GPR81 KD increased spheroid necrosis, reduced invasion and in vivo tumor growth, and altered expression F Pedersen Tags EPHA7 , Extracellular matrix , HCAR1 , Metabolite GPCR , Notch , PCDH7 , Spheroid , Tumor

Invasive procedures alone are not effective at completely removing such tumors. Within this dataset, we observed the association in the tumor microenvironment between the gene expression

We showed that CD97 (ADGRE5), in particular, drives tumor growth via effects on GBM stem cell self-renewal patient-derived GBM xenografts in the brain of immunodeficient mice resulted in significant reduction of tumor Collectively, these data suggest that ADCs targeting CD97 impair tumor growth in preclinical GBM models As a clinician, he specializes in surgical treatment of brain tumors.

polyadenylation as a targetable driver of pancreatic cancer, and 2) dysregulation of the pancreatic tumor Ricky's group at UPenn to explore the GPCR side of the lab, which led to the discovery of potential tumor had a discussion about their research on GPCRs, specifically focusing on GPR68 and its role in the tumor his team's current focus on alprazolam, an anti-anxiety medication that has unexpected effects in the tumor his experiments and discoveries about GPR161 in mammary epithelial cells, the effect of alprazolam on tumors

< GPCR News < GPCRs in Oncology and Immunology LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced Coexpression of LPA1 with CXCR4 reduced CXCL12-mediated cAMP inhibition, ERK activation, Gαi/o activation In contrast, CXCR4 had no impact on LPA1-mediated signaling.

antibodies for complex targets, with implications for overcoming challenges like drug resistance and tumor

< GPCR News < GPCRs in Oncology and Immunology G Protein-coupled Receptor-mediated Membrane Targeting Here, we show that chemoattractant/GPCR-mediated membrane recruitment of PLCγ2 constitutes GPCR-mediated

in Oncology and Immunology Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated

< GPCR News < GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral immunity Published date April 4, 2024 Abstract "Efficient induction of humoral immune responses depends on orchestrated GRKs) at distinct sites on the receptor C termini, which dictates functional outcomes of β-arrestin-mediated to chemoattractant receptors and plays an important role in the control of B cell migration during humoral review, we summarize the current understanding of chemoattractant receptor signaling in the context of humoral

protein-coupled receptors is increasingly recognized as an important immune checkpoint in the generation of anti-tumor

highly expressed in many cancer cells, including prostate cancer (PCa), and regulate various aspects of tumor

Published date June 26, 2023 Abstract "G protein-coupled receptors (GPCRs) play important roles in tumorigenesis Previous studies have indicated that GPR50 could protect against breast cancer development and decrease tumor

The roles of these non-canonical chemoreceptors in cancer are complex, with some receptors promoting tumorigenesis and others acting as tumor-suppressing factors upon activation, depending on the cancer type.

specifically disrupted their engagement with GIV/Girdin, thereby blocking noncanonical G-protein signaling in tumor

Importantly, 8GL alone or in combination with an mTOR inhibitor remarkably impaired tumor growth and

cytomegalovirus (HCMV) is associated with accelerated progression of glioblastomas, aggressive brain tumors Here, we showed that US28 increased the malignancy of U251 glioblastoma cells by enhancing signaling mediated study uncovers central roles for S1P and CIP2A in feed-forward signaling that contributes to the US28-mediated

role of G protein-coupled receptor kinase 2 (GRK2), a known regulator of Gq-GPCR signaling in HNSCC tumor

Single-cell transcriptome further delineated the tumor microenvironment as immune-inflamed, -deficient Collectively, our study identified a previously unknown GPCR-mediated malignant progression and translated

In human breast tumor tissue, we show via immunofluorescence that NPY5R protein levels and colocalization

We confirmed the elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors Mechanistically, RGS16 restrained JNK/P38-mediated apoptosis in CRC cells through disrupting the recruitment

widely overexpressed in various types of cancer and is involved in several cancer phenotypes including tumor

The combined effects of chidamide and BV were demonstrated in a study of HH-cell xenograft mice; mean tumor

Mechanistically, UCA1 sequesters let-7 miRNAs, effectively neutralizing their tumor-suppressive functions

Zihan Quan , Yuting Zhan , Haihua Wang , Jiadi Luo , Weiyuan Wang , Songqing Fan Tags biomarkers , tumor

prognosis Published date June 18, 2024 Abstract " Background: Ovarian cancer (OV) is a common malignant tumor

Immunology Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated The level of cortisol, which is mediated by the adrenal glands, was markedly elevated, but norepinephrine P2ry12, rt1-bb1, Oprm1, Zfhx2, Gpr83, and Chrm2) were enriched in pathways related to inhibitory Gi-mediated rt1-bb1, rt1-da, rt1-ba, cd74, cxcr3, vcam1, ccl5, bin1, and IL8) were significantly enriched in MHC-mediated Progressive neuroinflammation spreads after injury, and neurotransmission through Gi-mediated G protein-coupled

Richard Vile's lab at Mayo Clinic where she aided the evaluation of tumor-specific oncolytic viruses.

endothelial cell identity and function Monserrat Avila Zozaya Adhesion GPCR BAI1/ADGRB1 can block IGF1R-mediated GPCR Adhesion GPCR BAI1/ADGRB1 can block IGF1R-mediated growth signalling, increase radiosensitivity His research interest lies in understanding the molecular basis for human tumor development and how to s research examines how genetic alterations and hypoxia induce changes in cell biology that promote tumor