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186 items found for "high grade serous ovarian cancer"

  • 📰 GPCR Weekly News, June 17 to 23, 2024

    GPCRs in Oncology and Immunology Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer cancer cells by targeting PAR-1 G protein-coupled receptors related to autoimmunity in postural orthostatic cancer prognosis GprC of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells for nematode hunting Role and recent progress of P2Y12 receptor in cancer development immunotherapy: a Society for Immunotherapy of Cancer (SITC) strategic vision Structural and Molecular

  • An overview of the compartmentalized GPCR Signaling: Relevance and Implications

    can influence transcriptional responses and contribute to physiological processes such as meiosis in ovarian For instance, aberrant endosomal signaling by GPCRs has been linked to disorders such as cancer, neurodegenerative Additionally, the conditions within endosomes, such as low pH and high protease activity, can degrade Persistent cAMP Signaling by Internalized LH Receptors in Ovarian Follicles. GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic

  • 📰 GPCR Weekly News, July 10 to 16, 2023

    GPCRs in Oncology and Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates Colorectal cancer incidence trends in Golestan, Iran: An age-period-cohort analysis 2004-2018.

  • 📰 GPCR Weekly News, August 14 to 20, 2023

    Vladimir Katanaev and colleagues identified compromised GPCR signaling in cancer cells using improved MRGPRX1 Improved approaches to channel capacity estimation discover compromised GPCR signaling in diverse cancer ADGRF1) activation PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling Therapeutics' latest science paper was published by the American College of Clinical Pharmacology Sosei and Cancer

  • 📰 GPCR Weekly News, August 28 to September 3, 2023

    inside and back again: the lysophosphatidic acid-CCN axis in signal transduction NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling CCR7 acts as both a sensor and a sink Reveals Insights into the Energy Landscape of the Molecule Focused classifications and refinements in high-resolution

  • 📰 GPCR Weekly News, July 17 to July 23, 2023

    A corazonin G protein-coupled receptor gene in the tick Ixodes scapularis yields two splice variants, Industry News Exscientia Initiates Prospective Observational Study in Ovarian Cancer. Undrugged GPCR Target in Four Months Cumulus Oncology and Leadxpro collaborate on small molecules targeting cancer-focused

  • Regulators of G-protein signaling: essential players in GPCR signaling

    has been implicated in a range of diseases, including cardiovascular disease, pain, hypertension, and cancer While in cancer, RGS proteins are involved in regulating cell proliferation and survival[8]. Y., et al., Identification of a five-gene signature of the RGS gene family with prognostic value in ovarian cancer.

  • Dr. GPCR University registration is now open! Secure your spot now!

    remodeling GPCRs in Oncology and Immunology Unveiling G-protein coupled receptors as potential targets for ovarian cancer nanomedicines: from RNA sequencing data analysis to in vitro validation Signaling by Neutrophil

  • 📰 GPCR Weekly News, November 6 to November 12, 2023

    autistic-like behavior Acetate mitigates cardiac mitochondrial dysfunction in experimental model of polycystic ovarian lipid second messenger signaling Methods & Updates in GPCR Research An image-based abplex method for high-throughput

  • SYnAbs is now officially accredited as a Research Tax Credit by the French Ministry of Higher...

    #technology #lifescience #immunology #antibodies #medicine #cancer #innovation #gpcr #synabs #monoclonalantibodies

  • 📰 GPCR Weekly News, April 15 to 21, 2024

    Immunology Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer Methods & Updates in GPCR Research Alared: Solvatochromic and Fluorogenic Red Amino Acid for

  • 📰 GPCR Weekly News, January 22 to 28, 2024

    parahaemolyticus Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design Structural and Molecular Insights into GPCR Function

  • G.CLIPS biotech is 2 years old this month!

    So very grateful to the great hard working team we have and all the great achievements we have done together Looking forward for more 🎊 #team #grateful #biotech #work #birthdaycelebration" Read more at the source

  • Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...

    macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer It has begun to play important roles in drug development for complex diseases such as cancer, including triple-negative breast cancer (TNBC). incorporated the dynamics of TAMs into our previously published QSP model to investigate their impact on cancer Despite its high mechanistic complexity, the modularized QSP platform can be readily reproduced, expanded

  • Hop in the Time Machine with GPCR: Unraveling the Future of Research! ⦿ Nov 24 - Dec 1, 2024

    the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies High-affinity new GPCR-associated biomarkers for preeclampsia Metabolic control of Luteinizing Hormone-responsive ovarian

  • Decoding β-Arrestins: from Structure to function

    expression data in healthy tissues from the Genotype-Tissue Expression (GTEx) database with data from cancer samples in The Cancer Genome Atlas (TCGA) through the Gene Expression Profiling Interactive Analysis (GEPIA) tool, it is evident that β-arrestin expression is dysregulated in many cancer types. In certain cancer types, only one β-arrestin isoform's expression may be altered, while the other remains downstream signaling complexes, contributing to the complex landscape of cancer-related signaling pathways

  • 📰 GPCR Weekly News, June 24 to 30, 2024

    ADGRB1/BAI1) Generated from an Alternative Promoter in Intron 17 The adhesion-GPCR ADGRF5 fuels breast cancer site-selective activation of mTOR GPCR Binders, Drugs, and more Molecular glues as potential GPCR therapeutics A high-affinity in Oncology and Immunology Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer progression and therapy Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer Distinct Activation Mechanisms of CXCR4

  • 📰 GPCR Weekly News, June 26 to July 2, 2023

    High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1 Esophageal and gastric cancer incidence trends in Golestan, Iran: An age-period-cohort analysis 2004 Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells. Multi-omics integration analysis of GPCRs in pan-cancer to uncover inter-omics relationships and potential

  • Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery

    In various pathological conditions, including cancer, aberrant ERK activity can lead to uncontrolled Recently, several high-throughput screening (HTS) assays for ERK activation have been developed, each ERK: a double-edged sword in cancer. ERK-dependent apoptosis as a potential therapeutic strategy for cancer. Cells, 10(10), 2509.

  • 🤯Mind-blowing GPCR Scoops! Discover the Latest Breakthroughs! ⦿ Nov 18 - 24, 2024

    High-affinity agonists reveal recognition motifs for the MRGPRD GPCR Chunyu Wang ,  Yongfeng Liu ,  Marion only Premium Members will have access to Classified GPCR News to ensure community sustainability and high-quality First Patient in Phase 1/2 Clinical Study of GPR65 Inhibitor PTT-4256 in Patients with Advanced Solid Cancers Signaling Beyond the classic GPCR: unraveling the role of GPR155 role in cholesterol sensing and signaling High-affinity

  • 📰 GPCR Weekly News, August 7 to 13, 2023

    in autism spectrum disorders GPCRs in Oncology and Immunology Molecular characterization of breast cancer 2023 Half Year And Second Quarter Financial Results And Provides Corporate Update Sosei Heptares and Cancer Research UK Announce the Dosing of the First Patient in a Phase I/IIa Trial with Cancer Immunotherapy acquire Inversago Pharma to develop new therapies for people living with obesity, diabetes and other serious

  • 📰 GPCR Weekly News, November 13 to 19, 2023

    GPCRs in Cardiology, Endocrinology, and Taste Transcriptomic changes in glomeruli in response to a high of glioblastoma Methods & Updates in GPCR Research Optogenetic Microwell Array Screening System: A High-Throughput expression tag to enhance GPCR production in E. coli-based cell-free and whole cell expression systems A high-throughput TRUQAP™ (capivasertib) plus fulvestrant approved in the US for patients with advanced HR-positive breast cancer

  • 📰 GPCR Weekly News, April 24 to 30, 2023

    Adhesion GPCRs Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed-atomic Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer. BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer Genetic variants of G-protein coupled receptors associated with pubertal disorders. RGS proteins and their roles in cancer: friend or foe?.

  • Unlocking the Therapeutic Potential of Previously Undruggable GPCRs

    with the receptor at structurally distant sites in the binding pocket, it is difficult to achieve a high GPCRs, but discovery is challenging and the attrition rate during clinical development has been very high for a number of inflammatory diseases including atherosclerosis, scleroderma, multiple sclerosis and cancer and efficiently advance a diversified portfolio of GPCR-targeted drug candidates for the treatment of cancer doi.org/10.1016/j.pep.2015.10.011 · Demonstration of the feasibility of manufacturing clinical grade

  • Transformative GPCR Insights: Unleash New Horizons in Science | Sep 9 - 15, 2024

    Should Enroll Now: Cost-effective & Distinctive Educational Experience Affordable courses that maintain high-quality novel proteins for biology and health research Innovate UK announced the winners of its Transforming Cancer Therapeutics grant, which focuses on developing life-changing cancer treatments. power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer

  • GPCR News Flash! Top Updates You Can't-Miss! + University CheatSheet is finally available! ❄ Dec 2 - 8, 2024

    Insomnia Patient in its Phase 3 Clinical Trial of Daridorexant in South Korea Septerna Touches New High reveal regulators of behavior and learning GPCRs in Oncology and Immunology Short-chain fatty acids and cancer The path of GPR87: from a P2Y-like receptor to its role in cancer progression Ascitic Shear Stress Activates

  • 📰 GPCR Weekly News, July 3 to 9, 2023

    Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer Research Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based high-throughput

  • Harnessing Deep Mutational Scanning for Enhanced Drug Discovery

    mutational scanning (DMS) is a powerful method for studying the functional consequences of various genetic variants This technique combines high-throughput DNA sequencing with systematic mutagenesis to create and assess This high-resolution mapping can confirm the protein’s role in disease pathology and highlight allosteric significant challenge in drug development, particularly in the treatment of infectious diseases and cancer Measuring the activity of protein variants on a large scale using deep mutational scanning.

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