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107 items found for "Roland B Walter"
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
divided into six classes based on amino acid sequence similarities, but only four of the classes (A, B,
- 📰 GPCR Weekly News
GPCR Activation and Signaling Molecular Mechanisms of PTH/PTHrP class B GPCR Signaling and Pharmacological GRK5 Deficiency in the Hippocampus Leads to Cognitive Impairment via Abnormal Microglial Alterations.
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
B. Nibbs et al. 2013). Volpe et al. 2012; B. N. Zhao et al. 2019). internalization of CCR2 was shown to be G protein-independent by a “prelabel” flow cytometry assay (B.
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
characteristics with the 2 cases we previously reported as follows: (a) elderly (74-87 years at diagnosis), (b)
- Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs)...
RGS20 was strongly upregulated in tumor tissue compared with adjacent normal tissue of HCC patients; (b)
- Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR..
mechanisms of a middle-sized flexible molecule, bosentan, to a GPCR protein, human endothelin receptor type B
- Decoding β-Arrestins: from Structure to function
Recently, Maharana et al. determined multiple structures of activated b-arrestins in complex with the using cryo-EM, and discovered a significantly conserved phosphorylation motif in GPCRs that drives b-arrestin Such alterations can also extend to β-arrestin expression levels, potentially affecting the composition In certain cancer types, only one β-arrestin isoform's expression may be altered, while the other remains
- 📰 GPCR Weekly News, January 29 to February 4, 2024
Gunnar Schulte et al. on the study of the interaction of Clostridioides difficile toxin B and FZD7. development Structural and functional insight into the interaction of Clostridioides difficile toxin B
- Ode to GPCRs
Gertrude B. Gertrude B. Press release: The 2004 Nobel Prize in Physiology or Medicine to Richard Axel and Linda B. Linda B. Plouffe, B., Thomsen, A. R. B. & Irannejad, R.
- 📰 GPCR Weekly News, September 25 to October 1, 2023
glucose sensor for substrate-dependent secretion and display of cellulose-degrading enzymes Functional Water CXCL12-induced signaling and cell migration Respiratory infections predominate after day 100 following B-cell
- Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through...
Induces Behavioral Hypersensitivity through Mitogen-Activated Protein Kinase and Nuclear Factor- κ B
- Targeting Intracellular Allosteric Sites in GPCRs
neutral allosteric ligands (NALs), binding to a receptor's allosteric site without causing any detectable alterations where the resulting change in conformation can influence the orthosteric binding pocket, potentially altering GPCR therapeutics, with the discovery of an intracellular allosteric site common in class A and class B
- G protein-coupled receptor kinase 2 is essential to enable vasoconstrictor-mediated arterial ...
GPCR signalling through phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) promotes VSMC proliferation
- 📰 GPCR Weekly News, October 2 to 8, 2023
like effects on mouse metabolism Development, synthesis and evaluation of novel fluorescent Endothelin-B
- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
pathway, which results in an IkB kinases (IKK)-mediated canonical activation of nuclear factor kappa-B
- 📰 GPCR Weekly News, July 10 to 16, 2023
Industry News Septerna Secures $150 Million in Series B Financing to Advance Pipeline of Novel GPCR-targeted
- 📰 GPCR Weekly News - January 2 to 8, 2023
GPCRs in Neuroscience Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane
- Regulators of G-protein signaling: essential players in GPCR signaling
specific and tightly regulated; mutations in the RGS domain and other structural motifs have been shown to alter RGS4 is expressed in various immune cells, including T cells and B cells, and has been shown to modulate
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
., Structural insights into differences in G protein activation by family A and family B GPCRs.
- 📰 GPCR Weekly News, January 30 to February 5, 2023
Computational investigation of functional water molecules in GPCRs bound to G protein or arrestin. SLAS 2023 B uilding Biology in 3D Symposium.
- 📰 GPCR Weekly News, February 13 to 19, 2023
SLAS 2023 B Building Biology in 3D Symposium.
- 📰 GPCR Weekly News, February 6 to 12, 2023
SLAS 2023 B Building Biology in 3D Symposium.
- Dr. GPCR University registration is now open! Secure your spot now!
short-lived GPCR oligomers in live cells Industry News Confo Therapeutics Announces EUR 60M Series B
- 📰 GPCR Weekly News, September 4 to 10, 2023
ozone-induced stress response in male Wistar Kyoto rats Reviews, GPCRs, and more Understanding class B
- 📰 GPCR Weekly News, May 8 to 14, 2023
GPCRs in Cardiology, Endocrinology, and Taste Molecular Mechanisms of PTH/PTHrP Class B GPCR Signaling
- 📰 GPCR Weekly News, July 31 to August 6, 2023
Activation and Signaling GPCR activation and GRK2 assembly by a biased intracellular agonist Conserved class B
- 📰 GPCR Weekly News, June 26 to July 2, 2023
Development, synthesis and evaluation of novel fluorescent Endothelin-B receptor probes.
- 📰 GPCR Weekly News, February 27 to March 5, 2023
Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in