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146 items found for "Ye K"
- AGPCR 24 Session VII
Mosharov1,2,4, David Sulzer1,2,4, Christoph Kellendonk1,2, and Jonathan A. GPR110 knockout (KO) mice displayed trends for increased anxiety-like behaviors in the elevated plus The y-maze showed a significant sex by genotype interactions with GPR110 KO male mice having increased number of correct alterations and errors, while the GPR110 KO females had fewer correct alterations axonogenesis, and synaptogenesis, as well as altered neuroinflammatory marker expression in GPR110 KO
- AGPCR 24 Session VI
Expression analyses of key enzymes of the glutamate glutamine cycle and the glutamate metabolism indicated /University of Karlsruhe/Institute of Technology (KIT), Germany. His lab is well-known in the research on the cellular function of proteins and their networks related Injection of low-dose ketamine, an antidepressant, can lead to acute (in several hours) and sustained Authors & Affiliations "Groff, Karenna; Donaldson, Hayley; Anderson, Sebastian; Pitti, Kiran; Wang, Shuai
- AGPCR 24 Session V
Authors & Affiliations "Fabian Pohl1, Florian Seufert2, Yin Kwan Chung3, Daniela Volke1, Ralf Hoffmann1 Authors & Affiliations "Garbett, Krassimira, Kordon, Szymon P., Shearer, Tanner, Sando, Richard C.*, Authors & Affiliations "Chung, Yin Kwan2, Pohl, Fabian2, Batebi, Hossein1 Sträter, Norbert3 , Langenhan
- AGPCR 24 Student Flash Presentations
, USA" About Abhishek Kumar Singh "I am a doctoral student in the lab of Prof. We previously demonstrated that kidney-specific Adgrf5/Gpr116 knockout causes luminal membrane accumulation These data demonstrate that Adgrf5 transcript variants are cell-specific in the kidney. Moreover, the complete repertoire of aGPCRs expressed in the kidney is undefined. These results reveal the complete set of aGPCRs expressed in the murine kidney.
- Adhesion GPCR Workshop 2024 Full Agenda
System, Proteomics and Transcriptomics, Receptor Structure, Signaling and Activation Mechanism Abhishek Kumar Singh · Alex Torrelli-Diljohn · Emmanouil Kyrloglou · Vasiliki Karagiannakou · Lara-Sophie Brodmerkel independent activation mechanism in AGPCRs Signe Mathiasen · Demet Araç · Yan Zhang · Andrew Dates · Frank Kwarcinski Van Meir · Pal Kasturi Read More 10:30 AM Coffee Break with lights snacks Read More 11:00 AM Session roles of AGPCRs in the periphery Tobias Langenhan · Anastasia Georgiadi · Douglas Tilley · Hee-Yong Kim
- About Dr. GPCR Podcast | Dr. GPCR Ecosystem
about their career trajectory, discoveries, and how their research contributed to the shared pool of knowledge field through discussions with experts Provide researchers with a different outlet to make their work known Kathleen Caron, Dr. Brian Kobilka, and many other amazing scientists.
- Be Our Guest | Dr. GPCR Ecosystem
about their career trajectory, discoveries, and how their research contributed to the shared pool of knowledge
- Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia
Jinqiancao granules are a traditional Chinese medicine used to treat kidney stones and this medicine Docking results revealed that the GPR35-targeting compounds interacted at the key residues for the agonist-initiated
- Ep 144 with Dr Aurélien Rizk
Gebhard Schertler, he developed methods for kinetic mathematical analysis of GPCR signaling.
- Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration
Authors Chulo Park , Jin-Woo Lee , Kiheon Kim , Dong-Seung Seen , Jae-Yeon Jeong , Won-Ki Huh Source
- PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer
Kruskal-Wallis test, Wilcoxon sign-rank test, logistic regression, Kaplan-Meier method, Cox regression
- Ep 84 with Rosie Dawaliby
Brian Kobilka's lab at Stanford University and the SFMB laboratory at the Université Libre de Bruxelles I developed G.CLIPS biotech's innovative technology as a synthesis of the different knowledge, experiences , and know-how from the different stages of my career.
- Ep 126 with Dr. Françoise Bachelerie
projects are devoted to the activation/function of CXCR4-ACKR3 (CXCR7) receptors of the CXCL12 chemokine, key
- Ep 133 with Dr. Richard Premont
the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout , knock-in and conditional models of mouse physiology and behavior."
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Qiaoying Wang , Edward Philip Carter , Nicolas Jaime Roth , Jessica Gibson , Ariana Samadi , Hemant M Kocher
- Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma
Authors Kangjie Shen , Qiangcheng Wang , Lu Wang , Yang Yang , Min Ren , Yanlin Li , Zixu Gao , Shaoluan
- Ep 85 with Nicholas Holliday
Holliday After an undergraduate degree at the University of Cambridge, Nick carried out his Ph.D. at King 2006, where he is now Associate Professor, establishing a lab focused on G protein-coupled receptor kinetics
- Esophageal and gastric cancer incidence trends in Golestan, Iran: An age-period-cohort analysis 2004 to 2018
Abstract "Golestan province in the northeast of Iran is part of the Asian esophageal cancer belt and is known Authors Fatemeh Ghasemi-Kebria , Shahryar Semnani , Abdolreza Fazel , Arash Etemadi , Taghi Amiriani
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
Functional assays demonstrated that RGS16 promoted the CRC progression, knockdown of RGS16 led to significantly
- Ep 142 with Dr Claudia Stäubert
Yamina expressed interest in learning more about this topic as she realized her lack of knowledge on steps, including researching review articles or articles to gain a higher understanding of what is known
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis
pathway repression by the GPCR GPR161, and the ankyrin repeat protein ANKMY2 that direct cAMP/protein kinase-A We performed genetic epistasis between Gpr161 or Ankmy2 mutants, and Gli2/Gli3 knockouts, Gli3R knock-in and knockout of Smoothened, the hedgehog pathway transducer. We also tested the role of cilia-generated signaling using a Gpr161 ciliary localization knock-in mutant The cAMP signaling-competent non-ciliary Gpr161 knock-in recapitulated Gpr161 loss-of-function tissue
- Ep 118 with Dr. David Sykes
this period David has made a significant contribution to the understanding of agonist/ antagonist GPCR kinetic His current interests include the development of HTS fluorescence-based kinetic binding assays specifically designed to assess the kinetics of unlabelled compounds (and chemical fragments) and the use of purified
- Ep 150 with Dr GPCR Team
Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney She received her undergraduate degree in Biotechnology from KIIT University in India. Further down the track, he aims to apply this knowledge to develop novel chemical treatments for neuronal
- Cannabinoid compounds to augment L-DOPA treatment in Parkinson's Disease
Toronto and has continued working on dopamine transmission and homeostasis and the role of several of key
- GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment
in other cancers, acidification of the tumor microenvironment (= TME, inverse pH-gradient) is a well-known Authors Judith Anthea Stolwijk , Susanne Wallner , Judith Heider , Bernadett Kurz , Lisa Pütz , Stefanie
- Ep 116 with Dr. Shivani Sachdev
Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney She received her undergraduate degree in Biotechnology from KIIT University in India.
- Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody
expression of angiogenesis markers, and G-protein-coupled receptor (GPCR)-mitogen-activated protein kinase Authors Amos Hong Pheng Loh , Min Thura , Abhishek Gupta , Sheng Hui Tan , Kelvin Kam Yew Kuan , Koon Hwee Ang , Khurshid Merchant , Kenneth Tou En Chang , Hui Yi Yon , Yong Chen , Mathew Hern Wang Cheng
- G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions
microbiome-immune-brain interactions Published date October 1, 2023 Abstract "Human-microorganism interactions play a key readout of microbe-microbe-human relationship are of great interest for deeper understanding of the inter-kingdom bacterial metabolites that are currently recognized to bind to GPCRs and are found to activate the known