Angiotensin 1-7 (Ang-1-7), an endogenous peptide, acts at the G protein coupled MAS1 receptors (MASR)

neural cell populations to the regulation of metabolic processes in adipose tissue, liver, pancreas, adrenal

The medium chain fatty acid receptor GPR84 as well as formyl peptide receptor 2 (FPR2), receptors expressed

a panel discussion at the LSX World Congress Novel living yeast-based dual biosensor for detecting peptide (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

Gαi-derived peptide binds the µ-opioid receptor. (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

protein recruitment assay [6], mini-G recruitment assay [7], GRK and β-arrestin recruitment assays [8] Zhao, P., et al., Activation of the GLP-1 receptor by a non-peptidic agonist.  J Biol Chem, 2018. 293(19): p. 7466-7473. 8.      Biochemical Pharmacology, 2024. 222: p. 116119. 9.      Nat Chem Biol, 2020. 16(8): p. 841-849. 10.   

aGPCR activation is the removal of the inhibitory GAIN domain and the dipping of the cleaved stalk peptide

receptors in phosphorylation of Smad2L and protein expression of PAI-1 induced by endothelin-1 (ET-1) in bovine

October 2022 "Endogenous parathyroid hormone (PTH) and PTH-related peptide (PTHrP) bind to the parathyroid

Here, we report that neurons expressing calcitonin gene-related peptide (CGRP) in the parvocellular subparafascicular

September 2022 "Endogenous parathyroid hormone (PTH) and PTH-related peptide (PTHrP) bind to the parathyroid

out to investigate the physiological importance of autocatalytic cleavage upstream of the agonistic peptide

primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade Allatotropin (AT) related peptides PAC1 receptor activation across species with an engineered sensor A Multi-Angle Approach to Predict Peptide-GPCR

fide agonist of PAR2 that induces unique cellular signaling, distinct from trypsin and PAR2-activating peptide

GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. autophagy activation and inhibition of the PKA-Hippo signaling pathway Blockade of vasoactive intestinal peptide

April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join our Founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. in Cardiology, Endocrinology, and Taste G protein-coupled receptors driven intestinal glucagon-like peptide

receptors (GPCRs) are notoriously difficult to target by small molecules because their large orthosteric peptide-binding

human induced pluripotent stem cell-derived nociceptive-like neurons Characterization of myoinhibitory peptide Alared: Solvatochromic and Fluorogenic Red Amino Acid for Ratiometric Live-cell Imaging of Bioactive Peptides

highly refined model structures of C5aR2, respectively in free (inactive), complexed to C-terminal peptide

mice were healthy over at least 10 generations and showed functional responses to injected PTH analog peptides

Valorization of leftover green tea residues through conversion to bioactive peptides using probiotics-aided (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

To this end we used three different antibodies, all raised against a peptide comprising the C-terminal

MRGPRD and concluded that the observed basal activity of MRGPRD is dependent on the presence of fetal bovine

April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. GPCRs: the Gα-binding-and-activating (GBA) motif Mechanisms of biased agonism by Gαi/o-biased stapled peptide

The endogenous peptide ligand endomorphin-1 (EM-1) underwent almost no significant conformational changes

Gαi containing G proteins and lacks effect on signaling mediated by human neutrophil expressed formyl peptide - 4, 2024 | 19th Annual Drug Discovery Chemistry April 5 - 10, 2024 | AACR Annual Meeting NEW April 22

that complement components react with the fungal surface, leading to opsonization and release of small peptide

Mark your calendars for these important events: September 22: Save the date for the Dr. Protein-Coupled Receptor Landscape Tampering in Lung Fibroblasts GPCRs in Neuroscience System-wide mapping of peptide-GPCR