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kinases – a potential pathway for GPCR-targeted drug discovery Nicola J Smith, Lauren T May, and Natasha L

a peripherally restricted chemogenetic system Hye Jin Kang , Brian E Krumm , Adrien Tassou , Bryan L

January 2022 "G-protein-coupled receptors’ star has been on the rise in biotech in recent years as researchers have discovered the vast potential for GPCR-targeting drugs in treating a range of health conditions, from cancer and genetic disorders to inflammation and metabolic imbalances. Among those hitching their wagons to that star are Verily and Sosei Heptares, which have struck a research agreement to discover new GPCR targets that’ll fuel the development of potential drug candidates. The financial details of the strategic collaboration weren’t released, but Sosei Heptares’ past two team-ups in GPCR-based drug discovery have clocked in at $1 billion—with Genentech—and, just last November, $2.6 billion in a partnership with Neurocrine." Read more at the source #DrGPCR #GPCR #IndustryNews

Sakmar, Debbie L. Hay, Lukas Grätz, and more. Check out some of the latest GPCR discoveries below!

Endogenous l- to d-amino acid residue isomerization modulates selectivity between distinct neuropeptide

June 2022 "June 15, 2022 06:30 AM EDT - In 2016, Abbie Celniker was promoted to partner at Third Rock Ventures as the firm raised just over $600 million for its fourth fund. Since then, Celniker has helped usher in an additional fund and headed a few startups as interim CEO. Coming on its 15th year, Third Rock Ventures announced its sixth fund today — and largest one by far — at a whopping $1.1 billion. Adding it all up, Third Rock has raised $3.8 billion since its inception. That money has gone to some 60 biotechs, much of it as early funding." Read more at the source #DrGPCR #GPCR #IndustryNews

and dopamine D2 receptor is required for selective potentiation of dopamine D2 receptor function by L-

Katharina Grotsch, Bryan L Roth, Valery V Fokin  et al. for their research on Virtual Screening of a

receptor internalization, with the same observations made for CCR2-expressing THP-1 monocytic cell line L. In line, β-Arrestin KO cells showed a major reduction in CCL14 scavenging by CCR1, in contrast with a

L., Stepniewski, T.

Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced

In the skin, OR51E2 was shown to play a role in human melanocyte homeostasis (Gelis L. et. al 2016) and

was performed highlighted a new hydrophobic conserved motif composed of phenylalanine (F)/leucine (L)

Starting from previously reported intracellular CCR2 antagonists, several tetramethylrhodamine (TAMRA

family mediates βarrestin-independent GPCR endocytosis Valeria Robleto , Ya Zhuo , Joseph Crecelius , Sara Direct line to the Dr.

Sara Marsango and Graeme Milligan for their research on the Regulation of the pro-inflammatory G protein-coupled Cardiology, Endocrinology, and Taste The Genetic Pathophysiology and Clinical Management of the TADopathy, X-Linked pathway networks as cancer therapeutic targets Generation of comprehensive GPCR-transducer-deficient cell lines

Prézeau, for their research on Heterodimers revolutionize the field of metabotropic glutamate receptors Kara

GPCR Events to keep you informed and engaged GPCR Jobs connecting candidates with positions Direct line

Exciting event listings to keep you on your toes  Direct line to all the cool cats in the GPCR community

Heterodimerization when Expressed Heterologously in Saccharomyces cerevisiae The beta 2 adrenergic receptor cross-linked intestinal dendritic cells Methods & Updates in GPCR Research Generation of CRISPR/Cas9 modified human iPSC line

Get ready to be blown away by our fantastic lineup of speakers HERE !

In a recent study on TAAR1, a GPCR linked to central nervous system disorders, researchers compared the

breathe new life into schizophrenia pipeline GPCR Dynamics Reveal Mechanisms for Drug Discovery DMS: Linking

They employed a series of phospho-mimicking mutants and assays such as linear ion trap mass spectrometry

BERKY consists of a membrane linker, a BRET donor, an ER/K α-helix linker, a BRET acceptor, and an active

United With or Without an Additional Transmembrane Sequence Indicate Classification into Three Groups of Linkers

Classified GPCR News from April 1st to 7th, 2024 GPCR Activation and Signaling GPRASP1 loss-of-function links

different ligands inducing unique GPCR conformations that selectively activate specific cellular outcomes linked