forward to target CKRs especially in cancer, nevertheless, targeting this system is a challenging task due

We'll pause our regular updates during this time and will resume our newsletter in the upcoming year signaling pathways GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage migration during

an E3 ubiquitin ligase adaptor for substrate linear polyubiquitination GPCR Binders, Drugs, and more Dual

Sosei Heptares Announces Submission of New Drug Application in Japan for Daridorexant (ACT-541468), a Dual

For this reason, GPCRs have been a focus of drug development for decades due to their role in regulating

low relatedness Industry News Nobel Laureates Highlight Symposium Celebrating Lefkowitz’s 50 Years at Duke

Development DKK 25 million to development of databases supporting medical research ‘Define your own success’: Duke

selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2 Antipsychotic displays dual Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

in Cardiology, Endocrinology, and Taste Structural and functional analysis of salivary intercalated duct Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

., Dukkipati, A., Feinberg, E. N., Angelini, A., Waghray, D., Dror, R. O., Ploegh, H.

Robert Lefkowitz on his 50 years at Duke. Congratulations. Dr. basis of GPR84 signaling Structural diversity of leukotriene G-protein coupled receptors Industry News Duke Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting

Emerging Cannabinoid Analogs GPCRs in Neuroscience Serotonin signaling regulates actomyosin contractility during

Immunology Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant Neuroimmune interplay during

signaling predominantly occurs at the plasma membrane, certain receptors retain their active conformation during Consequently, understanding dynamic interactions between effectors during trafficking becomes crucial elusive, and certain effector proteins with overlapping sites may experience mutually exclusive binding due M. et al. 1999), while dual knockout is lethal (Schmid, C. L., & Bohn, L. M. 2009).

Randy Hall's study: GPR37L1's role in shaping cortical astrocytes during development Dr. activating GHS-R1a/D2R heterodimers GPR37L1 controls maturation and organization of cortical astrocytes during

Adhesion GPCRs Dual role of the adhesion G-protein coupled receptor ADRGE5/CD97 in glioblastoma invasion

Structural and Molecular Insights into GPCR Function Dual mechanisms of cholesterol-GPCR interactions

adopting a hook-like conformation, whereas the chemokine antagonist ([5P7]CCL5) folds into a helical shape due precise molecular signature responsible for G-protein activation by CCR1 remains unknown, primarily due

Differential Responses of the GLP-1 and GLP-2 Receptors to N-Terminal Modification of a Dual Agonist.

This event extends the duration of β-arrestin at the plasma membrane, enabling it to independently reach

Pharmaceuticals Announces Positive Phase 3 Results Showing Mavorixafor Reduced the Rate, Severity, and Duration

Single-cell transcriptome analysis of NEUROG3+ cells during pancreatic endocrine differentiation with Biotechnology will be participating in a panel discussion at the LSX World Congress Novel living yeast-based dual

However, the selectivity of SNARE complex proteins to regulate the release of different types of GPCRs during

GPR37L1 controls maturation and organization of cortical astrocytes during development.

CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging But why do canonical chemokine receptors have this dual role in physiology? How balanced is this dual role?

hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during

The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary

As negative regulators of GPCR signaling, RGS proteins play a critical role in regulating the duration