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43 items found for "therapy"
- Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking
gnemon (GG) for the development of of pharmaceuticals targeting GPCRs within the context of cancer therapy presents a novel approach for comprehending the therapeutic mechanisms of GG-derived active compounds and thereby
- Interrogating Multiscale Receptors Functions in Space
the Beaulieu Lab has demonstrated that mood stabilizer drugs (e.g. lithium) used for bipolar disorder therapy
- Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone
There are no effective therapies for FD.
- The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells
C-X-C motif chemokine receptor 4 (CXCR4) is a class A GPCR that is a promising target of anticancer therapy
- Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia
PLK1 inhibition with ONV in combination with DAC could be a potential therapy in R/R AML patients, particularly
- Classified News | Dr. GPCR Ecosystem
Outcomes in Patients With Multiple Myeloma and Lymphoma Undergoing Chimeric Antigen Receptor T-Cell Therapy Bispecific antibodies targeting BCMA or GPRC5D are highly effective in relapsed myeloma after CAR T-cell therapy
- DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma
Predicted rescue therapies were assessed in cell systems and mouse injury-dependent pneumonia models.
- Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia
Aim of the study: We hypothesized that Jinqiancao granules could be a potential therapy for prostatitis
- Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer
In the past, studies predicting therapeutic drug targets for cancer therapy focused on the assumption
- Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating Ca2+ Flux
Tags calcium signaling , infection , interleukin-8 , porcine epidemic diarrhea virus , therapy .
- Ep 144 with Dr Aurélien Rizk
discussion concluded with the idea that ligand residence time could be an important factor in effective therapy They also shared their preference for small molecule therapies over protein therapeutics.
- Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure
cardio-pathogenic role of GPCR autoantibodies and suggest that further investigations are required before specific therapies
- Ep 107 with Dr. Roger Sunahara
Our goal is to develop safer beta2AR-selective ligands for the treatment of asthma and acute rescue therapy
- Student Flash Presentations | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
GPR97/ADGRG3 In Neutrophil Biology Tyler Bernadyn Next Generation MBD2 inhibitors for Brain Cancer Therapy Tyler Bernadyn on the web LinkedIn Next Generation MBD2 inhibitors for Brain Cancer Therapy Jesse Stillwell His project is drug discovery focused, with particular interest in use of a novel epigenetic therapy
- GPCR Retreat 2023 - Part I
working alongside the very talented team at Orion who translate important GPCR research into novel therapies
