the Receptor Biology Lab, focuses on the development of novel GPCR-based therapeutics that interdict diseases basis of a new technology-based start-up company, HeptOME , to help screen and develop novel longevity/disease-regulating compounds with multidimensional disease efficacy profiles.

the co-founder of both Caldan Therapeutics (2015) which discovers novel therapeutics for metabolic diseases Type 2 Diabetes and other indications including non-alcoholic steatohepatitis (NASH) and inflammatory diseases

While GPR4 deficiency did not show major alterations in disease progression, OGR1 KO mice had higher setting of oxalate-induced nephropathy, the lack of the proton-activated GPCR GPR4 does not influence disease Wagner , Pedro Henrique Imenez Silva Tags G-protein-coupled receptors , acid-base , chronic kidney disease

curated the major advances in understanding GPCR biology and moving closer to targeting receptors in diseases

research laboratory of around 15 staff supported by basic research grants investigating aspects of disease biology and the action of drugs in the context of disease.

of studying metabolites and their receptors, the relationship between metabolites, gut health, and disease They briefly touched upon the link between GPCRs and diseases, such as diabetes, but did not delve into Metabolites, Gut Health, and Disease Progression Yamina and Claudia had a discussion about the relationship between metabolites, gut health, and disease progression. Both agreed on the complexity of the topic, with Claudia concluding that diseases might first affect

parathyroid glands of patients with hyperparathyroidism and their impact on body calcium homeostasis and bone

and pharmacology aiming to understand the role of WNT/Frizzled signaling in biology, physiology, and disease find, create and optimize Frizzled-targeting small molecule drugs to improve future therapies of human disease

, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular disease They highlighted the importance of fine-tuning the approach to suit different diseases and interdisciplinary The discussion also emphasized the need for a disease-specific approach, considering the clinical context Arthur and Yamina discussed the potential of autoantibodies and allosteric modulation in the context of disease

His clinical focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center

the investigation of the regulation of G protein-coupled receptors signaling mechanisms in health and disease investigating the role of metabotropic glutamate receptor signaling in Huntington’s and Alzheimer’s disease

and obtained a PhD in Molecular Medicine and a Clinical Specialisation in Endocrinology and Metabolic Disease protein-coupled receptor (GPCR) signalling and their alterations in endocrine, metabolic and cardiovascular diseases

laboratory has gained valuable insights into the genetic basis and pathophysiology of lymphatic vascular disease , preeclampsia and sex-dependent cardiovascular disease.

during prolonged cold exposure Anastasia Georgiadi ADGRF5-mediated regulation of cardiac health and disease Netherlands; 2Department of Experimental Immunology, Amsterdam institute for Immunology and Infectious diseases Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 3. Georgiadi on the web Endocrine Pharmacology Google Scholar ADGRF5-mediated regulation of cardiac health and disease

gained experience in the identification and characterization of llama-derived antibodies in inflammatory diseases conformations, while also focusing on their therapeutic potential in oncology and transplant infectious disease

In particular, the association of the disease with several types of anti-G protein-coupled receptor ( To date, POTS is recognized as one of the sequelae of coronavirus disease 2019 (COVID-19) and its frequency

the investigation of the regulation of G protein-coupled receptors signaling mechanisms in health and disease investigating the role of metabotropic glutamate receptor signaling in Huntington’s and Alzheimer’s disease

intestinal stem cells to exacerbate colitis Published date May 21, 2024 Abstract "Inflammatory bowel disease Wang , Xinyang Song , Shu Zhu , Wen Pan Tags Enterococcus , IBD , ISCs , colitis , inflammatory bowel disease

laboratory has gained valuable insights into the genetic basis and pathophysiology of lymphatic vascular disease , preeclampsia and sex-dependent cardiovascular disease.

However, the underlying mechanism of virus-cancer immunological interaction during disease pathogenesis comprehensive proteogenomic characterization of natural killer/T-cell lymphoma (NKTCL), a representative disease

elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors exhibited decreased disease-specific survival (DSS) and disease-free survival (DFS) compared to those with low RGS16 expression.

This axis is linked to diseases like HIV/SIV, cancer, and COVID-19. CXCR6 in chickens may have altered CD8 TRM cell abundance, with implications for immunity against viral diseases

directed migration (also referred to as chemotaxis) is a common pathogenic mechanism of inflammatory diseases have implications for therapeutically targeting TIPE proteins in human inflammatory and autoimmune diseases

Much of his work is based on GPCR signaling in the context to cardiovascular diseases.

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the identification of drugs targeting the unique aGPCR receptor family and customize the method for disease-relevant recruited by Vertex Pharmaceuticals (Canada) where he worked on biomarker discovery for inflammatory bowel disease and small molecules drug discovery for polycystic kidney disease. novel pharmacological targets and contribute to the development of innovative treatments for a range of diseases

September 14, 2021 at 2:00:00 PM Learn More >> GPCRomics: Identifying novel GPCR targets in health and disease human GPCR to create self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease More >> Phosphorylation of the M1 muscarinic acetylcholine receptor protects from neurodegenerative disease

in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases She is currently working to understand the signaling and degradation of GPCRs in disease states to help