Search Results
113 items found for "physical function"
- Plenary Lecture | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Plenary Lecture Identification and Functional has focused on G protein coupled receptors, in particular, the ligand identification, physiological functions the “flute model” and “poly proline region docking theory” etc. to explain the arrestin mediated GPCR functions
- NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
NPFF regulates a variety of physiological functions by binding to a G protein-coupled receptor (GPCR) However, to date, the expression and/or function of NPFF/NPFFR2 in EOC is undetermined. Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- Signaling by Neutrophil G Protein-Coupled Receptors that Regulate the Release of Superoxide Anions
receptors (FPRs) and free fatty acids recognized by free fatty acid receptors (FFARs) regulate neutrophil functions The receptors have signaling and functional similarities, although there are also important differences Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10
A functional analogue of GBP, stress-responsive peptide (SRP), was also identified in the same species Although GBP1 (CG15917) and GBP2 (CG11395) have been identified in Drosophila melanogaster, immunological functions Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment
type 9 (AAV) carrying RGS5 cDNA or small hairpin RNA (shRNA) targeting RGS5 were used to determine the functional Conclusions: These findings suggest that tumor microenvironment shifts the function of RGS5 from anti-inflammation Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- Principles of Pharmacology in Drug Discovery II
Receptor data shows how GPCR control of cellular function goes far beyond simple second messenger production learn: The powerful applications of new cellular assays to determine GPCR ligand behavior in different functional My interests are in receptor theory, pharmacology applied to drug discovery and allosteric protein function
- Principles of Pharmacology in Drug Discovery II
Receptor data shows how GPCR control of cellular function goes far beyond simple second messenger production learn: The powerful applications of new cellular assays to determine GPCR ligand behavior in different functional therapeutically exploit GPCRs (Physiology’s ‘Swiss Army Knife’) wide repertoire of ways to control cell function
- Ep 59 with Dr. Nicola J. Smith
Nicola J Smith is an expert in molecular pharmacology with a track record in exploring GPCR structure-function culture and ex vivo models) and in vivo (measures of physiological and pathological cardiometabolic function
- Ep 16 with Dr. Aaron Sato
earned his Ph.D. at the Massachusetts Institute of Technology, where he studied MHC class II structure-function manufacture DNA at a scale, the team saw an opportunity to tackle the challenge of identifying novel functional
- Ep 93 with Dr. Sri Kosuri
Kosuri Sri is a biologist that has helped build technologies, labs, and companies in synthetic biology, functional protein biochemistry, human genetic variation, gene regulation, chemical biology, synthetic biology, and functional
- Full Agenda for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Adhesion GPCR in Mechanobiology Tobias Langenhan Read More 1:00 PM Plenary Lecture Identification and Functional snacks Read More 11:00 AM Session III Molecular tools and biosensors directed at AGPCR signaling and function Ribalta-Mena · Mariam Melkumyan Read More 3:00 PM Session V Structural mechanisms of AGPCR signaling and function Bayonas · Gabriela Aust Read More 2:50 PM Session IX / Technology capsule: Light on aGPCR signaling and function CELSR1 (ADGRC1) In Breast Cancer Mariam Melkumyan GPR110 modulates anxiety-like behaviors and memory function
- Olfactory Receptors and Tumorigenesis: Implications for Diagnosis and Targeted Therapy
sensory neurons and various non-olfactory tissues, serving significant physiological and pathological functions Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- Posters | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Angiogenesis Inhibitor 3 (BAI3) in WNT-Activated Medulloblastomas Virginea de Araujo Farias Conformational And Functional GPCR ADGRL1 / Latrophilin-1 Sheila Ribalta-Mena GPR110 modulates anxiety-like behaviors and memory function This mouse model will be useful to delineate the collecting duct-specific role of GPR56 for renal function Ligand binding and mechanical force applied on the ECR regulate receptor function. Anxiety and memory function were tested using both male and female mice at 5-6 month of age.
- Ep 33 with Dr. David E. Gloriam
Computational Receptor Biology at the University of Copenhagen where he leads a research cluster for GPCR function He later identified physiological hormones of such under characterized ‘orphan’ receptors and functional
- GPR37 expression as a prognostic marker in gliomas: a bioinformatics-based analysis
Methods: We explored the diagnostic value, clinical relevance, and molecular function of GPR37 in glioma Functional annotation of GPR37 showed enrichment of ether lipid metabolism, fat digestion and absorption Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration
detail the formation of the CXCR4-LPA1 heteromer and characterized the unique molecular features and function To elucidate the distinctive molecular characteristics and functional implications of the CXCR4-LPA1 Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity
February 2, 2024 Abstract " Background: Interferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function consequence of natural posttranslational modifications, human CXCL10 exhibits a high degree of structural and functional Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer
The Rottapel lab has shown that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell function and scavenger receptor activation."
- Ep 54 with Dr. JoAnn Trejo
Trejo’s research has focused on PAR1, which has important functions in hemostasis, thrombosis, inflammation novel aspects of GPCR biology, acquired critical expertise, and rigorous approaches to examine PAR1 function
- GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis
Through gain- and loss-of-function studies in mice, we show that GPR143 promotes metastasis by secreting Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis
nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis Published date June 26, 2023 Abstract "The functional Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- Principles of Pharmacology in Drug Discovery I
Lecture 2: Drug Affinity: Measurement of Antagonism (Binding and Function) / Classifying Antagonists. My interests are in receptor theory, pharmacology applied to drug discovery and allosteric protein function
- Ep 121 with Yao Lu (Jackie)
Lu (Jackie) "Jackie is a Ph.D. student, at Monash University, Australia, investigating the role of functional
- Trademark Policy | Dr. GPCR Ecosystem
GPCR button to enable content and functionality. When a Publisher directs users to a Dr. For the Share button, the content or functionality that is enabled for the user must also be accessible domain names - as app icons or featured in an app - as the most prominent elements on your website - on physical
- Clinical, pathophysiologic, genetic and therapeutic progress in Primary Bilateral Macronodular Adrenal Hyperplasia
Functional studies demonstrated that inactivation of KDM1A leads to GIP-receptor (GIPR) overexpression Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
September 30, 2023 Abstract "Background: Spinal cord injury (SCI), which causes loss of sensory and motor function ) in the T3-SCI group were enriched in the GO term immunoregulation, indicating that splenic immune function Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function
- Ep 12 with Dr. Antonella Di Pizio
learn more about chemosensory GPCRs and how computational pharmacology can help better understand their function
- Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design
The potent inhibitory function of Pc(4-4) is demonstrated via inhibition of ovarian cancer peritoneal Endocrinology, and Taste GPCRs in Oncology and Immunology Structural and molecular insights into GPCR function