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applied with the goal of enabling the discovery of novel therapeutic antibody drug candidates. " Read more

Drug Candidates and Leads Against 10 Oncology Targets – Radionetics and Crinetics to Collaborate on Multiple Read more at the source #DrGPCR #GPCR #IndustryNews

company unlocking the therapeutic potential of G Protein-Coupled Receptors (GPCRs) with a novel drug modality , proven discovery platform and best-in-class molecules, today announced the successful completion of The CCL2/CCR2 pathway plays an important role in oncology, inflammatory, metabolic, and neurological Read more at the source #DrGPCR #GPCR #IndustryNews

While vaccine-makers race to test their shots against the variant, the monoclonal antibody sotrovimab Sotrovimab is the first monoclonal antibody showing preclinical efficacy against all COVID-19 variants , including the delta and omicron mutations, Vir CEO George Scangos said on a Dec. 7 call with analysts Read more at the source #DrGPCR #GPCR #IndustryNews

Read more at the source #DrGPCR #GPCR #IndustryNews

Sharing how she became a scientist, educator, mentor, and the powerhouse we know today.

structure-based technology has passed a key test, in enabling the discovery of orally available small molecules aimed at intractable and poorly drugged membrane and complex-bound protein targets. Read more at the source #DrGPCR #GPCR #IndustryNews

This $60,000 grant from Diabetes Research WA will assist the Perkins' Molecular Endocrinology and Pharmacology Read more at the source #DrGPCR #GPCR #IndustryNews

proud and grateful to receive honorary doctorate yesterday from Karolinska Institute and celebrate with my Read more at the source #DrGPCR #GPCR #IndustryNews

Therapeutics (SIX: ADXN and Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based ADX71149 is a selective metabotropic glutamate type 2 (mGlu2) receptor positive allosteric modulator to be included in a potential global development of ADX71149 for the treatment of epilepsy. " Read more

2021 Positive Recommendation for Use of TAVNEOS™ (avacopan) in ANCA Vasculitis Adopted by European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) "SAN CARLOS, Calif., Nov. 12, 2021 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc., (Nasdaq: CCXI), today announced that the European Medicines polyangiitis (MPA)." Read more at the source #DrGPCR #GPCR #IndustryNews

Nasdaq: TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines Read more at the source #DrGPCR #GPCR #IndustryNews

November 2021 "Target class-specific libraries mean you need to screen less to identify high-quality As a result, most approved library-derived antibodies originate from just three libraries. To target hard-to-drug targets like G protein-coupled receptors (GPCRs), more libraries, including better and more targeted libraries, are needed." Read more at the source #DrGPCR #GPCR #IndustryNews

November 2021 "Chronic use of most opioids causes tolerance; the new compounds avoid this and other unwanted at Scripps Research in Florida have created a collection of new pain-relieving compounds that, like morphine and other drugs, provide relief via activation of opioid receptors, but without inducing many dangerous Read more at the source #DrGPCR #GPCR #IndustryNews

November 2021 Read more at the source #DrGPCR #GPCR #IndustryNews

The vision is to develop novel muscarinic receptor agonists for schizophrenia and other neuropsychiatric Neurocrine Biosciences anticipates initiating a Phase 2 study with the selective M4 agonist HTL-0016878 in schizophrenia in 2022 and Phase 1 studies for a dual M1/M4 and selective M1 agonist in 2023." Read more at the source #DrGPCR #GPCR #IndustryNews

unknown, and there is no ideal drug for the specific treatment of pSS. β-arrestin2 is a key protein that mediates receptors (GPCRs) and it participates in inflammatory and immune responses that have been found to mediate In this study, we established an experimental Sjögren's syndrome (ESS) mouse model to elucidate the molecular mechanisms of β-arrestin2 in pSS. increased saliva flow, alleviated salivary gland indices, and improved tissue integrity in the ESS model

Come attend this month's virtual café talk to see the awesome work of Dr. Stuart Maudsley on how an aging physiological context affects #GPCR signaling #drgpcr.

Don’t miss out on episode 50 of the Dr. GPCR podcast! Give it a listen to hear from Dr. Thomas P. Sakmar on how the molecular studies of rhodopsin paved the way to understanding #GPCRs Be sure to subscribe