He has focussed on developing a comprehensive map of ovarian cancer essential genes using whole genome Several of these targets are being developed for potential new therapeutic strategies in ovarian and

mispronunciations, cultural differences, and the importance of a multidisciplinary approach in drug development discussed their research interests, particularly in the field of GPCR, and the importance of method development discussed their professional backgrounds, highlighting the benefits of a multidisciplinary approach in drug development They also highlighted the importance of method development, integrity, and honesty in scientific research

properties of these new ligands are deemed exceptional, a lead optimization is realized and its therapeutic development

protein-coupled receptors (GPCRs) mediate a wide spectrum of physiological functions, including the development signaling was hyper-activated in osteoblastic cell lineages using an engineered receptor strategy, developed

discussed the importance of hiring based on differentiation, impact, and interest, the need for workforce development will share notes about PRISM and presentability with Arthur. - Arthur will share the story of PRISM's development Lastly, they discussed the growth and development of the Monash Institute of Pharmaceutical Sciences, significance of fundamental discoveries, the role of biotech, and the need for efficiency and process development They also discussed the disruption within the pharmaceutical sector, the importance of workforce development

Robert Laprairie is an Associate Professor and the Saskatchewan Research Chair in Drug Discovery and Development

They also discussed the ongoing developments in the GPCR field, the upcoming adhesion GPCR consortium He explained that initially, the field lacked adequate tools, and his lab had to develop new techniques Yamina expressed her appreciation for Demet's work and asked about the development of the GPCR field GPCR Field and Naming Convention Discussion Demet and Yamina discussed the ongoing developments in the

Work from our lab showed that the PCP components, including ADGRC2 and ADGRC3, are localized in the developing My research focus is the mechanisms of neural circuit development, function and disease." To exploit this expression profile, we have developed antibody-drug conjugates (ADCs) targeting CD97, oncogenesis in glioblastoma, the most common brain malignancy, and chromatin organization in human neural development

His lab focuses on developing and innovating technologies to solve broad questions in pharmacology, with

He also discovered and championed a novel prostaglandin EP4 drug candidate for development.

The conversation ended with Arthur's ongoing research and his development of a new operational model. Allosteric Modulation and Hybrid Molecules Arthur and Yamina discussed the development of an operational also discussed the potential of certain drugs, like flumazenil, as 'nails' or compounds that could be developed and Reproducibility Yamina and Arthur discussed the concept of a target product profile (TPP) in drug development

To address this, we developed the NTF release sensor (NRS), a genetically encoded reporter that facilitates latrophilin-type aGPCR Cirl/ADGRL in Drosophila, revealing NTF release and receptor dissociation within the developing In addition, the platform was used to develop assays for high-throughput screening for challenging adhesion research aims to leverage this knowledge to identify novel pharmacological targets and contribute to the development

medicinal chemist in Italy, followed by a Ph.D. in computational medicinal chemistry, during which she developed

We have developed an array of fluorescent biosensors to map kinase activity in living cells and are exploring

She developed expertise over the past two decades studying structure/function relationships of GPCRs

co-founder of Heptares Therapeutics , now called Sosei Heptares , a GPCR-focused drug discovery and development

She is an internationally recognized biophysicist for her contributions in developing constrained molecular

orchestrate tumor immunobiology at three main levels: tumor immunity, cancer cell expansion, and blood vessel development

Brian has contributed to the discovery or development of 5 marketed drugs through his work spanning molecular

David Tuveson at CSHL where he participated in the development of an organoid system for the culture normal and malignant pancreatic tissue, allowing advances in sequencing, target discovery and biomarker development He also continued his interest in computational analysis of cancer drivers by co-developing GECCO, an Mike shared his strategy of developing preliminary projects and gathering data to strengthen his application

The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic development

deciphering of cellular and organ functions, which require individual adhesion GPCRs, and extends to the development

Professor Pfleger has developed extensive expertise in profiling receptor binding and function at the

I am continuing with the development of advanced screening approaches in the Madan Babu lab to progress

His group recently developed an online resource of biased ligands and pathway effects to advance the

During a joint postdoc with John W Daly at NIH and Solomon Snyder at Johns Hopkins, he developed the

He has developed innovative methods for in-cellulo measurement of protein-protein interactions, receptor

This may help to develop more potent ligands for the treatment of inflammatory related diseases."