weekly News, October 9 to 15, 2023
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- Decoding β-Arrestins: from Structure to function
question of whether β-arrestin1 and 2 serve overlapping or distinct functions remains, raising the need Nonetheless, there is an ongoing need to delve deeper into the intricate mechanisms governing GPCR activation
- All Aboard the GPCR Express: Your Weekly Update is here! Oct 14-20, 2024
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- 📰 GPCR Weekly News, July 24 to July 30, 2023
Science Crinetics Hosting Key Opinion Leader Webinar To Discuss The Current Treatment Landscape And Unmet Need
- 📰 GPCR Weekly News, September 18 to 24, 2023
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- VAMP2: a crucial player in the delivery of MOR to the synapse
been well characterized, the mechanisms that modulate the delivery of GPCRs to the membrane cell still need
- Discover the Hottest GPCR News of the Week: Oct 7-13, 2024!
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- 📰 GPCR Weekly News, January 8 to 14, 2024
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- 📰 GPCR Weekly News, January 1 to 7, 2024
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- Unlocking the Future of Medicine: Advancements in GPCR Research
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- 📰 Breaking Down the Latest GPCR Discoveries: a Weekly Update (Nov 27-Dec 3, 2023)
Neil Grimsey and Dr. Katarzyna Marcinkiewicz.
- 📰 GPCR Weekly News, November 20 to 26, 2023
Neil Grimsey and Dr. Katarzyna Marcinkiewicz.
- 📰 GPCR Weekly News, April 22 to 28, 2024
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- 📰 GPCR Weekly News, April 15 to 21, 2024
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- Chemokine receptor-targeted drug discovery: progress and challenges
feature of the chemokine system (Nedjai et al. 2012), but more research in different cellular contexts is needed
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
opioid receptors were shown to constitutively activate Gi proteins in a membrane preparation without the need
- New role of β-arrestins in MOR signaling
Opioids are analgesic drugs consumed non-medically for euphoric feelings and medically for pain relief
- Odorant receptors – a bit of smell for drug discovery
In order to target ectopic ORs there is a need to identify selective agonists or antagonists, where the
- 📰 GPCR Weekly News, May 6 to 12, 2024
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- Overview of adhesion GPCRs self-activation
complexes with Gs, Gi, Gq, and G12, where like other GPCRs, the distal αH5 region of the G protein was needed
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
Volpe et al. 2012); it dampens the inflammatory response when needed (C. A. H.
- Glyco-sulfo hotspots in the chemokine receptor system
Further research will be needed to boost our understanding on the dynamics and biological relevance of
- Ode to GPCRs
Much more need to be uncovered about bias signaling, tissue-specific GPCR activation profiles, compartmentalized