Either GRK2 or HDAC inhibition prevented loss of mouse lung bacterial clearance, but only the combination

Transforming growth factor-β (TGFβ) is essential for alveologenesis and lung repair, and the G protein To understand the role of mesenchymal Gαq/11 in lung development, we generated constitutive (Pdgfrb-Cre suppressed myofibroblast differentiation, altered mesenchymal cell synthetic function, and reduced lung TGFβ2 signalling in mesenchymal cells, which is imperative for normal alveologenesis and maintenance of lung Tags Alveologenesis , Cyclical mechanical stretch , GPCR , Gαq/11 , Lung development , TGFβ .

Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc

Authors Mor Oron-Herman , David Kirmayer , Amelie Lupp , Stefan Schulz , Genady Kostenich , Michel Afargan

formation in human intestinal dendritic cells Published date October 29, 2024 Abstract "The intestinal lumen G-protein-coupled receptors (GPCRs) sense metabolites and can act as key mediators that translate gut luminal human gut organoid coculture system, we show that cDC1s extend their dendrites toward pyruvate on the luminal activation via pyruvate enhances the fundamental function of cDC1 by allowing efficient uptake of gut luminal

Authors Luna Dillemans , Karen Yu , Alexandra De Zutter , Sam Noppen , Mieke Gouwy , Nele Berghmans ,

multimeric complexes larger than dimers in MDA-MB-231 human breast cancer cells and in HCC4006 human lung

Mesothelioma and lung cancer induced by exposure to carcinogenic (e.g., certain asbestos) fibers in humans This theory is reviewed, implications of this theory are discussed in relation to mesothelioma and lung Author Kenneth T Bogen Tags Asbestos , Cytotoxicity , Inflammation , Lung cancer , Mesothelioma , Mutation

CELSR1 is reactivated in luminal-type ductal carcinomas. Notably, our pilot data from luminal-type breast cancer cell lines representative of breast carcinomas specific hypothesis that biased expression of CELSR1 isoforms will predict invasive potential of a luminal tumour invasive mechanism (b) quantify CELSR1 isoform expression (mRNA and protein) within patient luminal