generating highly refined model structures of C5aR2, respectively in free (inactive), complexed to C-terminal

the function of G protein-coupled receptors (GPCRs). βarrs typically interact with phosphorylated C-terminal

Erythrocytes are terminally differentiated anuclear cells with no transcription and limited translation

localization could contribute to the mechanism of inhibition of αqQ209L by YM, we developed and examined N-terminal

desensitized the GIRK channel current induced by D2 receptor activation that rapidly recovers following termination

Furthermore, after phosphorylating the C-terminal tail and intracellular loop 3 (ICL3) of NF-α1/CPE-5

While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point

3.3 currents GPCR Binders, Drugs, and more LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal ERNEST GPCR early career investigator (ECI) Zoominar Survey 2nd ERNEST Training School – February 20th

cellular signaling network is the crosstalk between G protein-coupled receptors (GPCRs) and receptor tyrosine

value Ciliary length variations impact cilia-mediated signaling and biological responses The receptor tyrosine

Structure-Activity Relationships of Human Urotensin II Peptide Analogues: A Proposed Key Role of the N-Terminal

Differential Responses of the GLP-1 and GLP-2 Receptors to N-Terminal Modification of a Dual Agonist. Surfacing (June 15, 2023) NEW GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023) Training

This dimerization allows the N-terminal activation domain of the receptor to repeatedly engage and disengage

alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress Two C-terminal

GABABR silencing of nerve terminals. FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion

., 2003). β-arrestins, traditionally seen as terminators of G-protein signaling, are now recognised as

GPCRs in Neuroscience Phytocannabinoids in neuromodulation: from omics to epigenetics The receptor tyrosine

microvillous and ciliary phototransductions across M1- through M6-IpRGCs Synaptic plasticity via receptor tyrosine

cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4 Chemokine N-terminal-derived

GPCR Activation and Signaling Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. 2nd ERNEST Training

complex assemblies with β-arrestin serving distinct functions Phosphorylation motif dictates GPCR C-terminal

when the RGS proteins play a key role in the deactivation of the alpha subunit contributing to the termination

For my postdoctoral training, I joined one of the labs that participated in Latrophilins’ discovery, The Teotihuacan Pyramids: although it is very touristy, it is just a hop away from Mexico City and finds

impact ligand binding, receptor activation, G protein interactions, signaling dynamics, and signal termination

activation mechanism of the class C GPCR dimer mGlu5 Altered O-glycosylation of β1-adrenergic receptor N-terminal

GPCRs in Oncology and Immunology LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine SLAS2023 International Conference and Exhibition (February 25 - March 1, 2023). 2nd ERNEST Training School

GPCR-mediated signal transduction, where signaling of most GPCRs via the G-protein-dependent pathway is terminated