However, the receptors that these medicines target have been described as the ‘low-hanging’ fruit, and There are approximately 800 human GPCRs in the superfamily, controlling a broad range of physiological This leads to strikingly long in vitro receptor occupancy durations (at least seven days), meaning that Orion’s receptor antagonist analogs have demonstrated powerful efficacies across a range of animal models

August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide range

G protein-coupled receptors (GPCRs) are crucial receptors that regulate a wide range of physiological

ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range

Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells.

associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging

GPCRs respond to a wide variety of signals that range in size from photons to proteins (Foord et al.,

Research CPGL: Prediction of Compound-Protein Interaction by Integrating Graph Attention Network With Long

Hence, it has wide applicability across a spectrum of neuroscience research, ranging from the study of

2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range

The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.

Modes "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range

., Hong, J.

fragment- and seven lead-like compounds were confirmed to bind to the allosteric site with affinities ranging

diseases, (d) showed spontaneously fluctuating Ca levels from approximately normal to near fatally high ranges

fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range

pain and chronic inflammation Developmental exposures to common environmental pollutants result in long-term

fragment- and seven lead-like compounds were confirmed to bind to the allosteric site with affinities ranging

interaction follows a common pattern which is generally described by the classic “two-site” model (Crump, Gong activation will pave the way for significant advancements in the development of therapeutics for a wide range

Nevertheless, the GloSensor™ cAMP assay can be applied to analyze signaling by a wide range of GPCRs

and NAMs and thereby blocks the effects of positive and negative allosteric modulators (Rodriguez, Nong

Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled

Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities

GPCRs are present in a range of conformations, and the binding of a ligand, as well as interactions with desensitization), the same drug acting on the same receptor in the same cellular context can produce a range

odorant molecules which initiate a neuronal response that drives odorant discrimination and perception (Young non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and migration in long-term

Coupled with their ability to respond to a highly diverse range of chemical stimuli, they represent the

Structurally they characterize by a long extracellular region of adhesion-like domains which modulate Qian, Y., Ma, Z., Liu, C., Li, X., Zhu, X., Wang, N., Xu, Z., Xia, R., Liang, J., Duan, Y., Yin, H.,

Chemical communication controls a wide range of behaviors via conserved signaling networks.