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63 items found for "Yang Hoon Huh"
- CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases
Abstract " The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Chemoattractant receptor signaling in humoral immunity
sites on the receptor C termini, which dictates functional outcomes of β-arrestin-mediated signaling, ranging Kazuhiro Suzuki Tags B cell migration , COMMD3/8 complex , GRK Source Contribute to the GPCR News Coming soon
- High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases
Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein , short chain fatty acids Source Contribute to the GPCR News Coming soon Become a Contributor Classified
- Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
provide useful information in relation to receptor-G protein signal transduction. " Authors Xudong Wang Chris Neale , Soo-Kyung Ki , William A Goddard , Libin Ye Source Contribute to the GPCR News Coming soon
- GprC of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells for nematode hunting
Authors Xiaodi Hu, David S Hoffmann, Mai Wang, Lars Schuhmacher, Maria C Stroe, Birgit Schreckenberger , Marcus Elstner, Reinhard Fischer Source Contribute to the GPCR News Coming soon Become a Contributor
- GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment
Migration of GPR4 overexpressing SK-Mel-28 cells was enhanced in a range of pH 6.5 - pH 7.5 as compared Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro
Authors Weiming Zhao , Lingling Xi , Guoying Yu , Gaiping Wang , Cuifang Chang Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News
- CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration
We further show that these self-generated gradients can sustain the long-range guidance of DCs, adapt Jan Schwarz , Jack Merrin , Edouard Hannezo , Michael Sixt Source Contribute to the GPCR News Coming soon
- miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population
Authors Jijun Chen , Liang Wang , Danhua Ma , He Zhang , Jiayan Fan , Hongyan Gao , Xinyu Xia , Wei Wu , Yuyuan Shi Tags GPCR , GRK6 , OSCC , PKC , miRNA Source Contribute to the GPCR News Coming soon Become
- A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages
Authors Ying Bai , Xin Zhang , Jiawei Zhou , Jianqiang Guo , Yafeng Liu , Chao Liang , Wenyang Wang , Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
A 12-point immunoreactive scoring (IRS) range was used for interpretation of the staining results. Lupp , Stefan Schulz , Genady Kostenich , Michel Afargan Source Contribute to the GPCR News Coming soon
- Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors
Authors Bongers B J , Gorostiola González M , Wang X , van Vlijmen HWT , Jespers W , Gutiérrez-de-Terán Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Principles of Pharmacology in Drug Discovery I
of how pharmacology can greatly extend the ability to predict a candidate's therapeutic value in a range
- GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological processes ranging ADGRG1 , Mesenchymal transition , Pathway , Signaling , TG2 Source Contribute to the GPCR News Coming soon
- NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
Authors Ze Wu , Qiongqiong Jia , Boqun Liu , Lanlan Fang , Peter C K Leung , Jung-Chien Cheng Tags Invasion , MMP-9 , NPFFR2 , Neuropeptide FF , Ovarian cancer Source Contribute to the GPCR News Coming soon Become
- Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans
Authors Xin Wan, Geyu Liang, Dayong Wang Tags Accumulation , C. elegans , CPPDQ , Neurotoxicity Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
Authors Victoria H Wu , Bryan S Yung , Farhoud Faraji , Robert Saddawi-Konefka , Zhiyong Wang , Alexander Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
its potential for therapeutic targeting. " Authors Elena Tomas Bort , Megan Daisy Joseph , Qiaoying Wang Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment
Authors Peng Kong , Xu Wang , Ya-Kun Gao , Dan-Dan Zhang , Xiao-Fu Huang , Yu Song , Wen-Di Zhang , Rui-Juan signaling 5 , Vascular remodeling , Vascular smooth muscle cells Source Contribute to the GPCR News Coming soon
- Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer
Rangasudhagar Radhakrishnan , Revathy Nadhan , Rohini Gomathinayagam , Muralidharan Jayaraman , Mingda Yan Srishti Kashyap , Kar-Ming Fung , Chao Xu , Resham Bhattacharya , Priyabrata Mukherjee , Ciro Isidoro , Yong Sang Song , Danny N Dhanasekaran Tags GPCR , High Grade Serous Ovarian Carcinoma , Let-7 miRNAs , Oncogenic Pathways , Ovarian Cancer , Therapy Resistance , UCA1 , lncRNA Source Contribute to the GPCR News Coming soon
- Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia
Authors Peter J P Croucher , Maya Ridinger , Pamela S Becker , Tara L Lin , Sandra L Silberman , Eunice S Wang , Hypomethylating agents , Onvansertib , PLK1 , Splicing Source Contribute to the GPCR News Coming soon
- G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions
gut microbiota act as ligands for specific human G protein-coupled receptors (GPCRs) and modulate a range interactions , Immune system , Inflammation , Metabolites Source Contribute to the GPCR News Coming soon
- Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone
Authors Hsuan Lung, Kelly L Wentworth, Tania Moody, Ariane Zamarioli, Apsara Ram, Gauri Ganesh, Misun Kang Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways
Authors Xin Miao , Gilbert Koch , Shichen Shen , Xue Wang , Jun Li , Xiaomeng Shen , Jun Qu , Robert gemcitabine , pancreatic cancer , proteomics , trabectedin Source Contribute to the GPCR News Coming soon
- Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning
Authors Chenshen Huang , Fengshuo Zhu , Hao Zhang , Ning Wang , Qi Huang Tags Cancer , Machine learning , Molecular biology Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR
- Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer
Authors Han Liu , Yingjie Zhu , Huikun Niu , Jing Jie , Shucheng Hua , Xiaoxue Bai , Shuai Wang , Lei Song Tags EMT , GPR37 , NSCLC , PI3K/Akt pathway , cisplatin Source Contribute to the GPCR News Coming soon
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis
Authors Sun-Hee Hwang , Kevin Andrew White , Bandarigoda Nipunika Somatilaka , Baolin Wang , Saikat Mukhopadhyay Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
- Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions
Neutrophils lacking all four GRK family members show increased chemotactic migration responses to a wide range Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR
