We showed that CD97 (ADGRE5), in particular, drives tumor growth via effects on GBM stem cell self-renewal patient-derived GBM xenografts in the brain of immunodeficient mice resulted in significant reduction of tumor Collectively, these data suggest that ADCs targeting CD97 impair tumor growth in preclinical GBM models As a clinician, he specializes in surgical treatment of brain tumors.

His research interest lies in understanding the molecular basis for human tumor development and how to s research examines how genetic alterations and hypoxia induce changes in cell biology that promote tumor gaps in knowledge, we used biochemical and cell-biological approaches using cell-lines overexpressing wild-type

polyadenylation as a targetable driver of pancreatic cancer, and 2) dysregulation of the pancreatic tumor Ricky's group at UPenn to explore the GPCR side of the lab, which led to the discovery of potential tumor had a discussion about their research on GPCRs, specifically focusing on GPR68 and its role in the tumor his team's current focus on alprazolam, an anti-anxiety medication that has unexpected effects in the tumor his experiments and discoveries about GPR161 in mammary epithelial cells, the effect of alprazolam on tumors

antibodies for complex targets, with implications for overcoming challenges like drug resistance and tumor

< GPCR News < GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral immunity Published date April 4, 2024 Abstract "Efficient induction of humoral immune responses depends on orchestrated to chemoattractant receptors and plays an important role in the control of B cell migration during humoral review, we summarize the current understanding of chemoattractant receptor signaling in the context of humoral

protein-coupled receptors is increasingly recognized as an important immune checkpoint in the generation of anti-tumor

highly expressed in many cancer cells, including prostate cancer (PCa), and regulate various aspects of tumor

Published date June 26, 2023 Abstract "G protein-coupled receptors (GPCRs) play important roles in tumorigenesis Previous studies have indicated that GPR50 could protect against breast cancer development and decrease tumor

The roles of these non-canonical chemoreceptors in cancer are complex, with some receptors promoting tumorigenesis and others acting as tumor-suppressing factors upon activation, depending on the cancer type.

specifically disrupted their engagement with GIV/Girdin, thereby blocking noncanonical G-protein signaling in tumor

Importantly, 8GL alone or in combination with an mTOR inhibitor remarkably impaired tumor growth and

cytomegalovirus (HCMV) is associated with accelerated progression of glioblastomas, aggressive brain tumors

role of G protein-coupled receptor kinase 2 (GRK2), a known regulator of Gq-GPCR signaling in HNSCC tumor

Single-cell transcriptome further delineated the tumor microenvironment as immune-inflamed, -deficient

In human breast tumor tissue, we show via immunofluorescence that NPY5R protein levels and colocalization

We confirmed the elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors

widely overexpressed in various types of cancer and is involved in several cancer phenotypes including tumor

The combined effects of chidamide and BV were demonstrated in a study of HH-cell xenograft mice; mean tumor

Mechanistically, UCA1 sequesters let-7 miRNAs, effectively neutralizing their tumor-suppressive functions

Zihan Quan , Yuting Zhan , Haihua Wang , Jiadi Luo , Weiyuan Wang , Songqing Fan Tags biomarkers , tumor

prognosis Published date June 18, 2024 Abstract " Background: Ovarian cancer (OV) is a common malignant tumor

Richard Vile's lab at Mayo Clinic where she aided the evaluation of tumor-specific oncolytic viruses.

Generation and characterization of collecting duct specific GPR56 knockout mice Jianxiang Xue Anti-Tumorigenic Planar cell polarity (PCP) proteins contribute to tumour growth and invasion. Jianxiang Xue on the web Zaidman Physiology Lab Anti-Tumorigenic Role of Brain Angiogenesis Inhibitor restrain ß-catenin activity through the formation of a BAI3/MAGI3/ß-catenin complex, reducing their tumorigenic To test this hypothesis, we created WNT-like MB cell lines stably expressing tet-on wild-type BAI3 or

interleukin-8 (CXCL8/IL-8) is indispensable for the activation and trafficking of inflammatory mediators and tumor

It has been gradually recognized that GPCRs are of significance for tumorigenesis, but in-depth studies The tumor immune dysfunction and exclusion (TIDE) algorithm was utilized to evaluate immune infiltration

Regulator of G protein signaling protein 6 (RGS6), identified as a tumor suppressor gene, has received

kidney, we evaluated the urine albumin level in mice devoid of GPR110 gene (GPR110 KO) compared to the wild knock-out of cupidon induces a gain in cell adhesion and cell fusion, resembling the mating behavior of wild-type Cupidon mutants, similar to starved wild-type cells, upregulate various extracellular matrix-related

levels of the inflammatory cytokines in GFs induced by LPS, namely, interleukin (IL)-1β, IL-6, IL-8, tumor