Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory and conjecture a rationale for developing ITA-based therapeutics to treat inflammatory diseases and cancer Authors Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory

However, the role of β2-AR in oral cancer is not well identified. Results: Out of the total of 65 OSCC tissues, 41 tissues (63.1%) exhibited high expression for β2-AR High β2-AR protein expression was significantly associated with multiple risk habits (p = 0.045), histological Kumar Mohanty, Rajender Singh, Vijay Kumar, Uma Shankar Singh, Rakesh Kumar Singh Tags GPCR; OSCC; Oral cancer

< GPCR News < GPCRs in Oncology and Immunology Role and recent progress of P2Y12 receptor in cancer development P2Y12R activation can promote platelet aggregation and adhesion to cancer cells, promote tumor angiogenesis immune microenvironment (TIME) and tumor drug resistance, which is conducive to the progression of cancers cancer. However, a new study suggests that long-term use of P2Y12R inhibitors may increase the risk of cancer

Scientist at GPCR Therapeutics, Inc , a drug discovery company focused on targeting GPCR heteromers in cancer Kobilka’s lab contributing to the elucidation of high-resolution structures of various GPCRs. Dr.

of melanoma cells in the tumor microenvironment Published date December 23, 2022 Abstract Due to its high metastatic potential, malignant melanoma is one of the deadliest skin cancers. In melanoma as well as in other cancers, acidification of the tumor microenvironment (= TME, inverse

< GPCR News < GPCRs in Oncology and Immunology Phase 1/2 study of sorafenib added to cladribine, high-dose

Patients' data on HCC were sourced from the Liver Hepatocellular Carcinoma-Japan (LIRI-JP) and The Cancer dysfunction and exclusion (TIDE) algorithm was utilized to evaluate immune infiltration levels and genetic variations immunotherapy and common antitumor drugs was predicted via the database Genomics of Drug Sensitivity in Cancer In addition, patients were classified into groups with high and low risks. Patients in the high-risk group exhibited a worse prognosis but demonstrated a more favorable immunotherapy

coupled receptors (GPCRs) in breast cancer, and his interest in pancreatic cancer. as a potential drug target due to its high expression in triple negative breast cancer. Mike then transitioned to pancreatic cancer, questioning why genes are dysregulated in cancer, which led him to explore different aspects of gene regulation and its relation to cancer progression. fibroblasts and is crucial for their function, leading to complications in cancer patients.

NovoiSMART technology, utilizing mRNA-based immunization, which can overcome these obstacles by producing high-quality His research experience includes phylogenetics and cancer epigenetics.

GPCR News < GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer macrophages Published date May 28, 2023 Abstract "Adenosine 2a receptor (A2aR), a typical GPCR with a high

GPCR News < GPCRs in Oncology and Immunology From odor to oncology: non-canonical odorant receptors in cancer sensory perception, emerging evidence suggests a compelling interplay between odorant receptors and cancer types, suggesting their contributions to cancer progression. The roles of these non-canonical chemoreceptors in cancer are complex, with some receptors promoting tumorigenesis and others acting as tumor-suppressing factors upon activation, depending on the cancer

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule G Proteins and GPCRs in Cancer Department of Pharmacology, School of Medicine, and Associate Director for Basic Science at the Moores Cancer treatments, and to identify novel multimodal strategies to enhance the response to cancer immunotherapies Silvio Gutkind on the web Gutkind Lab – UC San Diego Moores Cancer Center Gutkind Lab publications Pubmed LinkedIn Twitter UCSD Moores Cancer Center Dr.

Mid-career, he has worked in finance and developed high-frequency trading systems. After switching to biotech, Murat has built cell imaging software and lab robots to accelerate cancer

and Immunology Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer integral membrane proteins that have gained considerable attention as drug targets, particularly in cancer Gnetum gnemon (GG) for the development of of pharmaceuticals targeting GPCRs within the context of cancer We retrieved targets for GG-derived compounds and GPCRs-related cancer from databases. Survival analysis established the clinical prognostic relevance of identified hub genes in cancer.

< GPCR News < GPCRs in Oncology and Immunology Ultrasensitive dose-response for asbestos cancer risk is expected for damage that accumulates in proportion to dose, as hypothesized for increased risk of cancer relation to genotoxic dose according to the multistage somatic mutation/clonal-expansion theory of cancer Mesothelioma and lung cancer induced by exposure to carcinogenic (e.g., certain asbestos) fibers in humans A recent Inflammation Somatic Mutation (ISM) theory of cancer posits instead that tissue-damage-associated

< GPCR News < GPCRs in Oncology and Immunology Lactate receptor GPR81 drives breast cancer growth and DLL4 Published date November 22, 2023 Abstract " Background: The lactate receptor GPR81 contributes to cancer Here, we investigate the roles of GPR81 in three-dimensional (3D) and in vivo growth of breast cancer Methods: GPR81 was stably knocked down (KD) in MCF-7 human breast cancer cells which were subjected to lactate and 3D growth in breast cancer spheroids.

in Oncology and Immunology Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer their respective di and mono-phosphate nucleoside forms, contributing significantly to immune biology, cancer

< GPCRs in Oncology and Immunology GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer GPR143 is elevated in multiple cancers, and quantitative proteomic and RNA profiling of exosomes in human cancer cell lines showed that the GPR143-ESCRT pathway promotes secretion of exosomes that carry unique findings provide a mechanism for regulating the exosomal proteome and demonstrate its ability to promote cancer , Sun-Young Kong , Taejoon Kwon , Pann-Ghill Suh , Young Chan Chae Tags GPR143 , HRS , MVB , breast cancer

GPCR News < GPCRs in Oncology and Immunology Purinergic GPCR-integrin interactions drive pancreatic cancer P2RY2 presents as the purinergic gene with the strongest association with hypoxia, the highest cancer Moreover, receptor-integrin interactions were required for effective downstream signalling, leading to cancer This work elucidates a novel GPCR-integrin interaction in cancer invasion, highlighting its potential Ariana Samadi , Hemant M Kocher , Sabrina Simoncelli , Peter J McCormick , Richard Philip Grose Tags cancer

GPCRs in Oncology and Immunology The β2-adrenergic receptor associates with CXCR4 multimers in human cancer found that CXCR4 assembles into multimeric complexes larger than dimers in MDA-MB-231 human breast cancer cells and in HCC4006 human lung cancer cells. These results suggest that CXCR4-β2AR heteromers are present in human cancer cells and that GPCR multimerization

GPCRs in Oncology and Immunology Autocrine proteinase-activated receptor signaling in PC3 prostate cancer

Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer and is involved in several cancer phenotypes including tumor growth, survival, and metastasis. The roles of histamine and histamine receptor H1 (HRH1) in cancer pathogenesis remain controversial. Here, we show that HRH1 is widely expressed in various cancer cell lines and cancer tissues and that coexpression of CXCR4 and HRH1 is associated with poor prognosis in breast cancer.

Immunology Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer This abundance is exploited for cancer imaging, but there is interest in pharmacological inhibition of the NPYRs to interrogate their functional relevance in breast cancer. Therefore, these antagonists may aid in the development of novel cancer therapeutics and patient-based Tags Breast cancer , GPCR , Hypoxia , NPY , Neuropeptide .

In addition, the platform was used to develop assays for high-throughput screening for challenging adhesion Sabbagh undertook post-doctoral fellowships at the Ontario Cancer Institute and the University of Toronto projects aimed on drug discovery of small molecules for the treatment of inflammatory disorders and cancer Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC the development of innovative treatments for a range of diseases, including psychiatric disorders and cancer

< GPCR News < GPCRs in Oncology and Immunology Molecular characterization of breast cancer cell pools Abstract "Background: About one-third of patients with estrogen receptor alpha (ERα)-positive breast cancer PR is an important prognostic factor in breast cancer. New evidence has shown that progesterone (P4) has an anti-proliferative effect in ERα-positive breast cancer However, the role of PR in breast cancer is only poorly understood.

< GPCR News < GPCRs in Oncology and Immunology Functional Assessment of Cancer-Linked Mutations in Sensitive Genetic variants in RGS proteins are associated with many diseases, including cancers, although the impact Intolerant and tolerant-control residues that overlap with pathogenic cancer mutations reported in the COSMIC cancer database were selected to define the functional phenotype. , including cancer-linked mutations in regulator of G protein signaling (RGS) proteins.

Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases and cancers is G protein-coupled receptor (GPCR) and plays important roles in various inflammatory diseases and cancers , including chronic obstructive pulmonary disease (COPD), atherosclerosis, asthma, and pancreatic cancer structure-activity relationships and clinical significance of CXCR2 antagonists in inflammatory diseases and cancers Authors Yishi Xie , Wenbin Kuang , Dawei Wang , Kai Yuan , Peng Yang Tags CXCR2 , CXCR2 antagonist , Cancer

Oncology and Immunology Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer GIV/Girdin has emerged as a prototypical non-GPCR activator of G proteins that promotes cancer metastasis blocking noncanonical G-protein signaling in tumor cells and inhibiting proinvasive traits of metastatic cancer Tags G protein , GPCR , cancer , drug discovery .