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34 items found for "Yong Chen"
- Unlock the Future of GPCR Science: Breakthroughs and Courses Await | Sep 2 - Sep 8, 2024
pain and chronic inflammation Developmental exposures to common environmental pollutants result in long-term
- Odorant receptors – a bit of smell for drug discovery
odorant molecules which initiate a neuronal response that drives odorant discrimination and perception (Young non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and migration in long-term
- Glyco-sulfo hotspots in the chemokine receptor system
GSnP-6 displays nanomolar affinity and promising potential for blocking PSGL-1/P-selectin interaction (Wong
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
In general, signaling occurs when agonists engage key microswitch structures located in the TM domain surface area of ligand-receptor interface for these GPCRs makes modulation with small molecule drugs, when This leads to strikingly long in vitro receptor occupancy durations (at least seven days), meaning that
- Ode to GPCRs
involved in "short-term memory", whereas cAMP signaling and new protein synthesis are required for "long-term