. - Arthur will work on designing ligands for specific receptors, aiming to create biased agonists for and Drug Discovery Yamina and Arthur delved into the complexities of protein-protein interactions, specifically The discussion also emphasized the need for a disease-specific approach, considering the clinical context

focuses on developing and innovating technologies to solve broad questions in pharmacology, with a specific

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IGGi-11 binding to G-protein α-subunits (Gαi) specifically disrupted their engagement with GIV/Girdin

Here we interrogate the role of GPR68 specifically in GBM cells using a novel highly specific small molecule Importantly, OGM was not-acutely toxic to zebrafish and its inhibitory effects were found to spare non-malignant provide a promising therapeutic approach to selectively induce ferroptosis in glioblastoma cells while sparing

presently a professor at the Department of Pharmacology and Toxicology at the University of Otago after spending

focuses on understanding the fundamental cell biological mechanisms regulating GPCR activity, including spatial She obtained a PhD in Biochemistry from University College London and spent several years in Switzerland

David has over 20+ years of experience working in a drug discovery environment mainly in a specialist His current interests include the development of HTS fluorescence-based kinetic binding assays specifically

fibrotic bone Published date May 1, 2024 Abstract "G protein-coupled receptors (GPCRs) mediate a wide spectrum The Wnt signaling pathway has been implicated in the pathogenesis of FD-like bone, but the specific Wnts

The results demonstrated that GNAI family genes, specifically GNAI3, were significantly associated with

Gainetdinov is the Institute of Translational Biomedicine Director at Saint Petersburg State University (SPBU Before SPBU, Raul R.

Specifically, the review highlights five GPCRs able to orchestrate tumor immunobiology at three main to harness the full potential of GPCR-targeted treatments, by applying a multireceptor and patient-specific

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receptors such as trace amine-associated receptors (TAARs), formyl peptide receptors (FPRs), and membrane-spanning

deal of challenges given that they are highly polymorphic proteins expressed as various alternatively spliced His lab highlighted the importance of splicing events in biasing latrophilins’ regulation of cyclic AMP

RGS16 protein level in CRC, and found that patients with RGS16-high tumors exhibited decreased disease-specific

During his master's studies, he specialized in Biomedical Biotechnology and Structural Biology/Biochemistry group and used this platform to develop nanobodies targeting viral G protein-coupled receptors with a special

, displayed almost no abnormalities in myeloid cell differentiation and compartmentalization in the spleen encephalomyelitis, an autoimmune disease model for multiple sclerosis, with increased inflammation in the spinal dendritic cells, and CD4+ T cell infiltration into the experimental autoimmune encephalomyelitis-induced spinal purified from Gpr141 -/- mice increased cytokine production of myelin oligodendrocyte glycoprotein 35-55-specific

CELSR1 (ADGRC1) In Breast Cancer Caroline Formstone Generation and characterization of collecting duct specific To test the specific hypothesis that biased expression of CELSR1 isoforms will predict invasive potential Formstone on the web University of Hertfordshire Generation and characterization of collecting duct specific This mouse model will be useful to delineate the collecting duct-specific role of GPR56 for renal function In medulloblastomas (MB), BAI3 (ADGRB3) expression is specifically reduced in the WNT-activated group

In fact, KLK3 is the specific prostate antigen, the only tissue-specific biomarker used to diagnose this often diagnosed in advanced stages, our efforts should focus on early diagnosis, validating for example specific

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to his team and encourage his students, postdocs, and PhD students to contact Yamina for potential speaking and Yamina discussed the progress of their research in the GPCR (G protein-coupled receptor) field, specifically Both agreed that one should find work exciting and interesting, as life is too short to spend doing things shared her plans for an upcoming Doctor GPCR Symposium in June, for which Demet is the first confirmed speaker

that negative charges in the CMKLR1 N-terminus are involved in the formation of strong contacts with a specific

Importantly, GPCRs are naturally nanosized, and spontaneously formed nanoaggregates of GPCRs (natural of various types of cells, GPCR ligands can endow nanoparticles with active targeting capacity for specific SIGNIFICANCE: GPCRs as molecular targets for the majority of marketed drugs are naturally nanosized, and even spontaneously

Concentrations of autoantibodies correlates to intensity of neurological disorders including psychomotor speed

significantly in the two datasets, a mutation enrichment in cancer patients was observed among class-specific

harness the power of immunotherapy requires consideration of chemokine gradients within the unique spatial

differentially regulated together with their upstream partners across cancer subtypes and are associated to specific