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64 items found for "Tumor"
- Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies
Invasive procedures alone are not effective at completely removing such tumors. Within this dataset, we observed the association in the tumor microenvironment between the gene expression
- Ep 146 with Dr Michael Feigin
polyadenylation as a targetable driver of pancreatic cancer, and 2) dysregulation of the pancreatic tumor Ricky's group at UPenn to explore the GPCR side of the lab, which led to the discovery of potential tumor had a discussion about their research on GPCRs, specifically focusing on GPR68 and its role in the tumor his team's current focus on alprazolam, an anti-anxiety medication that has unexpected effects in the tumor his experiments and discoveries about GPR161 in mammary epithelial cells, the effect of alprazolam on tumors
- Session IX / Technology capsule: Light on aGPCR signaling and function | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
antibodies for complex targets, with implications for overcoming challenges like drug resistance and tumor
- Targeting adenosine signaling for immuno-oncology
protein-coupled receptors is increasingly recognized as an important immune checkpoint in the generation of anti-tumor
- Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells
highly expressed in many cancer cells, including prostate cancer (PCa), and regulate various aspects of tumor
- High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro
Published date June 26, 2023 Abstract "G protein-coupled receptors (GPCRs) play important roles in tumorigenesis Previous studies have indicated that GPR50 could protect against breast cancer development and decrease tumor
- From odor to oncology: non-canonical odorant receptors in cancer
The roles of these non-canonical chemoreceptors in cancer are complex, with some receptors promoting tumorigenesis and others acting as tumor-suppressing factors upon activation, depending on the cancer type.
- Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer
specifically disrupted their engagement with GIV/Girdin, thereby blocking noncanonical G-protein signaling in tumor
- Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia
Importantly, 8GL alone or in combination with an mTOR inhibitor remarkably impaired tumor growth and
- A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
cytomegalovirus (HCMV) is associated with accelerated progression of glioblastomas, aggressive brain tumors
- Unveiling Non-Canonical Functions for Gαq Signaling Pathways
role of G protein-coupled receptor kinase 2 (GRK2), a known regulator of Gq-GPCR signaling in HNSCC tumor
- GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced lymphomagenesis
Single-cell transcriptome further delineated the tumor microenvironment as immune-inflamed, -deficient
- Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling
In human breast tumor tissue, we show via immunofluorescence that NPY5R protein levels and colocalization
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
We confirmed the elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors
- Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration
widely overexpressed in various types of cancer and is involved in several cancer phenotypes including tumor
- The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor
Such mutations may affect serotonin-mediated signaling in tumor cells as well as treatment strategies
- The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis
The combined effects of chidamide and BV were demonstrated in a study of HH-cell xenograft mice; mean tumor
- Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer
Mechanistically, UCA1 sequesters let-7 miRNAs, effectively neutralizing their tumor-suppressive functions
- SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma
Zihan Quan , Yuting Zhan , Haihua Wang , Jiadi Luo , Weiyuan Wang , Songqing Fan Tags biomarkers , tumor
- Identification of a G-protein coupled receptor-related gene signature through bioinformatics analysis to construct a risk model for ovarian cancer prognosis
prognosis Published date June 18, 2024 Abstract " Background: Ovarian cancer (OV) is a common malignant tumor
- GPCR Retreat 2023 - Part II
Richard Vile's lab at Mayo Clinic where she aided the evaluation of tumor-specific oncolytic viruses.
- Session II | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
His research interest lies in understanding the molecular basis for human tumor development and how to s research examines how genetic alterations and hypoxia induce changes in cell biology that promote tumor
- Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating Ca2+ Flux
interleukin-8 (CXCL8/IL-8) is indispensable for the activation and trafficking of inflammatory mediators and tumor
- Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis
It has been gradually recognized that GPCRs are of significance for tumorigenesis, but in-depth studies The tumor immune dysfunction and exclusion (TIDE) algorithm was utilized to evaluate immune infiltration
- Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
Regulator of G protein signaling protein 6 (RGS6), identified as a tumor suppressor gene, has received
- [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts]
levels of the inflammatory cytokines in GFs induced by LPS, namely, interleukin (IL)-1β, IL-6, IL-8, tumor
- Full Agenda for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Between Extracellular and Transmembrane Regions of a Holo-Adhesion GPCR Virginea de Araujo Farias Anti-Tumorigenic Medulloblastomas Alex Torrelli-Diljohn Investigating The Role of ADGRB3 Loss of Expression in Brain Tumor
- Chemoattractant receptor signaling in humoral immunity
< GPCR News < GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral immunity Published date April 4, 2024 Abstract "Efficient induction of humoral immune responses depends on orchestrated to chemoattractant receptors and plays an important role in the control of B cell migration during humoral review, we summarize the current understanding of chemoattractant receptor signaling in the context of humoral