< GPCR News < GPCRs in Oncology and Immunology Unveiling G-protein coupled receptors as potential targets of ovarian cancer, a future personalised approach could include the identification of unique GPCRs expressed Here we report on the systematic analysis of public ribonucleic acid-sequencing (RNA-seq) gene expression cancer cells derived from ascites and ovarian cancer cell lines were used to confirm frequent gene expression However, the expression levels showed high variability within our selection of samples, therefore, supporting

< GPCR News < GPCRs in Oncology and Immunology Combinatorial depletions of G-protein coupled receptor cells identify pleiotropic and cell type-specific functions Published date November 1, 2022 Abstract G-protein They can be recruited to agonist-activated G-protein coupled receptors (GPCRs) and phosphorylate their Immune cells commonly express two to four members of the GRK family (GRK2, GRK3, GRK5, GRK6) simultaneously Authors Katharina M Glaser, Teresa K Tarrant, Tim Lämmermann Tags B cells; G-protein coupled receptors

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression Published date July 31, 2024 Abstract "G protein-coupled receptors (GPCRs) are Additionally, we focus on the roles of GPCRs in regulating immune checkpoint proteins involved in immune

< GPCR News < GPCRs in Oncology and Immunology Intermediate-state-trapped mutants pinpoint G protein-coupled the roles of intermediate states in signaling is pivotal to unraveling the activation processes of G protein-coupled transmembrane helix VI (TM6) and Helix8 that regulates cytoplasmic cavity opening as a "gatekeeper" for G protein Intermediate-state-trapped mutants will also provide useful information in relation to receptor-G protein

< GPCR News < GPCRs in Oncology and Immunology Interplay between G protein-coupled receptors and nanotechnology Published date July 28, 2023 Abstract "G protein-coupled receptors (GPCRs), as the largest family of , Rujing Wang , Mengnan Zhao , Canquan Mao , Sanjun Shi Tags Drug delivery , Endosomal delivery , G protein-coupled

< GPCR News < GPCRs in Oncology and Immunology DANGER Signals Activate G-Protein Receptor Kinases Suppressing Mitochondrial (mt) formyl peptides (FP) activate G-protein coupled receptors (GPCR) like FPR1. mtDNA Methods: We studied human and mouse PMN signaling elicited by mtDAMPs (GPCR surface expression; protein

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptors related to autoimmunity in In particular, the association of the disease with several types of anti-G protein-coupled receptor ( Authors Yoko Sunami, Keizo Sugaya, Kazushi Takahashi Tags G protein-coupled receptors , Autoimmunity

< GPCR News < GPCRs in Oncology and Immunology G Protein-coupled Receptor-mediated Membrane Targeting Neutrophil Chemotaxis Published date April 11, 2023 Abstract " The current dogma is that chemoattractants G protein-coupled Tags G protein-coupled receptor (GPCR) , calcium-promoted Ras inactivator (CAPRI) , chemotaxis , neutrophils

GPCR News < GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors Published date December 1, 2022 Abstract G Protein-coupled receptors (GPCRs) are the most While the location of the mutations across the protein domains did not differ significantly in the two

Oncology and Immunology Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled We further identified that the over-expression of miR-19a could regulate the signaling between GRK6, Wei , Tianyi Zhang , Yu Zhu , Jia Feng , Feng Qin , Yanwen Yang , Chuanyuan Wei , Jianying Gu Tags G protein-coupled

< GPCR News < GPCRs in Oncology and Immunology Exploiting frequent and specific expression of PRL3 in However, its physiological expression in pediatric embryonal and mesenchymal tumors and its association We sought to profile the expression of PRL3 in pediatric tumors in relation to survival outcomes, expression of angiogenesis markers, and G-protein-coupled receptor (GPCR)-mitogen-activated protein kinase (MAPK PRL3 was expressed in 75% of relapsed tumors and associated with shorter median event-free survival.

Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design Published date While the involvement of G-protein-coupled receptors (GPCRs) in cancer is growing, GPCR-based therapies FTs, the origin of ovarian cancer, are known to express genes of serous tubal intraepithelial carcinoma PAR2 expression in FTs may serve as an early prediction sensor for ovarian cancer. These motifs associate with PH-signal proteins via launching a discrete signaling network in cancer.

signaling (RGS) are a family of approximately 30 proteins that bind to and deactivate the alpha subunits of G-proteins (Gα) by accelerating their GTP hydrolysis rates, which terminates G-protein coupled receptor Thus, RGS proteins are essential in regulating GPCR signaling, and most members are implicated as critical Regulator of G-protein signaling 2 (RGS2), a member of the R4 family of RGS proteins, is overexpressed All 10 compounds inhibited the growth of several RGS2 expressing cancers in cell culture assays.

Increased VIPR2 mRNA expression and/or VIPR2 gene copy number has been documented in several cancers phosphorylation of vasodilator-stimulated phosphoprotein (Ser157) and cAMP response element binding protein Moreover, an inhibitor of mitogen-activated protein kinase kinase, U0126, attenuated tumor proliferation in exogenous VIPR2-expressing MCF-7 and MDA-MB-231 cells at the same level as observed in EGFP-expressing expression of VIPR2 may lead to an exacerbation of breast carcinoma. ” Authors Satoshi Asano , Ami Ono

hunting Published date June 14, 2024 Abstract "Initiation of development requires differential gene expression the nematode-trapping fungus, Arthrobotrys flagrans, that both are achieved through a dual-function G-protein-coupled Gene-expression analyses revealed that ascarosides activate the fungal GPCR, GprC, at the plasma membrane and together with the G-protein alpha subunit GasA, reprograms the cell. An SRBC64/66-GprC chimaeric protein was functional in A. flagrans, and C. elegans SRBC64/66 and DAF38

This metabolite binds to and regulates the function of diverse proteins intracellularly to influence metabolism, oxidative response, epigenetic modification, and gene expression and to signal extracellularly through binding the G protein-coupled receptor (GPCR). Administration of ITA protects against inflammatory diseases and blockade of ITA production enhances In this article, we review ITA metabolism and its regulation, discuss its target proteins and mechanisms

, they shared their views on pursuing one's passions and not being afraid of the unknown, and Demet expressed Yamina expressed her appreciation for Demet's work and asked about the development of the GPCR field They also addressed the naming conventions of proteins in the field, with Yamina expressing concern about Lastly, they shared their preferences for GPCRs, with Demet expressing a particular fondness for certain Yamina expressed her love for the GPCR field and asked for advice for junior scientists interested in

alizarin red S staining and detecting the changes of ALP and runt-related transcription factor 2 (RUNX2) proteins receptor (GPCR)-kinase interacting protein 2 (GIT2). Results: CircFKBP5 expression was decreased in hDPSCs and, functionally, reexpression of circFKBP5 attenuated LPS induced miR-708-5p expression in hDPSCs, and knockdown of miR-708-5p protected against LPS-evoked Besides, GIT2 expression was decreased in hDPSCs after LPS treatment.

psychoactive drugs intersect with genetic risk factors for mental illnesses such as schizophrenia, depression These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular The Beaulieu group is presently investigating how cell surface express proteins can act as allosteric These investigations have led to the identification of an RNA binding protein (FXR1P) involved in the regulation of protein synthesis as a potential downstream effector of the action of mood stabilizers

by the tumor microenvironment Published date November 20, 2023 Abstract " Background: Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor (GPCR) signaling, is highly expressed in arterial VSMCs and pericytes, which is involved in VSMC phenotypic heterogeneity and vascular RGS5 expression in the triple-negative (TNBCs) and non-triple-negative breast cancers (Non-TNBCs) was RGS5 expression was increased in the triple-negative breast cancer (TNBC) tissues and in the tumor blood

cancer cells Published date April 2, 2024 Abstract "While the existence and functional role of class C G-protein-coupled PIE-FCCS can resolve membrane protein density, diffusion, and multimerization state in live cells at physiological expression levels. , Chulo Park , Piotr Zalicki , Jae-Yeon Jeong , Won-Ki Huh , Niña G Caculitan , Adam W Smith Tags G-protein-coupled receptors , fluorescence spectroscopy , membrane protein interactions Source Contribute to the GPCR

psychoactive drugs intersect with genetic risk factors for mental illnesses such as schizophrenia, depression These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular The Beaulieu group is presently investigating how cell surface express proteins can act as allosteric These investigations have led to the identification of an RNA binding protein (FXR1P) involved in the regulation of protein synthesis as a potential downstream effector of the action of mood stabilizers

< GPCR News < GPCRs in Oncology and Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency nephropathy in female mice Published date July 11, 2023 Abstract "OGR1 (Gpr68) and GPR4 (Gpr4) are proton-activated G protein-coupled receptors that are stimulated upon increased extracellular acidity. </p> Taken together, in the acute setting of oxalate-induced nephropathy, the lack of the proton-activated Krudewig , Giovanni Pellegrini , Nicole Joller , Carsten A Wagner , Pedro Henrique Imenez Silva Tags G-protein-coupled

deposition of extracellular matrix proteins, particularly collagen, caused by myofibroblasts in response Although G protein-coupled receptors (GPCRs) are among the targets of current antifibrotic drugs, no In gene expression analysis of mouse lungs with induced fibrosis, eight GPCRs were identified, showing a >2-fold increase in mRNA expression after fibrosis induction. Furthermore, fibroblasts abundantly expressed Gpr176 compared to alveolar epithelial cells, endothelial

and boosts HIV-1 R5 replication Published date May 21, 2024 Abstract " Objective: CCR5, a G protein-coupled Methods: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR. Cell lines expressing EBI2 were established by transduction with HIV vectors. The amount of HIV reverse transcripts was similar in cells expressing or not EBI2. Conclusions: EBI2 expression in CD4+CCR5+ cells boosts HIV-1 R5 productive infection.

News about the GPCR field Sign Up Latest Classified GPCR News Adhesion GPCRs September 25, 2024 The G Protein-Coupled Checkpoint for NK Cell Migration Read More September 12, 2024 Loss of cardiomyocyte-specific Adhesion G Protein G1 (ADGRG1/GPR56) promotes pressure overload-induced heart failure Read More September 5, 2024 The G protein-coupled 2024 Fusarium graminearum Ste2 and Ste3 Receptors Undergo Peroxidase-Induced Heterodimerization when Expressed Read More October 24, 2024 The beta 2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins

< GPCR News < GPCRs in Oncology and Immunology Systems modeling of oncogenic G-protein and GPCR signaling In the present study, we first develop a mechanistic mathematical model of a G-protein coupled receptor

< GPCR News < GPCRs in Oncology and Immunology Stimulation of ectopically expressed muscarinic receptors Here, we demonstrate that stimulating G-protein-coupled muscarinic receptors (M1 and synthetic hM3Dq) agonist, unless they were preactivated by TCR and CD28 stimulation which increased hM3Dq and PLCβ1 expression Clozapine treatment induced high IFN-γ, CD69, and CD25 expression, but surprisingly did not induce substantial Importantly, costimulation of both muscarinic receptors plus the TCR even led to reduced IL-2 expression