cancer therapy Published date September 12, 2024 Abstract "G protein-coupled receptors (GPCRs) are vital cell Despite their crucial role in regulating antitumor immunity and tumorigenesis, therapeutic applications the review highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity , cancer cell expansion, and blood vessel development. Donato Inverso, Carlotta Tacconi, Serena Ranucci, Marco De Giovanni Tags Angiogenesis , Cancer , GPCRs , Immunity

and Immunology Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune Loss of Gpr101 on macrophages was also associated with a significant disruption in their cellular metabolism , Maria Gonzalez-Nunez , Ana Chopo-Pizarro , Jesmond Dalli Tags Acute inflammation , GPCR , Innate immunity Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

GPCR News < GPCRs in Oncology and Immunology CB2 stimulation of adipose resident ILC2s orchestrates immune Group 2 innate lymphoid cells (ILC2s) play a critical role in maintaining adipose homeostasis via the resistance Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

< GPCR News < GPCRs in Oncology and Immunology Identification of S1PR4 as an immune modulator for favorable Molecular biology Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Targeting adenosine signaling for immuno-oncology signaling through A2A and A2B G protein-coupled receptors is increasingly recognized as an important immune checkpoint in the generation of anti-tumor immunity. identified the adenosine-producing enzyme CD73 as a new cancer target, and for his translational work in immuno-oncology immunotherapies, and member of the SAB of Domain Therapeutics, a biopharmaceutical company focused on GPCR in immuno-oncology

The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy . Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

G protein-coupled receptors (GPCRs, the largest family of human cell surface receptors) are associated The levels of GPCRRGs were examined in normal and OV cell lines using quantitative reverse-Etranscription GPCRRG expression was correlated with immune infiltration rates. prognostic model elaborates on the roles of GPCRRGs in OV and provides a new tool for prognosis and immune Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled receptor , Immune

CXCR6 deficiency lowers TRM cell numbers in the lungs and depletes ILC3s in the lamina propria, impairing Together, these highlight that the CXCL16-CXCR6 axis is pivotal in host immunity. The unique DRF motif of CXCR6 facilitates leukocyte adhesion by interacting with cell surface-expressed Notably, single-cell RNA sequencing of the lung shows a drop in TRM cells in species with CXCR6 loss, with implications for immunity against viral diseases and vaccines inducing CD8 TRM cells."

SCI-IDS predominantly occurs following injury above the T5 levels and eventually leads to systemic immune and the HPA axis was explored by histology and multitissue transcriptomics, and the neuroendocrine-immune Results: The spleen and thymus gland, which are secondary immune organs, were significantly atrophied rt1-da, rt1-ba, cd74, cxcr3, vcam1, ccl5, bin1, and IL8) were significantly enriched in MHC-mediated immune this study assessed the differential regulation of the gene network associated with neuroendocrine immunity

Stimulation of GAL2 receptor may modulate immune surveillance and inhibits PDAC via cell cycle inhibition Pathways linked to these tumor suppressor proteins may enhance immune surveillance, prevent carcinogenesis , pancreas Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

< GPCR News < GPCRs in Oncology and Immunology CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes Published date March 21, 2023 Abstract "Dendritic cells (DCs) and monocytes capture, transport, and present antigen to cognate T cells in the draining lymph nodes (LNs) in a CCR7 monocytes use CCR5 to follow CCL5-secreting migratory cDCs into the LN, where they regulate DC-mediated immunity Jakubzick Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

News < GPCRs in Oncology and Immunology Purinergic GPCR-integrin interactions drive pancreatic cancer cell druggable extracellular proteins, this axis plays essential roles in fibrosis, inflammation response and immune P2RY2 presents as the purinergic gene with the strongest association with hypoxia, the highest cancer cell-specific receptor-integrin interactions were required for effective downstream signalling, leading to cancer cell Hemant M Kocher , Sabrina Simoncelli , Peter J McCormick , Richard Philip Grose Tags cancer biology , cell

We studied injury-induced immune dysfunction seeking novel means to reverse such predisposition. antimicrobial functions (cytoskeletal reorganization, chemotaxis (CTX), phagocytosis, bacterial killing) in cellular Predicted rescue therapies were assessed in cell systems and mouse injury-dependent pneumonia models. Conclusions: Tissue injury-derived DAMPs suppress antimicrobial immunity via canonical GRK2 activation Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

sink for CCL19 to coordinate collective leukocyte migration Published date September 1, 2023 Abstract "Immune Whereas it is well established that single-cell migration is often guided by gradients of chemokines Upon exposure to the CCR7 ligand CCL19, dendritic cells (DCs) effectively internalize the receptor and patterns to the size and geometry of the environment, and provide a guidance cue for other comigrating cells dual role of CCR7 as a GPCR that both senses and consumes its ligand can thus provide a novel mode of cellular

Immunology Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell remodeling regulation of actin cytoskeleton organization by the kinase effectors of Rho GTPases" and "Immune response B cell antigen receptor (BCR) pathway". A single-cell analysis was used to assess GNAI3 expression in GBM. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

P2Y12R activation can promote platelet aggregation and adhesion to cancer cells, promote tumor angiogenesis , and affect the tumor immune microenvironment (TIME) and tumor drug resistance, which is conducive to microenvironment Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

controlling their steady state trafficking and sometimes their agonist-induced internalisation, as well surface levels of the GPCRs C5aR1 and CXCR4 in neutrophils, and suppresses neutrophil-mediated innate immunity Norbin in the trafficking of endogenous C5aR1 and CXCR4 in primary neutrophils by flow cytometry and cell β-arrestin-dependent mechanism and limits the recycling of internalised C5aR1 and CXCR4 back to the cell β-arrestin Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Novoprotein developed a NovoiSMART technology, utilizing mRNA-based immunization, which can overcome These studies show that mRNA immunization yields higher antibody titers and greater epitope diversity

Timo started working as a postdoctoral researcher at the Vrije Universiteit Brussel in the In Vivo Cellular He currently is focusing on the development of nanobody-based immuno tracers as part of the IMI/EFPIA project entitled "Immune Image".

In this issue of Immunity, Gour et al. demonstrate that the GPCR Mrgpra1 and the neuropeptide NPFF, molecules Bryan G Yipp Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by disrupted immune patients had a lower microbiota richness and bacterial load, with a higher proportion of the genus Cellulosimicrobium of GPR109A was studied in depth and increased expression of this receptor was detected in epithelial cells and cells from lamina propria, including CD68+ macrophages, in IBD patients. macrophages Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

by decreased creatinine clearance and urea excretion and a decreased presence of regulatory T (Treg) cells In this setting, OGR1 KO mice displayed an increased activation of the immune system and a higher production of pro-inflammatory cytokines by T cells and macrophages. kidney stones Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Replication by Regulating Ca2+ Flux Published date May 29, 2023 Abstract "Chemokine production by epithelial cells coronavirus porcine epidemic diarrhea virus (PEDV) infection in African green monkey kidney epithelial cells (Vero) and Lilly Laboratories cell-porcine kidney 1 epithelial cells (LLC-PK1). These findings provide a better understanding of the role of IL-8 in PEDV-induced immune responses, which Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Univariant and multivariant Cox regression analyses, as well as least absolute shrinkage and selection The tumor immune dysfunction and exclusion (TIDE) algorithm was utilized to evaluate immune infiltration treatment Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

., PNAS, 2014) in breast cancer pathogenesis, using mouse models, three-dimensional cell culture and Mike's Research on Cell Polarity and GPCRs in Cancer Mike shared his research on cell polarity and its cancer cells, and suggested a therapeutic index for a drug called JTE-6.7. GPCRs and Cancer Immune Modulation Yamina and Mike had a discussion about their research on GPCRs, specifically They also touched upon the potential of GPCR modulation in stimulating the immune system to fight cancer

postdoctoral work that led to Nick's interest in peptide messengers regulating appetite, metabolism, and the immune Bioscience as Chief Scientific Officer, a contract research organization specializing in molecular and cellular

pathogenesis of Long-COVID is currently under heavy scrutiny and existing data on the role of auto-immune Nina Babel Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

CCRs were significantly induced in spleen of largemouth bass, indicating their important roles in the immune Selection pressure Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call