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70 items found for "Selection pressure"
- GPCR Retreat Registration 2023 | Dr. GPCR Ecosystem
to register for the meeting and submit an abstract for consideration for the trainee symposium and selected
- Observational Study of Repeat Immunoadsorption (RIA) in Post-COVID ME/CFS Patients with Elevated ß2-Adrenergic Receptor Autoantibodies-An Interim Report
The results of this observational study will provide the basis for patient selection for a randomised
- Ep 87 with Dr. Bianca Plouffe
involved in the angiotensin type 2 receptor (AT2R)-mediated neurite outgrowth while characterizing new selective
- Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer
By revealing that small molecules can selectively disable noncanonical mechanisms of G-protein activation
- Ep 152 with Dr Arthur Christopoulos
In 2017, he was elected a Fellow of the Australian Academy of Health and Medical Sciences, in 2018 as a Fellow of the British Pharmacological Society, and in 2021 he was elected a Fellow of the Australian In 2023, he was elected a Fellow of the Pharmaceutical Society of Australia. " Dr. collaboration with Patrick Sexton and Jim Burch, and the discovery of hybrid molecules with functional selectivity
- In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors with Anticancer Activity
identified hits to RGS2 as well as other RGS structures was used to screen the hits for potent and selective
- GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis
0 Subunit) and promotes its association to cargo proteins, such as EGFR, which subsequently enables selective
- Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells
KS-133, a newly developed VIPR2-selective antagonist peptide, attenuated VIP-induced cell proliferation
- Identification of Small-Molecule Antagonists Targeting the Growth Hormone Releasing Hormone Receptor (GHRHR)
Preliminary analysis of the specificity/selectivity of one of the most effective hit compounds indicated
- Ep 113 with Dr. Prasenjit Saha
modulators has gained attention as they have the potential to fine-tune cellular responses with greater selectivity
- Principles of Pharmacology in Drug Discovery II
Recordings will be available < Back to GPCR courses Advanced Methods for the Optimization of Candidate Selection
- Evolutionary diversity of CXCL16-CXCR6: Convergent substitutions and recurrent gene loss in sauropsids
leukocyte adhesion by interacting with cell surface-expressed CXCL16 and plays a key role in G-protein selectivity
- The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis
Methods: A high-throughput screening test was used to select the most synergistic partner of BV from
- Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway
Treatment with KS-133, a VIPR2-selective antagonist peptide, significantly inhibited VIP-induced cell
- Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways
chemotherapy, and could potentially serve as a tool to predict combinatorial efficacy and assist in target selection
- Identification of a G-protein coupled receptor-related gene signature through bioinformatics analysis to construct a risk model for ovarian cancer prognosis
Prognostic GPCRRGs were screened using least absolute shrinkage and selection operator (LASSO) Cox regression
- Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
adrenocorticotropic hormone and cortisol in plasma, as well as changes in sympathetic activity (blood pressure
- Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design
Subsequently, we selected a compound from a library of backbone cyclic peptides generated toward the
- Ep 66 with Dr. Antony A. Boucard Jr
biasing latrophilins’ regulation of cyclic AMP pathways and for determining the magnitude of ligand selectivity
- Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells
costimulation of both muscarinic receptors plus the TCR even led to reduced IL-2 expression, suggesting a selective
- GPCR Retreat 2023 - Part II
He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and
- Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis
Univariant and multivariant Cox regression analyses, as well as least absolute shrinkage and selection
- Trainee Symposium II
GPCR Title: Balancing G Protein Selectivity and Efficacy in the Adenosine A2A Receptor About Louis-Philippe Scott Prosser.
- Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
residues that overlap with pathogenic cancer mutations reported in the COSMIC cancer database were selected
- LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration
Conversely, CXCL12-induced calcium signaling and migration were increased in LPAR1 knockout cells, and LPA1-selective
- Ep 145 with Dr John Janetzko
He discovered the National Chemistry Olympiad and was selected to attend a provincial training camp at This led to his participation in the National Training Program in Quebec City and his selection to represent
- Ep 107 with Dr. Roger Sunahara
Our goal is to develop safer beta2AR-selective ligands for the treatment of asthma and acute rescue therapy
- Ep 154 with Dr Badr Sokrat
challenges scientists, particularly students and researchers, face, such as imposter syndrome, constant pressure