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69 items found for "Systemic treatment"
- Ep 121 with Yao Lu (Jackie)
investigating the role of functional selectivity in a novel class of potential antipsychotics for the treatment
- Ep 52 with Dr. Benjamin Myers
with David Julius on the structure, function, and physiology of ion channels and GPCRs in the nervous system
- The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis
an anti-CD30 monoclonal antibody linked to a microtubule-disrupting agent, has been approved for the treatment chidamide and BV were demonstrated in a study of HH-cell xenograft mice; mean tumor size following combined treatment
- Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies
The treatment of GBM is challenging due to the presence of the blood-brain barrier (BBB), which hinders Hence, identifying the crucial pathways and biomarkers for the treatment of GBM is of prime importance
- Ep 85 with Nicholas Holliday
work that led to Nick's interest in peptide messengers regulating appetite, metabolism, and the immune system
- Ep 37 with Dr. Samuel Hoare
science, and academic scientists in the development of new therapeutics and the understanding of receptor systems
- Chemokine Physiology in Cancer
Chemokines are a physiologic system that is finely tuned by ligand and receptor expression, ligand or
- G protein-coupled receptors related to autoimmunity in postural orthostatic tachycardia syndrome
Herein, we review the association of anti-GPCR autoantibodies with disorders of the autonomic nervous system
- Olfactory Receptors and Tumorigenesis: Implications for Diagnosis and Targeted Therapy
and targeted therapy through therapeutic targeting of olfactory receptors as an adjunct anticancer treatment
- Ep 45 with Dr Ralf Jockers
variants are biased and their defects are signaling pathway-specific opening new perspectives for T2D treatment
- The landscape of cancer-rewired GPCR signaling axes
date May 8, 2024 Abstract "We explored the dysregulation of G-protein-coupled receptor (GPCR) ligand systems
- The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer
unconventional Class C GPCR but also hold the potential to advance drug development targeting GPRC5D for the treatment
- The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication
the effect of EBI2 antagonists on the residual viral production persisting in patients aviremic under treatment
- GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer
Genetic mouse models of CRC coupled with Gpr176-deficiency are investigated, and in vivo and in vitro treatments
- From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction
In some model systems, CCN1 and CCN2 play key roles in LPA/S1P-induced cell migration and proliferation
- Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
27, 2023 Abstract "Somatostatin receptors are clinically validated GPCR biomarkers for diagnosis and treatment
- Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia
Mechanistic studies revealed that 8GL treatment inhibits the activation of the mammalian target of rapamycin
- Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney fibroblasts
kidneys of mice with UUO or diabetes or injected with adriamycin or folic acid, whereas renin angiotensin system
- Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice
In this setting, OGR1 KO mice displayed an increased activation of the immune system and a higher production
- S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia
Published date July 1, 2024 Abstract "Imatinib (IM), a breakthrough in chronic myeloid leukemia (CML) treatment
- Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer
lung cancer Published date July 3, 2023 Abstract "Despite campaigns and improvements in detection and treatment
- Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design
involvement of PAR PH binding motif signaling in ovarian cancer and Pc(4-4) as a potential therapy treatment
- Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer progression and therapy
complexities of extracellular ATP (e-ATP) and ADO effects on the TME poses challenges in identifying optimal treatment
- A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages
The treatment with β-hydroxybutyrate increased gene expression of GPR109A, CD86, IL1B and NOS2 in U937
- Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway
Treatment with KS-133, a VIPR2-selective antagonist peptide, significantly inhibited VIP-induced cell
- The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor
physiological functions of many GPCRs and the involvement of them in autoimmune diseases of the central nervous system
- Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells
Clozapine treatment induced high IFN-γ, CD69, and CD25 expression, but surprisingly did not induce substantial
- GPCR Retreat 2023 | Dr. GPCR Ecosystem
scientists working in the arenas of structure and signaling, neuroscience, cancer, translational and model systems
