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135 items found for "Tatiana Da Ros"
- Ep 126 with Dr. Françoise Bachelerie
ACKR3 (CXCR7) receptors of the CXCL12 chemokine, key effectors of the immune system, including their role
- Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration
The roles of histamine and histamine receptor H1 (HRH1) in cancer pathogenesis remain controversial.
- Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer progression and therapy
It plays a critical role in transmitting signals inside the body, which is necessary for controlling
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Mediated in part by highly druggable extracellular proteins, this axis plays essential roles in fibrosis Authors Elena Tomas Bort , Megan Daisy Joseph , Qiaoying Wang , Edward Philip Carter , Nicolas Jaime Roth , Jessica Gibson , Ariana Samadi , Hemant M Kocher , Sabrina Simoncelli , Peter J McCormick , Richard
- Ep 85 with Nicholas Holliday
Since 2019, Nick has combined his university role with the leadership of Excellerate Bioscience as Chief
- Esophageal and gastric cancer incidence trends in Golestan, Iran: An age-period-cohort analysis 2004 to 2018
Sedaghat , Hamideh Sadeghzadeh , Mahnaz Akbari , Mahshid Mehrjerdian , Elisabete Weiderpass , Gholamreza Roshandel
- Ep 142 with Dr Claudia Stäubert
Our ultimate goal is to understand their role in immune cell function and cancer cell metabolism. " Dr Metabolite Activation of GPCRs: A Fascinating Discovery Claudia and Yamina discussed the role of metabolites
- CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration
chemotaxis guided by the G protein-coupled receptor (GPCR) CCR7, we demonstrate that in addition to its role Such a dual role of CCR7 as a GPCR that both senses and consumes its ligand can thus provide a novel
- Ep 133 with Dr. Richard Premont
In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role
- Ep 17 with Dr. Yamina Berchiche
Yamina Berchiche About this episode GPCRs have played a central role in my scientific career ever since
- Ep 136 with Murat Tunaboylu & Ben Holland
After switching to biotech, Murat has built cell imaging software and lab robots to accelerate cancer
- Ep 18 with Dr. Yamina Berchiche
Yamina Berchiche About this episode Listen to this fantastic round table discussion that I had the privilege
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium
Our results suggest that GPR15/GPR15L have a pathogenic role in RA and their antagonizing could be a
- Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq
However, the role of PR in breast cancer is only poorly understood. Conclusions: The present study provides new insights into the complex role of PR in ERα-positive/PR-positive Authors Mariana Bustamante Eduardo , Irene Keller , Nathalie Schuster , Stefan Aebi , Rolf Jaggi Tags
- Ep 71 with Dr. Jean Martin Beaulieu
Beaulieu has pioneered work establishing a role for Beta-arrestin signaling in the brain in vivo and
- Ep 79 with Dr. Graeme Milligan
He was elected to the Fellowship of the Royal Society of Edinburgh in 1998 and to the Fellowship of the
- Ep 134 with Dr. Neil Grimsey
To further define the role of atypical p38 signaling responses we are studying how atypical p38 controls
- CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases
The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local
- Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer
Conclusions: It was suggested that GPR37 acts a crucial role in promoting the occurrence and development
- Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling
Thus, we establish a critical role for efferocyte-derived vesicular mediators in increasing macrophage
- Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure
These observations do not hint towards a specific cardio-pathogenic role of GPCR autoantibodies and suggest Scheiber , Harald Heidecke , Ralf Dechend , Carmen Barthuber , Sina Kaufmann , Malte Kelm , Michael Roden
- "Have a nice weekend, and I'll see you tomorrow!": RAMP-interacting GPCR Pathways
Keith Parker to elucidate the role of steroidogenesis in regulating sexual determination and adrenal Oliver Smithies at UNC-CH, where she was the first to discover the essential role of adrenomedullin peptide Caron currently holds multiple scientific advisory roles in academia, industry and the National Institutes
- G Protein-coupled Receptor-mediated Membrane Targeting of PLCγ2 is Essential for Neutrophil Chemotaxis
mechanism of membrane targeting of PLCγ2 and the signaling pathways by which PLCγ2 plays an essential role
- Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies
MetaCore and gene ontology (GO) analyses were conducted to explore the role of GNAI3 in co-expressed
- G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression
protein-coupled receptors (GPCRs) are essential contributors to tumor growth and metastasis due to their roles Here, we discuss the current understanding of the roles of GPCRs and their signaling pathways in tumor Additionally, we focus on the roles of GPCRs in regulating immune checkpoint proteins involved in immune This expanded understanding of the role of GPCRs may shed light on the mechanisms underlying tumor progression
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis
How signaling emanating from cilia orchestrates tissue organization-especially, the role of cilia-generated We also tested the role of cilia-generated signaling using a Gpr161 ciliary localization knock-in mutant
- Ep 118 with Dr. David Sykes
years of experience working in a drug discovery environment mainly in a specialist assay development role
- Ep 32 with Dr. Chris Tate
Join me to learn more about Chris’s work and his role in founding Heptares which was later acquired by