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251 items found for "drug repurposing"

  • Ep 151 with Dr GPCR Board

    interested in using G-Protein Coupled Receptors (GPCRs) that control virtually everything in the body as drug GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the idea to a thriving Biotech focusing on Systems Biology & AI to accelerate the quest for novel & safer drugs is important for increasing the fundamental knowledge of GPCR biology and for the identification of drug targets and future drug development.

  • Ep 113 with Dr. Prasenjit Saha

    would be a significant breakthrough in cardiovascular biology as they could be targeted for therapeutic purposes Traditional drug discovery efforts have focused on agonists and antagonists that bind to the orthosteric ubiquitous class of plasma membrane receptors and serve as targets for more than one-third of all prescribed drugs

  • Dr. GPCR Summit 2021 Live Talks

    Streicher September 13, 2021 at 9:00:00 PM Learn More >> Through the Looking-Glass: Structure-Based Drug Sato September 14, 2021 at 7:00:00 PM Learn More >> Advancing GPCR drug discovery with bioSensAll® platform 2021 at 8:00:00 PM Learn More >> The challenges of targeting RXFP1, the receptor for the heart failure drug PM Learn More >> Innate Proximity: Utilizing the Inherent Physicality of Receptor Interactions for Drug Demet Araç September 17, 2021 at 6:00:00 PM Learn More >> Structure-guided drug discovery Dr.

  • Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML

    hCCR3), a G protein-coupled receptor (GPCR) expressed predominantly on eosinophils, is an important drug This research could potentially offer new insights into the mechanisms of action of chemokines and drug Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer

    receptors (GPCRs) is a quintessential mechanism of cell signaling widely targeted by clinically approved drugs Tags G protein , GPCR , cancer , drug discovery . Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • Ep 99 with Yamina Berchihce

    interested in using G-Protein Coupled Receptors (GPCRs) that control virtually everything in the body as drug GPCR is to accelerate GPCR drug discovery by sharing the latest research and technology advances in the

  • Ep 58 with Dr. Juan José Fung

    Juan José Fung is a Principal Scientist at GPCR Therapeutics, Inc , a drug discovery company focused spent significant time in the industry studying membrane proteins, antibodies, and HTS methods for drug

  • Ep 54 with Dr. JoAnn Trejo

    is important for increasing the fundamental knowledge of GPCR biology and for the identification of drug targets and future drug development. which has important functions in hemostasis, thrombosis, inflammation, and cancer and is an important drug

  • GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression

    Although G protein-coupled receptors (GPCRs) are among the targets of current antifibrotic drugs, no drug has yet been approved to stop fibrosis progression. Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis

    T-cell lymphoma cells through the enhancement of apoptosis Published date November 3, 2023 Abstract " Purpose high-throughput screening test was used to select the most synergistic partner of BV from 14 candidate drugs Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • Ep 19 with Dr. Fiona Marshall

    As a co-founder of Heptares Therapeutics , now called Sosei Heptares , a GPCR-focused drug discovery and her team made considerable breakthroughs in the field of GPCR stabilization and structure-based drug

  • Ep 38 with Dr. Alexander S. Hauser

    During his Ph.D. with David Gloriam at the Department of Drug Design and Pharmacology in Copenhagen, of Molecular Biology in Cambridge, UK, where he was working on the impact of genetic variations on drug

  • Ep 60 with Dr. Josephine (Pina) Cardarelli

    Cardarelli is a drug development leader with extensive experience driving drug discovery teams in bringing She has extensive experience working with Biologics, and Antibody Drug Conjugates as well as experience

  • Emerging GPCR targets for AUD: Insights from preclinical studies

    Currently, many drugs available on the market act via GPCRs and these receptors remain attractive targets Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • Ep 80 with Dr. Andrew Tobin

    the University of Glasgow, his primary research interests are focused on the rational design of novel drugs staff supported by basic research grants investigating aspects of disease biology and the action of drugs

  • Ep 61 with About Dr. Marta Filizola

    into the structure, dynamics, and function of important classes of membrane proteins and prominent drug To this end, her lab uses several computational structural biology tools and rational drug design approaches

  • Ep 74 with Dr. Daniel Wacker

    established GPCR structural biology and learned the ins and outs of molecular pharmacology and in vitro drug Icahn School of Medicine at Mount Sinai in NYC, where I have been working on structure-function and drug

  • G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression

    Finally, we review the progress of clinical trials of GPCR-targeted drugs for cancer treatment, which Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • Ep 136 with Murat Tunaboylu & Ben Holland

    His current focus is to realise Antiverse’s mission: engineering the future of drug discovery." Murat Tunaboylu on the web Antiverse DSV Future of Drug Discovery Podcast Twist Bioscience LinkedIn Twitter

  • Ep 33 with Dr. David E. Gloriam

    Receptor Biology at the University of Copenhagen where he leads a research cluster for GPCR function and drug one of the coordinators of recommendations to describe ligand bias towards signaling probes and safer drugs

  • G protein coupled receptor transcripts in human immune cells and platelets

    We believe our data should stimulate studies of receptor function and contribute to drug development. Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • Illuminating Functional Selectivity and Allosterism at GPCRs.

    receptors involved in many, if not all, physiological responses, with the ultimate goal of improving drug in-cellulo measurement of protein-protein interactions, receptor trafficking and signalling, useful for drug

  • Role and recent progress of P2Y12 receptor in cancer development

    cancer cells, promote tumor angiogenesis, and affect the tumor immune microenvironment (TIME) and tumor drug Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer

    In the past, studies predicting therapeutic drug targets for cancer therapy focused on the assumption Therefore, there is always an immense need to find promising and novel anti-cancer drug targets. Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway

    date March 2, 2024 Abstract " Background: Novel therapeutic targets are urgently needed for treating drug-resistant non-small cell lung cancer (NSCLC) and overcoming drug resistance to molecular-targeted therapies. Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases

    To date, there are no drugs against CCR6 approved, and the development of small molecules against CCR6 Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer

    distinctive dimer organization of this unconventional Class C GPCR but also hold the potential to advance drug Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs

  • Ep 144 with Dr Aurélien Rizk

    Aurélien Rizk is a scientist and entrepreneur in drug discovery. Before focusing on the development of innovative mathematical modeling and simulation methods for drug Interdisciplinary Teamwork and Drug Development Yamina Berchiche and Aurelien Rizk emphasized the significance of interdisciplinary teamwork in drug and technology development, noting the challenges of communication Aurelien Rizk confirmed his attendance at the upcoming GPCR-Targeted Drug Discovery Summit in Boston.

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