Moreover, exendin-P5 has been observed to reduce adipose tissue size more effectively than exendin, suggesting

and Immunology Emerging GPCR targets for AUD: Insights from preclinical studies CB2 stimulation of adipose

guides GPCR binding to arrestin Dietary dibutyryl cAMP supplementation regulates the fat deposition in adipose

dopamine receptor D3 from in silico submolecular analyses GPCRs in Cardiology, Endocrinology, and Taste Adipose

The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation However, an imbalance in the chemokine system can also contribute to various diseases, such as inflammatory of leukocytes throughout the body, ensuring a functional immune system and an effective response to inflammatory Scavenging allows cells to continuously migrate by remaining responsive to chemokines, it dampens the inflammatory Interestingly, in monocytes and dendritic cells exposed to treatments mimicking inflammation, CCR1, CCR2

immune responses in different physiologic and pathologic states such as tissue repair, infection, and inflammation

GPCR-targeting drugs in treating a range of health conditions, from cancer and genetic disorders to inflammation

NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists "In order to avoid a prolonged pro-inflammatory formyl peptide receptor 2 (FPR2), receptors expressed in neutrophils, play a key role in regulating inflammation

It has been discovered in recent years that inflammatory responses are particularly important in subacute However, the mechanisms mediating inflammation are not completely clear.

inhibitors, as these receptors primarily induce the chemotaxis of leukocytes, especially neutrophils, during inflammation results, testing CXCR1/2 inhibitors in clinical trials could be of a great importance to limit the inflammatory

inhibitors, as these receptors primarily induce the chemotaxis of leukocytes, especially neutrophils, during inflammation results, testing CXCR1/2 inhibitors in clinical trials could be of a great importance to limit the inflammatory

In CD8 + T cells, the chemokines promote unique transcriptional responses predicted to regulate inflammatory In a mouse model of contact hypersensitivity, β-arrestin-biased CXCR3-mediated inflammation is dependent

chemokine receptor 2 (CCR2), a class A GPCR that has been pursued as a drug target in oncology and inflammation

investigated this issue in living cells for the CC chemokine receptor 5 (CCR5), a major receptor in inflammation

A2A adenosine receptor (A2AAR) have been considered promising agents to treat Parkinson's disease, inflammation

Exscientia ’s novel bispecific small molecule candidate capable of targeting two distinct targets in inflammation

Pharmacology Laboratory team who are investigating new ways to tackle the disease-inducing chronic inflammation

epithelium playing a pivotal role in removal of toxins and efflux of endocannabinoids to prevent excessive inflammation

September 2022 "Systemic sclerosis (SSc) is a systemic autoimmune disease with the key features of inflammation

chemokine receptors in monocytes and macrophages indicates their involvement in immune cell trafficking and inflammatory chemokine receptors in monocytes and macrophages suggest that these GPCRs could be targeted to modulate inflammatory responses, offering potential therapeutic avenues for conditions such as autoimmune diseases and chronic inflammation

and pathological processes, including body temperature, cardiovascular homeostasis, reproduction, and inflammation

malperfusion, oxidative stress, endoplasmic reticulum stress, dysregulated immune tolerance, vascular inflammation

and the AMPK and TOR pathways, and those that alter oxidative homeostasis and severe and/or chronic inflammation

Currently, a controversy exists as to whether cGAS/STING activation exacerbates inflammation and tissue

Sara Marsango and Graeme Milligan for their research on the Regulation of the pro-inflammatory G protein-coupled insights into biological control GPR84 in physiology-Many functions in many tissues Regulation of the pro-inflammatory fibrotic bone The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation discovery of G protein-coupled receptor-targeting biologics Lipid mediators in neutrophil biology: inflammation

Highly Dynamic during Collagen-Induced Arthritis "The sympathetic nervous system (SNS) has either a pro-inflammatory or anti-inflammatory effect, depending on the stage of arthritis. The change of β2-ADR expression and signaling during sustained inflammation might be an integral part of the switch from pro- to anti-inflammatory action of sympathetic mechanisms in late arthritis."

Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37

mediates desensitization and internalization of G protein-coupled receptors (GPCRs) and it participates in inflammatory ATF6-CHOP apoptosis signaling is involved in the pathogenesis of pSS and that β-arrestin2 encourages inflammation-induced