Search Results
103 items found for "Timo De Groof"
- A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands ...
In a proof-of-principle study, we succeeded in showing that our CCR9-PROTAC is able to reduce CCR9 levels
- G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease..
GPR3-mediated G protein and β-arrestin signaling produce discrete and separable effects and provide proof
- Rescue of Cell Surface Expression and Signaling of Mutant Follicle-Stimulating Hormone Receptors
aid in advancing the understanding of the effects of genetic mutations on GPCR function and provide a proof
- The Perils and Guardrails of Modifying Signalling Proteins in Bioassays
Clinical development times for innovative drugs. Seven transmembrane receptors as nature's prototype allosteric protein: de-emphasizing the geography Protein Eng Des Sel. 2016;29(12):583-594. 47. Crilly SE, Ko W, Weinberg ZY,Puthenveedu MA.
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
., Rodríguez De Fonseca, F., Puente, N., Marsicano, G., & Grandes, P. (2016).
- 📰 GPCR Weekly News, December 11 to 17, 2023
We'll pause our regular updates during this time and will resume our newsletter in the upcoming year Gastric Inhibitory Polypeptide Receptor (GIPR) Revealed by Trapped-Ion-Mobility Spectrometry Coupled to Time-of-Flight Mass Spectrometry (TIMS-TOF MS) A rapid, tag-free way to purify functional GPCRs tANCHOR fast and cost-effective Structure Therapeutics Provides Comprehensive GSBR-1290 Program Update Including Clinically Meaningful Proof-of-Concept
- 📰 GPCR Weekly News, May 8 to 14, 2023
If you're interested in presenting a poster, there's still time. Therapeutics in the 23rd BioEquity Europe Conference Simon Bekker-Jensen and Mette M Rosenkilde received two proof
- 📰 GPCR Weekly News - January 9 to 15, 2023
Industry News Trevena Enrolls First Subject in TRV045 Proof-of-Concept Trial Evaluating S1PR Mechanism
- 📰 GPCR Weekly News, October 16 to 22, 2023
surface protein in yeast cells Trevena Reports Favorable TRV045 Topline Safety and Tolerability Data from Proof-of-Concept
- Regulators of G-protein signaling: essential players in GPCR signaling
in their structural complexity, some members of the RGS family are selective for certain GPCRs, as a proof
- Glyco-sulfo hotspots in the chemokine receptor system
post-translational modifications (PTMs), contribute to the high affinity binding to the positively charged groove
- Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands..
kinetics-based drug development have become immensely interested in predicting the drug target residence time Screening drug candidates in terms of their computationally predicted residence times, which is a measure from steered molecular dynamics simulations and the Bell-Evans model to predict the absolute residence times We have predicted the absolute ligand residence times on the timescale of seconds.
- Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling
Bioluminescence Resonance Energy Transfer (BRET), has revolutionized the study of GPCRs by enabling real-time One of the significant advantages of FRET and BRET-based sensors is their ability to provide real-time discovery efforts by enabling the precise characterization of pharmacological interventions in real time Galés, C., et al., Real-time monitoring of receptor and G-protein interactions in living cells. Eidne, Bioluminescence resonance energy transfer (BRET) for the real-time detection of protein-protein
- 📰 GPCR Weekly News, April 29 to May 5, 2024
If you aren't joining us this time, stay tuned for more Dr. GPCR University content coming soon.
- In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
photometry with FRET-based biosensors, we were able to track GPCR-dependent signaling pathways over time weeks to allow biosensor expression, fiber photometry is used in order to record drug responses in real time
- Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells
In this study, for the first time, we demonstrate the nuclear localization of H2R in lymphatic endothelial At the same time, H2R as a GPCR imparts many unresolved questions, such as the functional relevance of
- Reflections on My PhD Journey: Lessons Learned
generating data when experiments are working smoothly, but neglecting to analyze that data in real-time Procrastination may seem tempting, but tackling your work incrementally will save time and reduce stress
- FSH and bone: Comparison between males with central versus primary hypogonadism
aims to investigate the possible role of FSH excess in male bone health, by comparing for the first time
- ShouTi Introduces Basecamp Bio as a Wholly Owned Subsidiary to Expand Pipeline and Partnerships
March 2022 "February 17, 2022 08:00 AM Eastern Standard Time SAN FRANCISCO & SHANGHAI- ShouTi Inc., a
- Ginsenoside Rg5 allosterically interacts with P2RY12 and ameliorates deep venous thrombosis by...
DVT formation is a time-dependent inflammatory process in which NETosis plays an important role.
- Illuminating the draggable GPCR-ome
This time with none other than Dr. Bryan Roth There are 10 open tickets available. Get yours now!
- Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through...
In rodents, intrathecal injection of its ligand, 7α,25-dihydroxycholesterol (7α,25-OHC), causes time-dependent Non-biased transcriptomic analyses of dorsal-horn spinal cord (DH-SC) tissues harvested at the time of
- Tectonic Therapeutic Strengthens Leadership Team
July 2022 "July 19, 2022 07:00 AM Eastern Daylight Time BOSTON--Tectonic Therapeutic, Inc. a pre-clinical
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell...
Methods: Immunohistochemistry, western blot and quantitative real-time PCR techniques were used to analyze
- GPR110, a receptor for synaptamide, expressed in osteoclasts negatively regulates osteoclastogenesis
In this study, we found, for the first time, that the expression of GPR110 increased during osteoclastogenesis
- Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors
Instead, fast calcium signals in PFC astrocytes are time locked to dopamine release and are mediated
- Design Pharmaceuticals Closes $5 Million Pre-series A Round to Accelerate Commercialization of ...
Commercialization of Ultrahigh Throughput Drug Discovery Platform "April 12, 2022 07:00 AM Eastern Daylight Time
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
fluorescence, electrochemiluminescence, fluorescence emission, immunofluorescence staining, HTRF (homogeneous time-resolved fluorescence), and TR-FRET (time-resolved fluorescence resonance energy transfer).