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578 items found for "GPCR heteromer"
- Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor
Nanobody binding stabilizes G-protein-coupled receptors (GPCR) in a fully active state and modulates Altogether, our results provide insights into the effect of intracellular binding partners on the GPCR
- Targeted Activation of G-Protein Coupled Receptor-Mediated Ca 2+ Signaling Drives Enhanced Cartilage
This study demonstrated Gαq-G-protein coupled receptor (GPCR)-mediated [Ca2+]i signaling involvement cartilage-like matrix production, and it established hM3Dq as a powerful tool for elucidating the role of GPCR-mediated
- Chronic itch: emerging treatments following new research concepts
However, many new targets, such as Mas-related GPCRs and unexpected new pathways need to be also explored
- Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa
These disorders are mainly related to the abnormalities in the rod G protein-coupled receptor (GPCR),
- Prostaglandin signaling in ciliogenesis and development
Many G-protein-coupled receptors (GPCRs) including EP4 are localized in cilia for modulating cAMP signaling
- Harnessing Deep Mutational Scanning for Enhanced Drug Discovery
residues spans from the extracellular surface to the transmembrane area, linking with canonical class A GPCR activation motifs to initiate proton-sensing GPCRs.
- Applications of Cryo-EM in small molecule and biologics drug design
cryo-EM has enabled insights into important drug target families such as G protein-coupled receptors (GPCRs
- Engineered synaptic tools reveal localized cAMP signaling in synapse assembly
Given that postsynaptic latrophilin adhesion-GPCRs drive synapse formation and produce cAMP, we suggest
- Disentangling bias between G q, GRK2, and arrestin3 recruitment to the M 3 muscarinic acetylcholine
G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular
- On-cell nuclear magnetic resonance spectroscopy to probe cell surface interactions
characterize ligand interactions with cell surface membrane proteins such as G-protein coupled receptors (GPCRs
- Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors
"The effects of the neurohormone melatonin are mediated by the activation of the GPCRs MT1 and MT2 in
- Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas ...
and review Odorant receptors (ORs) account for about 60% of all human G protein-coupled receptors (GPCRs
- Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion ...
their functional activities are achieved by binding to the cell surface G protein-coupled receptors (GPCRs
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
is a key protein that mediates desensitization and internalization of G protein-coupled receptors (GPCRs
- Synaptic integration of subquantal neurotransmission by co-localized G protein coupled receptors in
Colocalization of different actions of GPCRs provide synaptic integration within presynaptic terminals
- HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G 1/S cycle
dependent kinase inhibitor 1B; CQ: chloroquine; E2F1: E2F transcription factor 1; FBS: fetal bovine serum; GPCRs
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial ...
Exendin-4, and possibly through G protein-coupled receptors (GPCRs), increases levels of cAMP and upregulates
- New role of β-arrestins in MOR signaling
Opioid receptors belong to class A of G protein-coupled receptors or GPCRs and signaled mainly through
