Class B1 GPCRs are an important subclass of GPCRs that include 15 receptors involved in regulating body Nature Communications, 2024. 15 (1): p. 4390. 7.         

November 2021 "Nov. 15, 2021 LONDON – There’s not yet proof of the pudding, but Omass Therapeutics Ltd

role of GPCRs in obesity pathology for drug development GPCR Events, Meetings, and Webinars March 13 - 15 | Biologics 2024 March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition

Allosteric Modulator Research Collaboration for Substance Use Disorders "Geneva, Switzerland, August 15

We have 15 GPCR papers, three industry news, and two job ads. Logo Contest: Unleash your creativity and submit your design by August 15, 2024.

(May 14 - 19, 2023) PEGS Boston (May 15 - 19, 2023) 8th and final ERNEST Meeting in Crete. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

The Revolutionary Impact of Cryo-EM on GPCR Research GPCR Events, Meetings, and Webinars March 13 - 15 | Biologics 2024 March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition

has completed Phase 1 studies in Japan with JNJ-40411813 (ADX71149) "Geneva, Switzerland, November 15

(May 14 - 19, 2023) PEGS Boston (May 15 - 19, 2023) 8th and final ERNEST Meeting in Crete. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

(May 14 - 19, 2023) NEW PEGS Boston (May 15 - 19, 2023) 8th and final ERNEST Meeting in Crete. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

However, the NN-based methods (AlphaFold and RoseTTAFold) outperformed Modeller in 21 and 15 out of the

the BERKY and the ONE-GO biosensors, designed to facilitate their application in disease models[3, 15 Nat Protoc, 2006. 1(1): p. 337-45. 15.   

However only ~15% of the GPCR superfamily has been successfully drugged, due in part to the intractability Orion used its discovery platform technology to rapidly develop a murinized version of OB-004 that was Figure 7: In vivo efficacy of murinized OB-004 (mOB-004) in the thioglycolate (TG) induced peritonitis murine model.

Webinars February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery NEW March 13 - 15 | Biologics 2024 March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition

3rd Annual Meeting IRN I-GPCRNet November 2 - 4, 2023 | GPCR Retreat- Registration Closed November 15

The highest affinity compounds (15 to 24 nM) were identified from AF2 docking.

Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth of murine

NEW MPGPCR Conference (November 15 -17, 2023) Structure, Mechanism, and Drug Interactions of GPCRs, Ion

FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

altered transcriptional expressions of some neuronal Gα genes, including gpa-5, gpa-10, gpa-11, gpa-15

IRN I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) MPGPCR Conference (November 15

Cardiology, Endocrinology, and Taste Single-cell transcriptomic atlas of enteroendocrine cells along the murine

, 2023 | GPCR Retreat- Registration Closed November 10, 2023 | Sosei Heptares Zoom Webinar November 15

Logo Contest : Let your creativity shine by submitting your design for the Logo Contest before August 15

We have 15 GPCR papers and four industry news. This week's highlight includes congrats to: Drs. 

everyone, Please take a moment to explore our most recent coverage of GPCRs this week, which includes 15

FREE Symposium - IPI Surfacing (June 15, 2023) NEW GPCRs in drug discovery: challenges & solutions (June

MPGPCR Conference (November 15 -17, 2023) Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels